... of intracellularsignaling of the Jak–STAT pathway used by several cyto-kines. They act by inhibiting the kinase activity, by competingwith substrates needed for signal transduction, and bytargeting ... that the main problem is in fact the inhibition of repair activity. Any type of chronic joint inflammation, whetherinfectious, inflammatory, or autoimmune, will result in jointdestruction within ... part by the uncon-trolled production of cytokines. Furthermore, depending on the stage of inflammation or the biological effect underscrutiny, the same cytokine may have proinflammatory or anti-inflammatory...