Báo cáo y học: "Insight into the molecular requirements for pathogenicity of Fusarium oxysporum" pdf

... Interestingly, one of the F. oxyspo- rum pathogenicity mutants identified in this study has com- pletely lost FOXG_08594. The product of this gene shows high homology to one of the components of the ... Ma for mapping the potential pathogenicity genes on the F. oxysporum physical map and Bir- gitt Oeser for computational support for the comparison of the M....

Ngày tải lên: 14/08/2014, 21:20

... project beyond the surrounding DNA. In the case of H3 and H4, specific lysine sidechains undergo acetylation, through the action of histone acetyltransferases, by way of acetyl coenzyme A, a step which ... collagen. The histone deacetylase inhibitors trichostatin A and butyrate were shown to drastically reduce expression of these enzymes relatively selectively, with concomitan...

Ngày tải lên: 09/08/2014, 06:23

... the guanidinium carbon of agmatine. Thus, the disruption of this hydrogen bond is the likely cause of the greately decreased catalytic efficiency of the D153N variant. Keywords: agmatinase; Asp153; ... indicating that the environ- ment of tryptophan residues is essentially conserved in the mutant enzyme. On the other hand, the absence of major differences in the...

Ngày tải lên: 21/02/2014, 01:21

... obtained in the forward reaction. Synthesis of the acrylodan conjugate of the AC -Y7 5C mutant A1mgÆmL )1 acrylodan stock solution (4.4 m M )indimeth- ylformamide was used for labeling. The AC -Y7 5C mutant (0.8 ... present only in the target cells. The C-terminal part is responsible for the hemolytic phenotype of B. pertussis,and for the translocation of the c...

Ngày tải lên: 07/03/2014, 15:20

... reaction mechanism of the hydrolysis of the cyclic nucleotide cAMP by PDE4B. The superfamily PDE enzymes play an important role in the signal transduction pathways to effectively terminate the second ... pathway for the cAMP hydrolysis in neutral solution is a direct nucleophilic attack on the phosphorus atom by a hydroxide anion, and that the hydrolysis proceeds by an S...

Ngày tải lên: 14/03/2014, 23:20

... (–) or in the presence of either: dimyristoyl phosphatidylcholine (Myr 2 -PCho), dimyristoyl phosphatidylethanol- amine (Myr 2 -PEtn), or dimyristoyl phosphatidylglycerol (Myr 2 - PGro). For spectra ... daphoenix@uclan.ac.uk Abbreviations:Myr 2 -PGro, dimyristoylglycerophosphoglycerol; Myr 2 -PCho, dimyristoylglycerophosphocholine; Myr 2 -PEtn, dimyristoylglycerophosphoethanolamine; FTI...

Ngày tải lên: 31/03/2014, 08:20

... the heterogeneity of the disease and the difficulty of predicting its progression. There is often disparity between the X-ray appearance and symptoms, and a lack of satisfactory markers for monitoring ... matrix, possibly by perlecan. Damaging the tissue by simple cutting releases the growth factor very rapidly and activates the chondrocytes. bFGF upregulates synthesis...

Ngày tải lên: 09/08/2014, 01:23

... this study we sought to address the role of cell wall strength and loosening in the control of the early steps of hair formation by utilizing the prc1-1 mutant in the CesA6 cellulose synthesis ... 5D) although the proportion of trichoblasts forming a root hair was less than half that of either the wild-type or prc1- 1 single mutant roots (Fig. 5E). The morphology of...

Ngày tải lên: 12/08/2014, 05:20

... (Figure A summary of expression profiles for the highly disordered proteinsFigure 3 A summary of expression profiles for the highly disordered proteins. (a) The heat map displays four distinct ... stability values. (d) The percentage of transcripts likely to be regulated by miRNA (y- axis) for the transcripts encoding the highly ordered and the highly disordered prot...

Ngày tải lên: 14/08/2014, 21:20

... complex of the respiratory chains of mitochondria and many bacteria [1–4]. It catalyzes the reduction of oxygen to water, coupling the free energy of this reaction to the generation of a proton gradient ... bacterial enzyme by stripping subunits III and IV off the native complex, and by further destroying a large part of the acidic lobe(s) of the docking site of...

Ngày tải lên: 22/02/2014, 07:20