Báo cáo y học: " Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes" docx
Báo cáo y học: " Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes" docx
... hypoth-esis of common sense-antisense pairing between transcripts derived from protein coding genes is viable, it is by no meansproven. For one thing, there remains a conceptual difficulty.If ... regulatory RNA. Is it likely that coding RNAs mightregulate each other by sense-antisense pairing? More gener-ally, if we are blind to whether an RNA is protein coding ornot, how commonly do we ... sequence sense-antisense regulation between transcripts originating from protein coding genes.Results Short pairs in human transcripts In asking whether sense-antisense pairs are enriched inhuman coding mRNAs, we...
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Báo cáo Y học: Evidence for general stabilization of mRNAs in response to UV light pdf
... USA, andG. Dreyfuss, University of Pennsylvania School ofMedicine, Philadelphia, PA, USA, respectively.Transfections and reporter assays for mRNA stabilityTransient transfections by the calcium ... lM) as indicated. Cytoplasmic lysates were assayed for GFP-MKK62E protein by Western blot,and for activation of the p38 MAP kinase/MK2 pathway by in vitro kinase assays with recombinant HSP27 ... 5839 for UV-induced stabilization. The effect of the p38 MAPkinase pathway on the stability of endogenous histonemRNAwasassayedincellsstablytransfectedwithaplasmid encoding constitutively active...
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Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps
... DMARDsuch as hydroxychloroquine in limiting the X-ray progres-sion in early RA [6]. Benefits from early DMARD therapyextend over 5 years. Borg and colleagues [7] comparedearly treatment with ... frequent withcombination therapy at 2 years. Subsequent analysesfound that delaying DMARD therapy by only a few monthsdecreased the ability of the monotherapy to induce remis-sion [20]. The ... strong support for early DMARD therapy. Neverthe-less, the benefits of early DMARDs became less obviouswith time. By 5 years patients receiving early DMARDshad similar disease activity and comparable...
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Báo cáo y học: "Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis" pdf
... Roubichaud GA, Roy J, Cantin R, Tremblay MJ, Tess-ier PA: HIV-1 Transcription and virus production are bothaccentuated by the proinflammatory myeloid-related proteinsin human CD4+ T lymphocytes. J ... 95°C step for 10 minutes (for Taqactivation), followed by 40 cycles of 95°C for 15 seconds,60°C for 1 minute, and then a final melting curve analysis witha ramp from 60°C to 95°C for 20 minutes. ... tube. Red cells wereremoved from the granulocytes by hypotonic cell lysis as rec-ommended by the manufacturer, and granulocytes wereplaced immediately in Trizol reagent for RNA purification.Plasma...
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Báo cáo y học: " Evidence for natural antisense transcript-mediated inhibition of microRNA function" ppsx
... natural antisense transcripts, most of which appear to be non -protein- coding RNAs (ncRNAs). We have recently identified and characterized a highly conserved non -coding antisense transcript for ... bioinformatics analyses revealed a theoretical basis for many other potential interactions between natural antisense transcripts and miRNAs at the binding sites of the latter.BackgroundRecent transcriptomic ... including those that form complex interleavedand overlapping patterns with coding transcripts [5-7]. Natural antisense transcripts (NATs) are endogenousRNA molecules transcribed from the opposite...
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Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx
... Biology, Indiana University, Bloomington, IN, USA, 3Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics, Department of Psychiatry, Indiana ... Fur-ther evidence for family-genetic risk factors in attention def-icit hyperactivity disorder. Patterns of comorbidity inprobands and relatives in psychiatrically and pediatricallyreferred ... no evidence for association between pediatric bipolar disorder and any RORA SNPs orhaplotype blocks after multiple-test correction. In addition, we found no strong evidence for associationbetween...
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Báo cáo y học: " Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site" ppt
... transport of RNA transcribed in the same locus ofchromosome from the nucleus to their destination in thecellular cytoplasm. In the cytoplasm, RNA could bequickly bound by viral proteins before two ... cytoplasm. For example, HIV-1 encodes the virus-specific protein Revwhich selectively transports the unspliced viral RNAs from the nucleus to cytoplasm [25]. Moreover, unspliced HIV-1 RNAs form ... with equal efficiency. PCR products obtained from virion RNA for the two cell clones generated bysequential transfection and two clones generated byPCR analysis of plasmid DNA transfected into...
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Báo cáo y học: "Model for predicting short-term mortality of severe sepsis" ppt
... may further elevate the risk for subsequent acute illnesses, thereby initiating a spiral of eventsthat eventually causes death [23]. Therefore, a reasonablehypothesis is that early mortality ... manuscript.Key messages• We developed a model for predicting short- term (14 days) mortality after each episode of severe sepsis, using readily available variables. The model proved very accurate for ... not for citation purposes)of 700 ml/day or less in a patient not previously undergoinghaemodialysis for chronic renal failure; respiratory dysfunctionwas a partial pressure of arterial oxygen...
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Báo cáo y học: " Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi" potx
... secondary metabolism gene cluster of M. griseacomprises 15 genes: ACE1 and SYN2 are PKS-NRPS hybridgenes; RAP1 and RAP2 code for enoyl reductases; CYP1-CYP4 for cytochrome P450 monoxygenases; ... ORFZ for an α/β-hydrolase; OXR1 and OXR2 for oxidoreductases; MFS1 codes for a transporter in the MFS superfamily; BC2 codes for abinuclear zinc finger transcription factor; OME1 codes for anO-methyl ... involved hyphal fusion between species, or endocytosis.Our inference of HGT is valid only if the Sordariomycete andEurotiomycete clades are monophyletic as shown in Figure 1,but their monophyly is...
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Báo cáo y học: "Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria" pps
... chosen based on the proximity that representatives from A. tumefaciens have to genes.serCU Y UUUUGUUUCCCCCYYCURAU Y GCRRG Y Y5′YGYY Y YY Y TerminatorAAGCRYRYGCGCACGCCCACA5′RUUAGCAUGUGGG ... mix-tures by the reaction of S-adenosylhomocysteine derivatives[46,47] and excess methyl iodide [48].Equilibrium dialysisAssays were performed by adding 100 nM S-adenosyl-L-methionine-(methyl-3H) ... riboswitches.HomoserineO-succinyl-L-homoserineL-homocysteineCystathioninemetAO-acetyl-L-homoserinemetXmetZmetCmetBmetBmetHmetEmetKS-adenosyl-L-methionineL-methionineP2aP3P2P1AGARUUARUACGAGP4CAGUCACCGUGRC Y AACGCGU Y RRRCUGRAGCR Y AGACGGRR Y GGCCGCAG Y GRSAM-I5′ Y GGGA Y UUURCCR Y YRRUUGCRAAAAAGCUAAARRP1P25′SAM-ISAM-IICRSAM-II...
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