Báo cáo y học: "Coding region structural heterogeneity and turnover of transcription start sites contribute to divergence in expression between duplicate genes" docx

... largest comprehensive expression profile of human genes available to date, and assessed the contributions of TSS turnover, cod- ing sequence structural heterogeneity, and TE integration to divergence in duplicate ... element insertions on the divergence of duplicate gene expression. Conclusions: Our results suggest that turnover of transcription start...

Ngày tải lên: 14/08/2014, 21:20

... culture center, Institute of Microbiology and Epidemiology, Academy of Military Medical Science, China; c Jing a. Department of Microbiology, Third Military Medical University, China; d Bacterial ... LB medium. Electron microscopy To examine phage LSB-1 morphology, 50 μl of purified viral stock solution was fixed by addition of 50 μlof 0.5% glutaraldehyde in 4% paraformaldehy...

Ngày tải lên: 12/08/2014, 01:22

... Simons, K. (1999) Clusters of glycolipid and glycosylphosphatidyl-inositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. ... stimulated tyrosine-phosphorylation of STATs IL-2 induced tyrosine phosphorylation of STAT3 (and STAT5) was followed by flow cytometry as described previ- ously for STAT1 [32]. Brie y...

Ngày tải lên: 17/03/2014, 23:20

... expressed in airway epithelial cells and could contribute to the pathogenesis of COPD by amplifying cigarette smoke–induced and infection-induced inflam- matory reactions, leading to lung injury. 92 Calgranulins may ... abundantly in inflammatory leukocytes, includ- ing neutrophils. 71,72 PDE4 inhibitors have a variety of anti- inflammatory effects on neutrophils, including...

Ngày tải lên: 08/08/2014, 21:20

... in the current studies upon loading to erythrocytes. The erythrocytes were classified into; control erythrocytes, erythrocytes incubated with either 2 mM of PS or 2 mM of PQ, and erythrocytes ... susceptibility of erythrocytes to hemolysis in presence of primaquine was greater than that of control in ad- dition to pravastatin treated erythrocytes. This find- ing are...

Ngày tải lên: 25/10/2012, 11:40

... release of newly synthesized sulphated glycosaminoglycan and collagen into the media, whereas inhibition of PKR in sphingomyelinase-treated cells reduced the level of newly synthesized sulphated glycosaminoglycan ... for 7 days with sphingomyelinase to increase endogenous levels of ceramide. To inhibit PKR, 2-aminopurine was added to duplicate cultures. De novo sulphated g...

Ngày tải lên: 09/08/2014, 08:22

... J-PR contributed to study design, acquisition of data, analysis and interpretation of data, and sta- tistical analysis. M-JB and FA contributed to acquisition of data and to analysis and interpretation ... including worsening of pain at 24 months. Competing interests JFB, GAC, and JMM declare that they have financial compet- ing interests as employees of and/ or h...

Ngày tải lên: 09/08/2014, 10:20

... risk of triggering an immune response finally culminating in synovitis. However, genetic susceptibility factors of the host are also playing an important role particularly in persistent infections ... patients may have been asymptomatic, or the preceding gastrointestinal symptoms may have been mild and overlooked by the patients [3]. It is possible that enteric organisms may migrate...

Ngày tải lên: 09/08/2014, 14:22

... translating basic research findings into the clinic is partially due to a discontinuity of methods between the discovery phase and the validation phase. The methods used most commonly in the discovery ... treatment of genomic DNA to detect DNA methylation indirectly. However, they differ in the way they interrogate the amount of DNA methylation, leading to spe- cific exper...

Ngày tải lên: 09/08/2014, 20:20

... adenines were highly likely to be cytosines at low quality, errors were closer to uniform at high quality positions in the read. Finally, error rates varied from lane to lane within a sequencing ... confound ana- lyzes by introducing false polymorphisms and fragment- ing genome assemblies. The Quake system detects and corrects sequencing errors by using the redundancy inherent in...

Ngày tải lên: 09/08/2014, 22:23