Báo cáo y học: "The transcriptional program underlying the physiology of clostridial sporulation" pptx

... increased the time to first exacerbation by 213 days. This benefit was not at the expense of increased therapy in the intervention group. In this study, the inflammatory phenotype of the exacerba- tions ... subphenotypes of airway disease based on the pattern of airway inflammation may be particularly useful in increasing our understanding of the disease. The use of...

Ngày tải lên: 08/08/2014, 21:20

... primary cultu re used to generate the cell line, and DNA from the cell line. Interestingly, 63 were confirmed a s mutations onlyinthecellline(Ti/Tv=1.1;onefailedassayinpri- mary culture). Of the ... homopolymer run of three or more bases, had a GC content of ≤ 60%, was a edit distance of at least four away from all other membersofthesetof96,andscreenednegativewhen compared with...

Ngày tải lên: 09/08/2014, 22:23

... should nearly always be in the homozygous state in mutant embryos, but they should also be present in the heterozygous state in two-thirds of the phenotypically wild-type embryos. Therefore, tags ... embryos, but they should nearly always be present in either the heterozygous or homozygous state in wild-type embryos. In contrast, tags that are highly linked to the mutant allele sh...

Ngày tải lên: 14/08/2014, 07:21

... microarray study to an earlier microar-ray study that examined the early sporulation of C. acetobutylicumComparison of the present microarray study to an earlier microar-ray study that examined the ... time, probably as a result of its depletion in the culture medium. Genes underlying the activation of the sporulation machinery and the genes for tryptophan and histidi...

Ngày tải lên: 14/08/2014, 20:22

... coordination of the study. MK determined the phenotype of polymorphisms. TS and YK participated in coordination of the study. JO, HK and MO were responsible for the recruitment and classification of patients ... evaluated the efficacy of the ET receptor antagonist bosentan in patients with PAH that was either primary or asso- ciated with SSc. Another therapeutic strategy...

Ngày tải lên: 09/08/2014, 08:22

... indicated by a spot, with the intensity of the spot representing the proportion of significantly differentially expressed transcripts for each one of the transcriptional modules. The color of the spot ... (HMFN0839)* 1-Acylglycerol-3-phosphate O-acyltransferase 9 [GenBank:NM_032717.3 ] 34 MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetra...

Ngày tải lên: 09/08/2014, 20:20

... Bristol-Myers Squibb Co. were the only individuals involved in the analysis of data and development of this manuscript. The greater funding body did not play a role in the analysis of data or ... inci- dence rates (IRs) of the specified outcomes, and the ability o f the investigators to complete the analyses for regulatory filings. Table 2 presents the characteri sti...

Ngày tải lên: 12/08/2014, 12:20

... variety of methods have isolated a growing number of HIV integrase-interacting host factors. Many of these factors have been identified by analyzing the components of the PIC and by yeast two- hybrid ... integration of the double-stranded DNA viral genome into the genome of their hosts. The viral integrase protein is key in this essential step of the retroviral life...

Ngày tải lên: 13/08/2014, 05:20

... is the processing of the RNA; both contribute to the level of RNA at the site of transcription at steady state [35]. It is however unlikely that detection was lowered by scarce accessibility of ... level of ECFP expression and to be highly inducible by GST-Tat by fluorescence microscopy. The number of integrations was assessed by southern blotting with a probe for ECFP a...

Ngày tải lên: 13/08/2014, 05:21

... considered other characterized TFs and putative, as yet uncharacterized regulators. We ana- lyzed the history of each of the global regulators, and of a sam- ple of each of the other types of regulators ... grows more rapidly than the size of the network. However, because only 13% of the TFs evolved by duplication within the E. coli lineage, and because the maj...

Ngày tải lên: 14/08/2014, 08:20