Báo cáo y học: " Identification of CDK2 substrates in human cell lysates" ppt

... networks. In this study, we report a method employing the Shokat strat- egy to identify direct cyclin A -CDK2 substrates in human cell lysates. CDK2 is activated by both the cyclin E and cyclin A subunits, ... 6Autophosphorylation of cyclin A -CDK2 in vitroAutophosphorylation of cyclin A -CDK2 in vitro.Click here for fileAdditional data file 7Cyclin B -CDK2 (F80A) and...

Ngày tải lên: 14/08/2014, 21:20

... 0310, Norway. 4 Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, Oslo, 0318, Norway. Authors’ contributions HE designed the study, and contributed the majority of data analysis and writing of ... resulting in the inhibition of apoptosis [29,30]. IKZF3 is located at the most common telomeric breakpoint of the ERBB2- amplicon [31]. Interestingly, our preli...

Ngày tải lên: 09/08/2014, 22:23

... DQDEPDA DYPYYPGE ARGA PRGVDS GRDEPDR DFPYYPGE ARPE PRPVDS DYDDRD DAPYYPGE ARAP PRVVPDSGGRGR DHDDRD DAAYYPGE ARAP RFAPDSAG R DRSIESD LYYPGE FRRSNFSPPQASSMKYEET DKSPEQE PYYPGE FQQS EHRNLRCEDG DKYDEPD ... in thematurevirionsandinthenuclei of infected cells from which they originate. There are three distinct types of capsid, A-, B- and C-capsids, in infected cells [6]. The B-capsids o...

Ngày tải lên: 12/08/2014, 01:21

... heterozygosity at individual loci. A subset of four cases showed loss of heterozygosity of 11p solely as a result of UPD, indicating that cells might not tolerate the haploinsufficiency generated by large ... the information provided by SNP arrays. To uncover novel signaling pathways in human cancers, they first examined the structural genomic aberrations of a cell line panel...

Ngày tải lên: 14/08/2014, 07:22

... CST2 Cystatin C* CST3 Cystatin S* CST4 Inter-alpha-trypsin inhibitor heavy chain H1* ITIH1 5 Inter-alpha-trypsin inhibitor heavy chain H2 † ITIH2 5 Inter-alpha-trypsin inhibitor heavy chain H4 † ITIH4 ... 5 Lipocalin 1* LCN1 5 Similar to Lipocalin 1 Lipocalin 2 LCN2 Latexin † LXN Prosaposin † PSAP Alpha-1-antitrypsin* SERPINA1 5 Alpha-1-antichymotrypsin* SERPINA3 2,5 Leukocyte elastase inhibi...

Ngày tải lên: 14/08/2014, 17:22

... markers of bone metabolism and are regulated in bone by pro-inflammatory cytokines. The objective of this study was to investigate the role of HNE in OA osteoblast metabolism by determining its ... A, Kawakami A, Aoyagi T, Kawabe Y, Eguchi K: Regulation of cyclooxygenase-2 expression in human osteoblastic cells by N-acetylcysteine. J Lab Clin Med 2000, 136:390-394. 19. Reinec...

Ngày tải lên: 09/08/2014, 08:22

... Working Party on Systemic Lupus Erythematosus: Morbidity and mortality in systemic lupus erythematosus during a 10- year period. A comparison of early and late manifestations in a cohort of 1000 patients. ... properly cited. Abstract Introduction Infections commonly complicate the course of systemic lupus erythematosus (SLE). Our aim is to investigate the clinical predictors of ma...

Ngày tải lên: 09/08/2014, 14:22

... case of sinus of valsava aneurysm in Blau syn- drome. In isolated unruptured aneurysms of a sinus of Valsalva without compromise of the aortic valve and/or the coronary ostia, repair may be accomplished ... first case of sinus of valsava aneurysm in Blau syndrome. We believe t hat this is some form autoimmune a ortitis, but further evidence is needed. Sinus of Valsalva a...

Ngày tải lên: 10/08/2014, 10:20

... Suzuki T, Fujisawa J, Inoue J, Yoshida M: Tax protein of human T -cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor κB and induces nuclear transloca- tion of transcription ... Okuma M, Uchiyama T: Tumorigenicity of human T -cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characteriza- tion of the cells pr...

Ngày tải lên: 13/08/2014, 13:20

... member of the low-density lipopro- tein receptor family. LR11 binds low-density lipoprotein, the major cholesterol-carrying lipoprotein of plasma, and trans- ports it into cells by endocytosis. Human ... lineagesCoeliminiation of functionally linked genes in the Diptera and Dro-sophila lineages.Click here for fileAdditional data File 6Phylogenetic analysis of Fboxo7, cdk4 and cycl...

Ngày tải lên: 14/08/2014, 08:20