Báo cáo y học: "Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo" ppsx

... multi- ple signaling pathways, the ability to detect the activation sta- tus of individual pathways within a complex network of other pathways in the cell is of paramount importance. In this man- ner, ... pathway activation in mammary glands expressing activated Ras for 96 h and in mammary tumors induced by chronic Ras activation. (b) Western analysis showing incr...

Ngày tải lên: 14/08/2014, 21:20

... standard curve. The analytical reproducibility of all aRibP assays was evaluated by repeated testing of two serum samples (10 determinations each) in the same run, giving intraas- say coefficients of variation ... signifi- cantly lower lymphocytes than aRibP R 0 - lupus patients. Interestingly, a P0-like protein is also detectable in the plasma membranes of different cells, includ...

Ngày tải lên: 12/08/2014, 15:22

... for their tinnitus. Tinnitus matching is performed by presenting sounds to the ear in which the tinnitus is not perceived, and both tinnitus pitch and tinnitus intensity (above hearing threshold) ... perceived tinnitus. Technical investigations include MRI of the brain and posterior fossa, pure tone and speech audiometry, Auditory Brainstem Response (ABR) and tympanometry. Assess...

Ngày tải lên: 08/08/2014, 16:23

... expectancy, thymic involution, and antigen exposures, the development of CD4 + CD25 + T R cells may occur in the periphery in man. Induction of CD4 + CD25 + T R cells in the periphery The induction of ... capable of directly generating Tr1 cells in vitro and in vivo, and may represent a naturally occurring dendritic cell subset involved in eliciting tolerance in vivo [41...

Ngày tải lên: 09/08/2014, 01:24

... disease severity of CIA in mice. In our study we used a well-established model of smoke-induced emphysema in mice [20,21]. In the course of this model, mice develop a progressive infiltration of inflammatory ... Therapy Vol 11 No 3 Lindblad et al. Page 2 of 8 (page number not for citation purposes) the stimulating effect of nicotine on collagen and gly- cosaminoglycan synt...

Ngày tải lên: 09/08/2014, 14:21

... disabling dis- ease are likely to lead a less active lifestyle, resulting in increased obesity and alterations in the lipid profile [42,43]. One of the most interesting findings from this study, ... WHO definition. This phenomenon may be explained by differences in the compo- nents and cut-off values used in the definitions. The WHO is the only definition to include albumin/creatini...

Ngày tải lên: 09/08/2014, 14:22

... chemical-genetics system to modulate the activity of a protein kinase by mutating an amino acid residue in its ATP-binding pocket (the ‘gate- keeper’ residue), allowing the resulting kinase - often called ... essentially all cellular processes, including the DNA-damage response (DDR). Key aspects of the DDR are the slow- ing or stopping of cell cycle progression by DNA- damage checkpo...

Ngày tải lên: 09/08/2014, 23:20

... methy- lated- and u nmethylated-specific primers, respectively [23]. Flow Cytometry for DNA Ploidy 703 of 1,173 tumors were available to examine the status of DNA ploidy using flow cytometry by ... Molecular karyotype profiling of the two subtypes of sporadic CRCs revealed significant differences in the extent and distr ibution of CN altera- tions in the cancer genome. Combining...

Ngày tải lên: 10/08/2014, 05:21

... potential indicator by defining its numerator and denominator. Phase 2: Applicability test of potential quality indicators Before the indicator set is u sed in a specific setting, its applicability in ... similarity to the quality indicators in our study namely indicator 1 (’HIV screen- ing in all pregnant women’), indicator 5 (’ preconcepti on counselling’ ), indicator 9 (’antiretr...

Ngày tải lên: 10/08/2014, 05:22

... often results not only in paralysis but also in the loss of sensation and reflexes below the point of injury, such as bowel and blad- der control. Dysfunction of the urinary system is one of ... pathophysiology of bladder dysfunction in SCI patients is significant. We investigated the pathophysiology of spinal bladder dysfunction in a rat contusion model of SCI. Con...

Ngày tải lên: 11/08/2014, 03:20