... activating Zp, the promoter of BZLF1, leading expression of Z EBRA, and thereby stimulation of early lytic genes, DNA re plication, and late gene expression [9,15,16]. There are a number of interesting ... the studyandthestudywasapprovedbytheMedicalEthics Committee at the Medical College of QingdaoUniversity, China.DNAs used in this study were extracted from freshspecimens and cell lines by using the ... may alter the affinity of pro-tein with DNA, while mutation at position 316 maycontribute less to the change of the capacity of DNA binding, according to the results of Manet, E and collea-gue[10]....