Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
... Nonetheless,modulation in RNA levels without changes in copy number of a gene is an infrequent event in drug resistant Leishmania. The use of both L. infantum and L. major MTX resistant mutants validated ... one of the first and most widely used drugsfor understanding drug- induced plasticity and resistancemechanisms [5-8]. While Leishmania is sensitive to MTX, the drug is not used clinically to ... Leishmania is distributed worldwide and is responsible for a wide spectrum of diseases, includingcutaneous, mucocutaneous and visceral leishmaniasis. Novaccines are presently available against...
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Báo cáo y học: " Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis" ppsx
... per-formed, including urinary levels of nicotine and its deriv-ative cotinine, and serum levels of carboxyhemoglobin toverify reported levels of smoking.Collection of Airway Epithelial CellsAll individuals ... fold increase in pirin expression to 10% CSE and a significant increase in apoptosis, thus paralleling the in vivo observation.Apoptosis and the Pathogenesis of Chronic BronchitisOne of the main ... originally noted pirin to be up-regulated in microar-rays of phenotypically normal individuals that smoke[24], a finding also made by Spira et al [37], in their study of genes up-regulated in...
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Báo cáo y học: " Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization" pdf
... resistance (RL) and dynamic compliance (Cdyn)by a computer (Buxco Electronics, Inc. NY). Baseline RL and Cdyn values were established and after administration of saline, ACh was given intravenously ... mortality and inhibited theimmunoglobulin, eosinophil and Th2 cytokines associ-ated with this model of fungal infection [35,36].Th2 cytokine levels in the BAL fluid of C57BL/6 mice were inhibited ... previ-ously described [12]. Briefly, anesthesia was provided byintra-peritoneal administration of a mixture of ketamine(100 mg/kg) and xylazine (20 mg/kg), every 20 minutesbefore and during all...
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Báo cáo y học: "Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis" pot
... detectable in SScFib+ patients in contrast with SScFib-patients.DiscussionThe pathogenesis of SSc is extremely complex, and no singleunifying hypothesis or pathogenetic mechanism can explain allthe ... calumenin in BALFfrom SScFib+ patients could further promote the synthesis of pro-inflammatory cytokines, the influx of inflammatory cells, and fibrinogenesis, whereas the downregulation of GSTP,Cu–Zn ... 2-DE and immunoblotting.MM was involved in data analysis and performed statisticalanalysis. CL and CV selected patients and revised all clinicalcharts. PE was involved in the coordination of...
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Báo cáo y học: " Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report" pps
... frequency of megakaryocyteinvolvement in CML patients and the concurrentthrombocytosis in our patient, we assu med that plateletdysfunction was a manifestation of CML and that themegakaryocytes ... reveals that in chronic myelogenousleukaemia (CML) following interferon-α therapy, normalization of megakaryocyte size is associated with the loss of bcr/abl translocation.Histopathology 31:215–221. ... Bergwelt-Baildon*AbstractIntroduction: In patients with chronic myeloid leukemia, tyrosine kinase inhibitors suppress the BCR-ABL+clone and often induce complete molecular remissions. Megakaryocytes in such patients...
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Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf
... saturatedfat-induced TLR4 signaling pathway is a likely mechan-ism linking dietary fat with inflammation and insulinresistance associated with obesity and type-2 diabetes[9,10,15-21]. Conversely, loss ... themselvescapable of triggering TLR4 signaling by trasducing pro-duction of proinflammatory markers in macrophages,adipocytes, and liver leading to insulin resistance. Insu-lin resistance is a main pathological ... blunting of TF diet-induced weight gain, hyperinsulinemina, and hyperglyce-miainmicewithlossoffunctionmutationinTLR4,our results in this study do not directly contradict thepreviously proposed...
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Báo cáo y học: "Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice" docx
... TF-diet-inducedobesity, hyperglycemia, hyperinsulinemia, hypercholester-olemia, and hyperleptinemia.What is interesting in this study is that mice with loss of function mutation in TLR4 had gained ... saturatedfat-induced TLR4 signaling pathway is a likely mechan-ism linking dietary fat with inflammation and insulinresistance associated with obesity and type-2 diabetes[9,10,15-21]. Conversely, loss ... blunting of TF diet-induced weight gain, hyperinsulinemina, and hyperglyce-miainmicewithlossoffunctionmutationinTLR4,our results in this study do not directly contradict thepreviously proposed...
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Báo cáo y học: " Review of "Systems Biology in Practice" by Edda Klipp, Ralf Hertwig, Axel Kowald, Christoph Wierling and Hans Lehrach" docx
... threemain facets of systems biology as it stands today (metab-olism, signal transduction and gene expression) , but italso includes brief surveys of the cell cycle and ageing, aninteresting chapter ... descriptivelist of currently-available internet databases and tools and modelling tools, assessing the advantages and disadvan-tages of each. Every concept and method introducedthroughout the book is ... results of single -gene studies) arebeing reinterpreted in a broader cellular context, radicallynew research strategies are appearing, novel insights intothe integration of cell systems are being...
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Báo cáo y học: " Correction of technical bias in clinical microarray data improves concordance with known biological information" pptx
... correction increases consistency of correlation with ER status within five clinical breast cancer studiesFigure 6Bias correction increases consistency of correlation with ER status within five clinical ... that the dis-ruption of replicate pairs is an artifact caused by noise in thefiltered-out genes. If this noise were entirely random, filteringout genes would be the only way to reduce noise. However, ... of interest, separating biasThe correlation between genes and bias metrics is non-randomly distributed according to mean gene intensityFigure 4The correlation between genes and bias metrics is...
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Báo cáo hóa học: " Reversal of TMS-induced motor twitch by training is associated with a reduction in excitability of the antagonist muscle" ppt
... the antagonist muscle at rest; (a) pre training and (b)immediately post training (t1), showing decreased amplitudefollowing 5 minutes of training, associated with wristmovement, in direction ... repetition of the wrist, consistent with an earlyphase of learning, and involve release of activation toantagonist muscles. These findings may have implicationsfor training paradigms in the neurorehabilitation ... by training is associated with a reductio n in excitability of theantagonist muscle. Journal of NeuroEngineering and Rehabilitation 20118:46.Submit your next manuscript to BioMed Centraland...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ