Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
... Nonetheless, modulation in RNA levels without changes in copy number of a gene is an infrequent event in drug resistant Leishmania. The use of both L. infantum and L. major MTX resistant mutants validated ... one of the first and most widely used drugs for understanding drug- induced plasticity and resistance mechanisms [5-8]. While Leishmania is sensitive t...
Ngày tải lên: 14/08/2014, 20:22
Báo cáo y học: " Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis" ppsx
... per- formed, including urinary levels of nicotine and its deriv- ative cotinine, and serum levels of carboxyhemoglobin to verify reported levels of smoking. Collection of Airway Epithelial Cells All individuals ... fold increase in pirin expression to 10% CSE and a significant increase in apoptosis, thus paralleling the in vivo observation. Apoptosis and the Pathogenes...
Ngày tải lên: 12/08/2014, 15:20
Báo cáo y học: " Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization" pdf
... resistance (R L ) and dynamic compliance (C dyn ) by a computer (Buxco Electronics, Inc. NY). Baseline R L and C dyn values were established and after administration of saline, ACh was given intravenously ... mortality and inhibited the immunoglobulin, eosinophil and Th2 cytokines associ- ated with this model of fungal infection [35,36]. Th2 cytokine levels in the BAL fluid...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis" pot
... detectable in SSc Fib+ patients in contrast with SSc Fib- patients. Discussion The pathogenesis of SSc is extremely complex, and no single unifying hypothesis or pathogenetic mechanism can explain all the ... calumenin in BALF from SSc Fib+ patients could further promote the synthesis of pro-inflammatory cytokines, the influx of inflammatory cells, and fibrinogenesis, wh...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report" pps
... frequency of megakaryocyte involvement in CML patients and the concurrent thrombocytosis in our patient, we assu med that platelet dysfunction was a manifestation of CML and that the megakaryocytes ... reveals that in chronic myelogenous leukaemia (CML) following interferon-α therapy, normalization of megakaryocyte size is associated with the loss of bcr/abl translocat...
Ngày tải lên: 10/08/2014, 23:21
Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf
... saturated fat-induced TLR4 signaling pathway is a likely mechan- ism linking dietary fat with inflammation and insulin resistance associated with obesity and type-2 diabetes [9,10,15-21]. Conversely, loss ... themselves capable of triggering TLR4 signaling by trasducing pro- duction of proinflammatory markers in macrophages, adipocytes, and liver leading to insulin resista...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice" docx
... TF-diet-induced obesity, hyperglycemia, hyperinsulinemia, hypercholester- olemia, and hyperleptinemia. What is interesting in this study is that mice with loss of function mutation in TLR4 had gained ... saturated fat-induced TLR4 signaling pathway is a likely mechan- ism linking dietary fat with inflammation and insulin resistance associated with obesity and type-2...
Ngày tải lên: 11/08/2014, 06:22
Báo cáo y học: " Review of "Systems Biology in Practice" by Edda Klipp, Ralf Hertwig, Axel Kowald, Christoph Wierling and Hans Lehrach" docx
... three main facets of systems biology as it stands today (metab- olism, signal transduction and gene expression) , but it also includes brief surveys of the cell cycle and ageing, an interesting chapter ... descriptive list of currently-available internet databases and tools and modelling tools, assessing the advantages and disadvan- tages of each. Every concept and meth...
Ngày tải lên: 13/08/2014, 23:20
Báo cáo y học: " Correction of technical bias in clinical microarray data improves concordance with known biological information" pptx
... correction increases consistency of correlation with ER status within five clinical breast cancer studiesFigure 6 Bias correction increases consistency of correlation with ER status within five clinical ... that the dis- ruption of replicate pairs is an artifact caused by noise in the filtered-out genes. If this noise were entirely random, filtering out genes would be the only w...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo hóa học: " Reversal of TMS-induced motor twitch by training is associated with a reduction in excitability of the antagonist muscle" ppt
... the antagonist muscle at rest; (a) pre training and (b) immediately post training (t1), showing decreased amplitude following 5 minutes of training, associated with wrist movement, in direction ... repetition of the wrist, consistent with an early phase of learning, and involve release of activation to antagonist muscles. These findings may have implications for training p...
Ngày tải lên: 19/06/2014, 08:20