Báo cáo y học: "Annotations for all by all - the BioSapiens network" pot

... of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark; Esko Ukkonen, Helsinki Institute for Information Technology, Helsinki Univer- sity of Technology and University of ... France. AAcckknnoowwlleeddggeemmeennttss The BioSapiens project is funded by the European Commission within its FP6 Programme, under the thematic area ‘Life sciences, genomics and biotec...

Ngày tải lên: 14/08/2014, 21:20

... appen- dix disorders for further study) [8], and the SAPAS may have greater salience for some specific areas of personal- ity pathology The aim of the present study was to examine the con- vergent ... explained the rationale of the study. Subjects gave consent to participate in the study no earlier than 24 hours after being informed of the pur- pose of the study by th...

Ngày tải lên: 11/08/2014, 16:22

... was strongly dependent on the dose of cortico steroids (P=0.02) - the lower the better - and the dura tion of treatment (P = 0.01) - the longer the better.  en, subgroup analysis based ... a strong heterogeneity across the studies (I 2  = 53% by random-eff ects model), which was mainly explained by diff erences in treatment strategies. Indeed, the met...

Ngày tải lên: 13/08/2014, 21:21

... effects: there was an increased risk for anti-CCP-positive RA in heavy smokers with homozygote SE alleles [67]. In the study of the Leiden Early Arthritis Clinic, the HLA-DRB1*0401, HLA-DRB1*0404, ... components rather than the TNF antagonism alone, evoked by nicotine, may therefore be the main susceptibility factors of disease development. To support this hypothesis, in both ty...

Ngày tải lên: 09/08/2014, 14:22

... revitalized in the US by the fact that the National Science Foundation (NSF) has funded creation of EST libraries for gene discovery and the physical mapping of these ESTs using aneuploid and dele- tion ... Approximately 4,485 ESTs that had been physically mapped into bins along wheat chro- mosomes were compared using the NCBI BLASTN algo- rithm [11] to the first draft of the...

Ngày tải lên: 09/08/2014, 20:20

... parsimonious tree-grow method for haplotype inference (nPTG), identifying differentially expressed pathways via a mixed integer linear programming model (nMILPs), protein-RNA binding-site prediction ... Understanding the interaction between clinical informatics and bioinformatics is the first and critical step to discover and develop the new diagnostics and therapies for disease...

Ngày tải lên: 10/08/2014, 09:22

... A - (E )-3 -( 2-( thiophene-2-yl )-2 , 3- dihydrobenzo[b][1,4]thiazepin-4-yl)phenol (Figure 1) - was built using SYBYL ® software (version 7.3, TRIPOS, St. Louis, MO) [28]. Subsequently, the overall ... significantly. These dynamics have already been inves- tigated extensively by MD simulations, suggesting that the high flexibility of the cleft is necessary for en...

Ngày tải lên: 13/08/2014, 16:20

... with increasing fre- quency in the literature - a search of PubMed on 3 January 2005 produced 11 hits for the new year, more than for all the years before 1998, suggesting that the total of 316 ... systems biology over the next two years, investing £6 million in each. It was in the hope of answering them that a one-day meeting exploring the nature of systems biology an...

Ngày tải lên: 14/08/2014, 14:21

... mechanism. There is a sex-determining locus with many alleles; heterozygous zygotes develop as females, hemizygous or homozygous zygotes develop as males [7]. This hypothesis was confirmed for honey bees ... honey bees by Woyke [8] and the complementary sex determiner (csd) gene was cloned by Beye and colleagues in 2003 [9]. The product of csd is an RNA-binding protein and it may, l...

Ngày tải lên: 14/08/2014, 17:22

... (1 0-1 7)* ( 6-1 1) Y Hugin pyrokinins (1) HUG-PK (8) Y IFamide IFamides (1) IFamide (12) Y Myoinhibiting peptide (MIP) MIPs (5) MIP-1 (9) Y MIP-2 (9) Y MIP-3 (13) Y MIP-4 (11) Y MIP-5 (10) Y Myosuppressin ... the efficacy of DTKs on DTKR - one of the two DTK receptors known - in HEK-293 cells [69]: DTK-1 > DTK-3 = DTK-6 > DTK-4 > DTK-5 > DTK-2. Fo...

Ngày tải lên: 14/08/2014, 20:22