Báo cáo y học: "Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip" pptx
Báo cáo y học: "Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip" pptx
... R166ResearchEgr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chipShilpi Arora*, Yipeng Wang*†, Zhenyu Jia*, Saynur Vardar-Sengul*‡, Ayla ... effector of the Map kinase/ERKpathway, mediator of a variety of growth factor receptors such as the epidermal growth factor receptor (EGFR) [17]. Activa-tion of the EGFR leads to rapid expression of ... previously to verifyChIP-Chip microarray analysis as well as to measure the gene expression changes of the target genes [24,43,46]. To validate the promoter array results, primers for 25 genes...
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Báo cáo y học: "Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"
... Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary Corresponding address: Andrew E. Czeizel Foundation for the Community Control of Hereditary Diseases, 1148 Budapest, ... evaluated, the period of study (only at birth or in early neonatal period or prenatal or the whole infant period are included), the completeness of ascertainment, the diagnostic skill of experts, ... characteristics of the study population, etc. In Hungary the total prevalence of congenital abnormalities was 66.83 per 1000 informative offspring in the 1980s and within this, the total rate of major...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... certainty that the effect is a real one. Secondly, it could be the case that the trangene molecules bound only weakly to the sperm cells, such that only direct delivery (by ICSI) permitted the ... transgenes, derived from the same (syngenic) laboratory animal strain as the target animal, contain homology blocks that are genetically identical (or virtually identical) to the target homology ... gene therapy. The lack of human ESCs leaves NT-based gene transfer as the only method that might be able to permit gene targeting in human germline gene therapy. NT could probably be readily applied...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... guanidinium carbon of agmatine. Thus, the disruption of this hydrogen bond is the likely cause of the greately decreased catalytic efficiency of the D153N variant.Keywords: agmatinase; Asp153; site-directed ... DISCUSSION By site-directed mutagenesis, a D153N mutant form of E. coli agmatinase was obtained. The mutant enzymeretained about 5% of wild-type activity and it was equallyactive when assayed in the ... pasted into the structural alignment. The alignment was then corrected by hand. Since the sequences of the two arginases andagmatinase greately differ in the N terminal region, the agmatinase...
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Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx
... Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(g,g-dimethylallyl) tryptophan synthasefrom Claviceps, the first pathway-specific enzyme in ergot alkaloidbiosynthesis. J. Am. ... HA-hydrogen of IPP. Inboth cases, scrambling of the label takes place within the IPPpool and the error is then transcribed into the DMAPP pool by the normal action of the isomerase. The validity of the proposed ... 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, 4-diphosphocytidyl-2C-methyl-D-erythritolkinase and 2C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase [24–26] (Fig. 1). In the meantime, some of...
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Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
... Escherichia coli as fusion proteins with glutathione S-transferase using the pGEX-3X plasmid, and purified as described previously [4]. The purity of both apoE3 and apoE4 as assessed by SDS/PAGE was estimated ... between the densityand molar mass of the fractionated emulsion particles,we assumed a spherical monolayer of Myr2Gro-PChosurrounding a core of TO, supported by transmissionelectron microscopy ... Consequently, the relationship between density of the particles as afunction of particle mass was determined using valuesfor M andvv reported by [29], calculated from the ratio of phospholipid...
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Báo cáo y học: Advances in the Surgical Management of Chronic Rhinosinusitis" pot
... technology has been,theoretically, to increase the safety and com-pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health centres ... tissuecontraction. Obviously, another indication forrevision surgery is recurrent polyp disease that can-not be managed medically or in the office.Technical State of the Art The current state of the art in ... that furthermedical therapy will still be required to managetheir disease but that marsupialization of the eth-moid sinus cavity with surgical widening of the ostia of the secondary sinuses...
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Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx
... diseases of aging for whichthere is little, if any, effective treatment. It accounts for moremobility disability in the elderly than any other disease.Symptomatic knee OA affects roughly 12% of ... currentlyongoing. The effects of patellar braces on patellarmalalignment are also unclear, but braces may push the patella into the trochlear groove [67], thereby increasing the contact area of the ... found that the neoprenesleeve relieved pain better than nothing but that the bracerelieved pain better than either of the other two treatments as measured by the WOMAC, a survey that asks persons...
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Báo cáo y học: "Developments in the clinical understanding of rheumatoid arthritis" ppt
... consequence of the activation of many cell populationsand, ultimately, of the upregulation of proinflammatory cyto-kines [19,20]. By whichever means they themselves becomeactivated, they induce ... characteristics of the diseaseA new look at assessing active diseaseClinical fact 1Composite indices are the best depicters of disease activity. The degree of disease activityat the start of a disease-modifying ... such as cardiovascular diseaseand lymphoma, and economic consequences,including loss of working capacity, areassociated primarily with the severity of RA as manifested by chronic high disease...
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Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf
... sensitivity of the test for antibodies in RA wasincreased from 24% to 88% when the intact CII moleculewas replaced by CB10 and, notably, this was not at the expense of specificity, which was 94% ... con-trols. The use of these sera for the present study wasapproved by the Standing Committee on Ethics inResearch involving Humans of Monash University.Preparation of type II collagenCII was prepared ... wasused.Discussion The most significant finding from our study was that in RA the use in an ELISA of fragments of the intact CII molecule,particularly CB10, as antigen markedly increased the...
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