Báo cáo y học: "Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas" ppsx

... mechanisms that increase c-MYC protein abundance/stability or simply c-MYC activity are involved in MYCN/c-MYC target gene activation in stage 4 tumors. Our data are in line with a model where ... for one and >2-fold enrichment of at least one of the two neighboring probes. MYCN/c-MYC- binding is color-coded as follows: blue, c-MYC binding; red, MYCN/c-MYC binding; dark...

Ngày tải lên: 14/08/2014, 21:20

... factors for it CVD was defined as a verified medical history of coronary, cer- ebral or peripheral arterial disease. Coronary artery disease included a history of myocardial infarction, a coronary ... co-morbidity [8,9]. Third, RA itself could be responsible for the excess in cardiovascular morbidity and mortality, either by a decreased functional capacity [10], or by the underlying inf...

Ngày tải lên: 09/08/2014, 08:22

... small. The influence of prior ARV therapy (not including INIs) was not addressed by Rhee et al. Interestingly, we found that previous ARV therapy was associated with greater IN divergence (the mean intra-subtype ... in our study occurred in samples from previously ARV-treated individ- uals, suggesting that previous therapy may result in reduced INI efficacy, and further supporting...

Ngày tải lên: 13/08/2014, 05:21

... IU/mL. Body weight measurement and laboratory data were collected and compared at the beginning and at the end of therapy. The Knodell scoring sys- tem for liver biopsy (obtained at baseline) result ... once weekly injections of pegylated interferon alfa-2a or alfa 2b (180 μg) plus ribavirin (1000 or 1200 mg/day in divided dose) for 48 weeks. Patients infected with HCV genotypes...

Ngày tải lên: 26/10/2012, 09:39

... played by cytokines in the evolution of insulin resistance. Could hyperhomocysateineamia be a result of derangement of certain cytokine production? Abbreviations tHcy: total homocysteine; ... homocysteine levels in subjects with hyperinsulinemia. J Intern Med. 2000;247(2):287-94. 66. Fonseca VA, Fink LM, Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non-...

Ngày tải lên: 03/11/2012, 09:49

... Vgf immunoreactivity. Immunocytochemistry For semiquantitative assessment of Vgf in spinal cord motorneurons, immunohistochemistry was per- formed as previously reported [21] with minor modi- fications. ... content in the serum, in the CSF, and in spinal cord motorneurons may be a biological diagnostic index for ALS. It remains to be directly tested whether restoring Vgf expr...

Ngày tải lên: 03/11/2012, 10:52

... haplotype may be associated with primary knee OA, and genetic variations in the ER-α gene may be involved in OA. Keywords: estrogen receptor, haplotype, knee osteoarthritis, polymorphism Introduction Osteoarthritis ... 4). Estrogen receptor-α gene polymorphisms and risk for functionally poor osteoarthritis OA patients who were functionally or symptomatically poor (poor index) were...

Ngày tải lên: 09/08/2014, 01:23

... levels are seen in individuals with the genotypes XA/XA and YA/O, whereas very low or undetectable serum MBL levels are seen in individuals with genotypes XA/O and O/O. Individuals with YA/YA and YA/XA ... SNPs was performed by allelic discrimination using a Taqman assay, using specific primers and minor groove binding probes for each SNP [14,33]. Genotyping was performed inde...

Ngày tải lên: 09/08/2014, 10:23

... 1.73). Additionally, treating LLI as a continuous variable and adjust- ing for age and sex, LLI was not associated with GTPS. Sep- arate regression analyses (1) without including leg length, (2) with indicator ... well as inform future research. Competing interests The authors declare that they have no competing interests. Authors' contributions NAS developed the study hypotheses...

Ngày tải lên: 09/08/2014, 10:23

... treated with IFN-α2a for 72 hours was examined by (e) flow cytometry with intracellular staining or (f) Western blotting with β- actin as a protein loading control. The experiments were performed ... other protein interaction partners to transport information into the nucleus. IFIT4 was markedly induced by IFN-α in normal PBMCs, indicating a role for IFIT4 as a down- stream effecto...

Ngày tải lên: 09/08/2014, 10:23