Báo cáo y học: "Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip" pptx

... R166 Research Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip Shilpi Arora * , Yipeng Wang *† , Zhenyu Jia * , Saynur Vardar-Sengul *‡ , Ayla ... effector of the Map kinase/ERK pathway, mediator of a variety of growth factor receptors such as the epidermal growth factor receptor (EGFR) [17]....

Ngày tải lên: 14/08/2014, 21:20

... Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary Corresponding address: Andrew E. Czeizel Foundation for the Community Control of Hereditary Diseases, 1148 Budapest, ... evaluated, the period of study (only at birth or in early neonatal period or prenatal or the whole infant period are included), the completeness of ascertainment, the dia...

Ngày tải lên: 02/11/2012, 11:12

... certainty that the effect is a real one. Secondly, it could be the case that the trangene molecules bound only weakly to the sperm cells, such that only direct delivery (by ICSI) permitted the ... transgenes, derived from the same (syngenic) laboratory animal strain as the target animal, contain homology blocks that are genetically identical (or virtually identical) to...

Ngày tải lên: 03/11/2012, 10:01

... guanidinium carbon of agmatine. Thus, the disruption of this hydrogen bond is the likely cause of the greately decreased catalytic efficiency of the D153N variant. Keywords: agmatinase; Asp153; site-directed ... DISCUSSION By site-directed mutagenesis, a D153N mutant form of E. coli agmatinase was obtained. The mutant enzyme retained about 5% of wild-type activity and it...

Ngày tải lên: 21/02/2014, 01:21

... Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(g,g-dimethylallyl) tryptophan synthase from Claviceps, the first pathway-specific enzyme in ergot alkaloid biosynthesis. J. Am. ... H A -hydrogen of IPP. In both cases, scrambling of the label takes place within the IPP pool and the error is then transcribed into the DMAPP pool by the normal action of...

Ngày tải lên: 22/02/2014, 07:20

... Escherichia coli as fusion proteins with glutathione S-transferase using the pGEX-3X plasmid, and purified as described previously [4]. The purity of both apoE3 and apoE4 as assessed by SDS/ PAGE was estimated ... between the density and molar mass of the fractionated emulsion particles, we assumed a spherical monolayer of Myr 2 Gro-PCho surrounding a core of TO, suppor...

Ngày tải lên: 08/03/2014, 09:20

... technology has been, theoretically, to increase the safety and com- pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health centres ... tissue contraction. Obviously, another indication for revision surgery is recurrent polyp disease that can- not be managed medically or in the office. Technical State of...

Ngày tải lên: 08/08/2014, 20:23

... diseases of aging for which there is little, if any, effective treatment. It accounts for more mobility disability in the elderly than any other disease. Symptomatic knee OA affects roughly 12% of ... currently ongoing. The effects of patellar braces on patellar malalignment are also unclear, but braces may push the patella into the trochlear groove [67], thereby increasing the...

Ngày tải lên: 09/08/2014, 01:22

... consequence of the activation of many cell populations and, ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce ... characteristics of the disease A new look at assessing active disease Clinical fact 1 Composite indices are the best depicters of disease activity. The degree of diseas...

Ngày tải lên: 09/08/2014, 01:22

... sensitivity of the test for antibodies in RA was increased from 24% to 88% when the intact CII molecule was replaced by CB10 and, notably, this was not at the expense of specificity, which was 94% ... con- trols. The use of these sera for the present study was approved by the Standing Committee on Ethics in Research involving Humans of Monash University. Preparation o...

Ngày tải lên: 09/08/2014, 01:23