Báo cáo y học: "Preferential regulation of duplicated genes by microRNAs in mammals" ppt

... importance of such duplication Dynamic simulation of regulation of duplucate genes by microRNAFigure 5 Dynamic simulation of regulation of duplucate genes by microRNA. (a) A schematic diagram of a hypothetical ... of T1 so as to maintain a similar expression level of P. Mathematically, the topology of our proposed kinetic model is intrinsically stable with only...

Ngày tải lên: 14/08/2014, 20:22

... morphology after induction of differentiation of HL-60 cells by dimethylsulfoxide and TPA. (A) HL-60 cells cultured in RPMI for 3 days (control for B), followed by cytospin analysis and staining (·1000). ... Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may amplify the enzyme function. In this s...

Ngày tải lên: 17/03/2014, 23:20

... exogenous IFNγ in vitro inhibits murine osteoclasto- genesis by inducing the rapid degradation of the RANK adapter protein TRAF6, resulting in strong inhibition of RANKL- induced activation of NFκB ... surface by creating a sealing zone structure unique to the osteoclast. A ring of filamentous actin associates with the intracellular proteins vinculin, talin, α-actinin, and cor...

Ngày tải lên: 09/08/2014, 13:21

... University, Husargatan 3, SE-751 21 Uppsala, Sweden. § Key Laboratory of Zoonosis, Ministry of Education, Jilin University, Xi An Da Lu 5333, Changchun 130062, China. ¶ Laboratory of Parasitology, ... are known to interact with the host immune system [12]. These include the family of P. falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, employed by the parasite to sequ...

Ngày tải lên: 09/08/2014, 20:20

... prevalence of nasal symptoms and sinusitis, and nasal and bronchial inflammation coexist in smokers and is characterized by infiltration of CD8+ T lymphocytes [16]. In upper air- ways, CS may act ... effects of CS o n upper airways, especially in comparison to the lower airways. We therefore aimed to investigate the inflammatory response of the upper airways in a murine mode...

Ngày tải lên: 12/08/2014, 11:22

... wound healing. In addition, strong local in ammatory responses that are speci®c to cytokines such as interleukin-4, are capable in some cases of mediating regression of tumors [53,54]. In ammatory in ltrates ... of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Science and Technology, Okayama University, Japan; 2 Department of Biology, Facu...

Ngày tải lên: 17/03/2014, 17:20

... activity of the enzyme (data not shown). NDGA is known to inhibit the activity of lipoxygenase by binding to the reduced form (Fe 2+ )oftheenzyme thereby keeping it inactive [49]. In our experiments ... effective in inhibiting the activity of purified recombin- ant MTE-I in an in vitro assay performed in a Hepes-based buffer containing only KCl. Information about the tertiary...

Ngày tải lên: 08/03/2014, 09:20

... access [14]. In contrast to all Fe-hydrogenases including HydA of S. obliquus,the enzyme of C. reinhardtii has an interesting additional protein domain. A small insertion of 45 amino acids between ... synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA of C. reinhardtii, the first isolated gen...

Ngày tải lên: 08/03/2014, 22:20

... played by specific domains in the corresponding transcription factors during in vivo erythroid and megakaryocyte development. Erythroid Kruppel-like factor (EKLF) This zinc finger protein plays ... Whang- Peng,J.&Haynes,B.F.(1984)Conversionofastemcellleukemia from a T-lymphoid to a myeloid phenotype induced by the ade- nosine deaminase inhibitor 2¢-deoxycoformycin. Proc. Natl Acad....

Ngày tải lên: 08/03/2014, 22:20

... JA, Benbow U, Vincenti MP, Sporn MB, Brinck- erhoff CE: A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflamma- tory cytokines. Arthritis ... several genes including those for some MMPs. Indeed, when NF- κB is maintained in the cytoplasm by constitutive levels of IκB, reduced expression of MMP-1, MMP-3 and MMP-13 is observed...

Ngày tải lên: 09/08/2014, 03:24