Báo cáo y học: "Core promoters are predicted by their distinct physicochemi" pdf

... individual physicochemical property of DNA. Genome Biology 2008, 9:R178 Open Access 2008Bricket al.Volume 9, Issue 12, Article R178 Method Core promoters are predicted by their distinct physicochemical ... property 14 - AT and GC type curvature propensity [29] - correctly predict fewer promoters (sensitivity = 0.09), but have a specificity of 1.00, meaning that IG and EX sequenc...

Ngày tải lên: 14/08/2014, 21:20

... pooled and lyophilized to yield with solid of purity exceeding 99% as assessed by HPLC analysis of the final m aterials. I dentity and purity of peptide was confirmed by mass spectrometry, utilizing ... & Chang, C.D. (1979) So lid phase synthesis without repetitive hydrolysis. Preparation o f leucylalanyl-glycyl- valine using 9-fluorenylmethyloxy- carbonylamino acids. Int. J. Peptide Pro...

Ngày tải lên: 22/02/2014, 04:20

... was kindly provided by U. Moe ¨ ns (University of Tromso, Norway) [31]. The expression vector pcDNA3-myc was generated by inserting a BamHI–EcoRI fragment that codes for six copies of myc epitope, ... affinity for SRF [30], was also analyzed because preliminary studies had shown that this promoter is activated by SRF co-expression. The activity obtained for these promoters was markedly...

Ngày tải lên: 22/02/2014, 07:20

... which may include the following symptoms: flushing, arthralgias, capillary leak syndrome with pulmonary edema, encephalopathy, and severe gastrointestinal symptoms Type β Hypersensitivity Immediate ... syndrome Symptoms will depend on the cytokine or cytokine being targeted e.g., high levels of INF-α may cause 'flu-like symptoms and anti- CD3 (muromunab) may induce cytokine release s...

Ngày tải lên: 08/08/2014, 21:20

... the disease are identifying susceptibility genes where mutations may increase disease risks by changing enzymatic activity or modulating neuronal signaling. The development of antipsychotics relies ... system causes symptoms of schizophrenia; oligodendrocytic computation capacity theory [17] The NPY gene is a susceptibility gene for schizophrenia; reduction of levels of neuropeptide Y...

Ngày tải lên: 08/08/2014, 23:21

... this property. Cytokine response to predicted DR4 restricted T-cell epitopes Because cytokine production by activated T cells is believed to play an integral role in the inflammatory response ... 55:40-46. 24. Murray JS: How the MHC selects Th1/Th2 immunity. Immunol Today 1998, 19:157-163. 25. Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joac...

Ngày tải lên: 09/08/2014, 01:21

... cells. However, at Abstract T-helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce antibodies, by producing cytokines that activate e ector cells involved ... recognition of systemically expressed antigens by T cells can induce arthritis. Systemic autoimmune responses towards glucose-6-phosphate isomerase [4,5], fi brinogen [6], or transgenica...

Ngày tải lên: 12/08/2014, 12:20

... heterozygote genotype with the minor homozygote genotype as they showed a similar effect in primary analysis. Statistical analysis was performed using SAS software (SAS Institute, Cary, N.C.). Haplotype ... by SNPs reported in previous studies (25 SNPs). SNP genotyping was performed using the MassARRAY SNP genotyping sys- tem (Sequenom, Inc., San Diego CA) which utilizes a primer extension...

Ngày tải lên: 12/08/2014, 14:20

... MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H: Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008, 180:7423-7430. ... Th17-associated cytokines, play a prominent role in the inflamed synovium by perpetuating the inflammatory milieu observed in arthritis [6]. Interestingly, Concentrations of IL-17...

Ngày tải lên: 12/08/2014, 18:20

... aggravate problems by rapidly diminishing the numbers of available physicians. Although society has the right to demand service from physicians during a health care crisis, physicians have the reciprocal ... acute respiratory syndrome) epidemic, many health care profes- sionals will wonder whether we are well prepared to cope with the anticipated influenza pandemic [2,3]. Worldwide, healt...

Ngày tải lên: 13/08/2014, 11:22