Báo cáo y học: "Evolutionary rate and gene expression across different brain regions" ppt

... mammalian and human estimators) and in gene age. Evolutionary rate, gene age and gene expression in cortical vs sub-cortical regions We computed the correlation between the ER and gene expression ... study the evolutionary rates of genes expressed in 21 different human brain regions. We find that genes highly expressed in the more recent cortical regions of the brai...

Ngày tải lên: 14/08/2014, 21:20

... replication [3], and only a small fraction (typically around 10%) of the genes are highly transcribed. These ‘clumps’ or regions of highly expressed genes can be seen as dark bands in Figure 1, and some ... with highly expressed genes found by Jeong et al. [1]. However, the majority of cellular DNA is compacted transiently by chromatin proteins, and there are many regions that are not h...

Ngày tải lên: 14/08/2014, 14:21

... signifi- cance of differentially expressed genes, a gene ontology analysis was conducted using DAVID/EASE [12]. Pathway analysis and classification by gene ontology Regulated genes (R > 1.5-fold, ... culture and real- time PCR, analyzed gene array data and prepared the first draft of the manuscript. TA provided resources and performed gene expression analysis by Affimetri...

Ngày tải lên: 12/08/2014, 15:22

... [22] combined microarray analysis with electrophysiology and neurotransmitter immunocyto- chemistry to describe the variability within and between 12 known classes of forebrain neurons in mice. ... situ hybridization expression data in selected sections of whole mouse embryos for several thousand genes at embryonic day (E) 14.5 and augments these data with additional data for some gen...

Ngày tải lên: 14/08/2014, 07:21

... Biology 2009, 10:R35 Table 2 Multiple regression of genomic variables and rates of synonymous changes dS dS' Predictor YTN1 YTN2 YTN1 YTN2 Relationships between evolutionary rates and six ... dN-dS Predictor YTN1 YTN2 YTN1 YTN2 YTN1 YTN2 YTN1 YTN2 Relationships between evolutionary rates and six predictor variables Expression level -0.105 -0.022 -0.043 0.058 -0.051 0.061 -0.038 0...

Ngày tải lên: 14/08/2014, 21:20

... Costello, Anthony J Freemont and Judith A Hoyland Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Human and Medical Sciences, University of Manchester, ... TNF- α and TNF-R2 expressions were upregulated by both TNF-α and IL-β, whereas TNF-R1 expression was not significantly affected by either cytokine. IL-1 β and IL-1Ra expressions were...

Ngày tải lên: 09/08/2014, 14:20

... breast tumors. On the other hand, change in DNA copy number is only one way to alter expression of a gene and expression of other oncogenes is much less tightly linked to DNA copy number or amplification. ... amplicons in tumors. Passen- ger genes will confound efforts to identify candidate onco- genes by expression analyses alone. For example, several candidate driver genes for amp...

Ngày tải lên: 14/08/2014, 07:21

... of 47 eukaryotes and 223 prokaryotes obtained from the genome and draft genome sequences stored in the Kyoto Encyclopedia of Genes and Genomes (KEGG) GENES and DGENES databases [52] and the Ensembl ... their combinations by considering phyloge- netic trees for eukaryotes and prokaryotes. Because of the uncertainty of some phylogenetic relationships and the low coverage rate of...

Ngày tải lên: 14/08/2014, 07:21

... such and, potentially, surgery have on gene expression patterns in autopsy and resection sam- ples, respectively, differences between brain regions that exist in the living brain are mostly retained ... differences in expression between autopsy and resection samples in both brain regions cluster in functional categories as defined by the Gene Ontol- ogy (GO) consortium [12]...

Ngày tải lên: 14/08/2014, 16:20

... biotic stimuli and stress, cell commu- nication, carbohydrate and lipid metabolism, and for genes with hydrolase activity (Additional data file 3). Interestingly, genes of many of these classes ... duplications by using massively paral- lel signature sequencing (MPSS) data and concluded that, besides a significant portion of segmentally and tandemly duplicated genes with similar ex...

Ngày tải lên: 14/08/2014, 16:21