Báo cáo y học: "Universal features in the genome-level evolution of protein domains" pps
Báo cáo y học: "Modular organization in the reductive evolution of protein-protein interaction networks" pps
... network indicate that the roles of proteins within the interaction network are important in the reductive proc-ess. Accordingly, the importance of the roles of the proteinsmust be taken into consideration ... create a highly preservedbackbone of interactions. This emphasizes the crucial impor-tance of connector hubs in maintaining the integrity of the protein network, in contrast to the findings from ... Therefore, rather than frag-menting the network, the removal of nodes and links in the Buchnera network maintains the global topology of the net-work, preserving the main interaction backbone. The prefer-View...
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Báo cáo y học: "Universal features in the genome-level evolution of protein domains" pps
... although the number of domains is increasingly invariant with n, the number of proteins is linear in n. Hence, the number of differ-ent domain combinations in one protein expands, indicatingthat ... domains, enable the construction of increasinglycomplex sets of proteins [9]. In other words, domains are par-ticularly flexible evolutionary building blocks. In particular, the sequences of two duplicate ... scale of description is provided by protein domains [1]. Domains are the basic modular topologies of folded proteins [2]. They con-stitute independent thermodynamically stable structures. The physico-chemical...
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Báo cáo y học: "Structural features in the Rous sarcoma virus RNA stability element are necessary for sensing the correct termination codon" potx
... stopcodonThedatafromtheotherviralUTRssuggestthattheremay be enhancing elements either flanking the primaryfunctional region of the RSE or 5′ of the gag terminationcodon. We hypothesize that the minimal ... functionindependently of the nucleotide sequence of the termi-nation codon and the first nucleo tide following the te r-mination codon. Furthermore, the 3′UTRs of the otherRSV open reading fram es of the ... Secondly, the 3′UTRs of the other viral ter-mination codons may not function by the same mechan-ism as the RSE.TheRSEmaybemorerobustinourassaythantheother viral 3′ UTRs because Gag is the predominantviral...
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Báo cáo y học: "Physical anhedonia in the acute phase of schizophrenia" doc
... patients using the RPAS and the AIMS, the second using the PANSS and the EPSE and the third using the BARS. Information from the patient's his-tory, concerning social-demographic and clinical ... consecutively admitted,with an acute episode of their illness, at the Eginition Hos-pital, Department of Psychiatry, University of Athens, dur-ing a one-year period were studied. Written informedconsent ... Ribot TH: The psychology of emotions London: Scott; 1897. 2. Bleuler E: Originally Published, 1911. In Dementia praecox or the group of schizophrenias Edited by: Tranl, Zinkin J. New York: Interna-tional...
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Báo cáo y học: "Folk medicine in the northern coast of Colombia: an overview" pptx
... corresponding data onmorbidity given by the Office of Health of the depart-ment of Bolívar for the years 2006-2008 [25,26]. The parts of the plant most used for m edicinal pur-poses were, in decreasing ... cimarrones) in the northern coast of Colombia, b eginning in the fif-teenth century. Much later, the term palenque becamesynonymous with freedom. From the many palenques thatexisted in the Colonial ... it.MethodsDescription of the study area The geographical region under study includes severalsmall towns of the department of Bol ívar in the norther ncoast of Colombia (Figure 1). The study region is...
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Báo cáo y học: " Transcriptional control in the prereplicative phase of T4 development" pot
... termination and increased mRNA stabi-lity by RNA-binding proteins are involved in the regu-lation of gene expression in eukaryotes and theirviruses [135,136]. A thorough investigation of theseprocesses ... [86]. In fact, expression of severalearly genes increase in the T4 motA- infection, presum-ably because of a delay in the shift from early to middletranscription [87]. MotA is a basic protein of ... Thus, further work is needed to clarify the role of the of AsiA C-terminal region. Finally, very recent workhas shown that the inability of T4 motA mutants toplate on the TabG strain arises...
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Báo cáo y học: " Health status in the TORCH study of COPD: treatment efficacy and other determinants of change" pps
... domain scoresare shown in Figure 1. The pattern of change in the pla-cebo arm differed between domains: the improvement in Symptoms score over the first 6 months was sustained for the rest of the ... particu-larly the Symptoms domain, which may continue forove r 3 months [14 ]. In TORCH, patients were excludedonly if they had an exacerbation requiring treatmentduring the 2-week run -in period, so the ... ques-tionnaire during the study. Suitable translations werenot available for five langua ges at the start of the study.Furthermore, where translations were available, during the years from study inception...
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Báo cáo y học: " Ethnic differences in the adaptation rate of HIV gp120 from a vaccine trial" ppsx
... correction in HYPHY [14]. In the latter case, we took recombinationinto account by first detecting recombination breakpointswith GARD [15], and then estimating the dN/dS ratiosindependently for ... that the rate of virus evolution is greater in this group than in othervolunteers. Differences in immune response to HIV-1infection have been pointed out by the rgp120 HIV Vac-cine Study Group ... PAML and HYPHY, respectively) than the otherraces (0.65–1.01, 0.84–1.14 and 0.73–1.56, respectively).These results might indicate that natural differences in the immune response may have increased...
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Báo cáo y học: "Programme costs in the economic evaluation of health interventions" docx
... run at 80% capacity, since more remote areasmay have a very low population density. Since costs of training of health care professionals are independent of population density, these costs – expressed ... suit the particularities of their own setting. In adapting these tools, analysts have to assess if the assumptions outlined in this paper are appropriate fortheir own setting. The following list ... costsconsist of the cost of transporting goods to a country(c.i.f./f.o.b.) and transporting goods within a country (the domestic margin).Adjusting prices for traded goods The calculation of the cost of...
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Báo cáo y học: "Saponin accumulation in the seedling root of Panax notoginseng" potx
... all these five saponins were detected in the root. Then, with the growth of seedling, the sapo-nin contents increased rapidly in the root. The accumu-lation showed a time-dependent increment of ... [11].Allthesefindingssuggestthatsaponinsmaynotserveas the nutrient storage in the seed. The protective func-tions of saponins in other plants are reported [13,14]. The role of this kind of secondary ... notdetected in P. notoginseng seed. The formation of sapo-nins in root is a gradual process. The synthesis andaccumulation of saponins began after germination andcontinued with the growth of seedling....
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