Báo cáo y học: "he signature of long-standing balancing selection at the human defensin β-1 promoter" pptx
Báo cáo y học: "he signature of long-standing balancing selection at the human defensin β-1 promoter" pptx
... in the IIPGA. Inparticular, the 2 kb upstream of the translation initiation site of other innate immunity genes genotyped for AA and EAwere retrieved only if the initial ATG was located in the ... concerning the early epidemiological history of our predecessors; indeed, the timing of human population expansion has been matter of debate [71-73] and some uncertainty concerns the time of ori-gin of ... original work is properly cited. Balancing selection& lt;p>Analysis of the human beta defensin 1 promoter region in six human populations reveals a signature of balancing selection. </p>AbstractBackground:...
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Báo cáo y học: "he impact of sample storage time on estimates of association in biomarker discovery studies" doc
... motivated by a biomarker discoverystudy at the Medical University of Innsbruck that aimsto identify biomarkers to predict breast cancer recur-rence. In that study, among other investigations ... supported by the COMET Center ONCOTYROL and funded by the Federal Ministry for Transport Innovation and Technology (BMVIT) and the Federal Ministry of Economics and Labour /the Federal Ministry of Economy, ... sizes of the follow up stud y thatare too small (if associations are overestimated) or leadto the analysis of to o many costly biospecimens (if esti-mates are too low). Additionally, degradation...
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Báo cáo y học: "he effects of chemotherapeutics on cellular metabolism and consequent immune recognition" doc
... may be the dose of the agent or the nature of a given chemotherapeutic agent. Clearly, thereare cases where drugs at high doses have immunosuppres-sive effects (perhaps by direct cytotoxicity ... While we have not tested the ability of all drugs to promote immunogenicity, theseresuts may imply that the increase in the co-stimulatory sig-nal as a result of drug treatment is a general phenomenon.Which ... blocks three pathways of hyperglycaemic damage.Nature 2000, 404:787-790.31. Brand KA, Hermfisse U: Aerobic glycolysis by proliferating cells:a protective strategy against reactive oxygen species....
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Báo cáo y học: "he outcome of patients presenting to the emergency department with severe sepsis or septic shock" doc
... the prevalence of high-risk patients in need of early hemodynamicoptimization. This may explain why they strikingly found only50 patients over 3.5 years (14.2 per year) meeting criteria forsevere ... hospitalemergency department (ED) that sees 40,000 patients eachyear with a 30% admission rate. The lactate level of 4 mmol/l, as used in the EGDT study, wasinternally and externally validated. In their ... respected, theseretrospective data transmit other signals. The early use of vasopressors is not necessarily a sign of an aggressive level of care; it may be a sign of inadequate volume resuscitationand...
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Báo cáo y học: "he impact of the introduction of critical care outreach services in England: a multicentre interrupted time-series analys" pdf
... the source of admission to the unit and the National ConfidentialEnquiry into Perioperative Death classification of surgery, asdescribed previously [5].Survey data and other sources The results of ... appropriately during the working day, avert-ing the need to admit the patient as an emergency in the middle of the night. Alternatively, it is possible that in hospitalswith a CCOS that does ... activity. The use of such a system may lead to earlier intervention whena patient shows signs of deteriorating and may thereforereduce the CPR rate. A wide variety of track and trigger warn-ing systems...
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Báo cáo y học: "he effect of carbon dioxide on near-death experiences in out-of-hospital cardiac arrest survivors: a prospective observational study" pdf
... patients with return of spontaneous circulation, then the number of patientsdischarged from the hospital alive, and finally the number of patients that were included in the study.Table 1 Patients’ ... 74:215-221.2. Greyson B: A typology of near-death experiences. Am J Psychiatry 1985,142:967-969.3. Parnia S, Waller DG, Yeates R, Fenwick : A qualitative and quantitativestudy of the incidence, features ... the designing of the study protocol, supervised the study, interpreted the data,and made comments to the first and second drafts of the manuscript. SGwas involved in the designing of the study protocol,...
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Báo cáo y học: "Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryote" ppt
... selection may be linked to the codon usage pattern of halophilic prokaryotes.Conclusion The present study demonstrates the generality of the mecha-nisms of macromolecular adaptation of extreme ... walsbyi, the disadvantage of alow GC-genome is thought to be partly compensated for by the presence of a relatively higher number (four copies) of photolyases [21]. Our analysis reveals that the ... (Table 4). All of these findingsstrongly support the notion of convergent evolution not only at the level of proteome composition, but also at the level of genome organization of the microorganisms...
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Báo cáo Y học: Genomic organization of MUC4 mucin gene Towards the characterization of splice variants potx
... with the b-catenin [31].This interaction is regulated mainly by two mechanisms, via the phosphorylation status of each partner of the b-cateninpathwaycausedbytheGSK3b, or via the interaction of MUC1 ... establish the nature of the mechanismsresponsible for the diversity of transcripts. They weregenerated by the combination of either one or more eventsresulting in several mechanisms of alternative ... single cell type may result inmodulation of the properties of the molecule. On the otherhand, the alternative RNA splice forms may only functionto reduce the level of expression of the main form...
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Báo cáo y học: " A comparison of olanzapine and risperidone on the risk of psychiatric hospitalization in the naturalistic treatment of patients with schizophrenia" ppsx
... days of hospitaliza-tion at the end of each of the 12 months post initiationindicated that the average number of hospitalization daysfor the RIS-treated patients was 1.4 to 2.1 times that of the olanzapine ... study period (July 1997 to January2001) were likely to similarly impact the two treatmentgroups on the use of psychiatric resources. Of the patientswho were hospitalized at the time of initiation ... the olanzapine treatment group. By the end of the sixthmonth following initiation, the patients in the RIS-treat-ment group had a mean of 3.9 hospitalization days morethan the OLZ treated patients (mean...
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Báo cáo y học: "Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis" pptx
... & Therapy Vol 8 No 4 Dejaco et al.Page 4 of 6(page number not for citation purposes)Table 2. At the cutoff of 19.0 U/ml, both tests had an identicalsensitivity, but the specificity of the ... 23%–43% of patients with RA but in less than 8% of patients with non-RA and healthy controls by immunoblot-ting [11,13,15]. The objective of this study was to investigate the diagnostic accuracy of ... Amor B, CalinA, Cats A, Dijkmans B, Olivieri I, Pasero G, et al.: The EuropeanSpondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum...
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