Báo cáo y học: "Identification of motifs that function in the splicing of non-canonical introns" doc
Báo cáo y học: "Identification of motifs that function in the splicing of non-canonical introns" doc
... C-rich motifs can
only partially compensate for G-rich motifs.
Strengthening the PY tract eliminates the role of the
C-rich motifs
We next investigated the role of the PY tract in LCAT intron 4
splicing. ... decrease in splicing does
suggest that the PY tract may be playing a role. Strengthening
the PY tract by mutating the sequence to include a run of ei...
Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... of a variety of
inflammatory chemokines and their receptors [5,6]. In vitro
studies have suggested that both so-called homeostatic
chemokines and inflammatory chemokines, including CC
chemokine ... on the available in vivo data, which
may provide more insight into the chances that disrupting
one single factor of the complicated chemokine network
could be clinically effecti...
Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... processes
underlying RP and PAH contribute to the familiar pattern of
skin, renal and gastrointestinal pathology. The emergence of
effective and conveniently administered therapy for PAH
increases the importance ... cell dysfunction is characterised by
decreased production of the vasodilators nitric oxide and
prostacyclin, and by enhanced release of endothelin-1.
Endothelial c...
Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... important in the proliferation of
RA FLSs in the pathogenesis of RA.
Introduction
Synovial tissue from healthy individuals consists of a single
layer of synovial cells without infiltration of inflammatory ... significantly impaired the SF-mediated proliferation
efficacy of FLSs (Figure 4b). These results suggest that the
GM-CSF in SF has a key role in the hyper...
Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... level of IGF-induced collagen II synthesis
after 11 days of cytokine treatment and no IGF-induced colla-
gen II synthesis after 17 days of cytokine treatment (Figure
2b).
Interestingly, under the ... type II synthesis, whereas proteoglycan synthesis was
strongly attenuated. In contrast, at the time of maximal aggre-
canase activity, the proteoglycan loss was fully reversible....
Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx
... quality
control program run by the Korean Society of Laboratory
Medicine [3]. In 1999 and 2007, reports of antinuclear
antibody test using the IT-1 cell line on 208 and 588
systemic lupus erythematosus (SLE) ... with
cDNA encoding human Ro60. A human macrophage cell line
called the IT-1 cell line was first introduced at the American
College of Rheumatology meeting held in Mi...
Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx
... systematic study is mandatory to compare the sensitivity
and specificity of the AIT test for the detection of anti-Rib-P
antibodies and other antibody specificities using a variety of
contemporary diagnostic ... assay, and
then used these sera to determine the positivity and staining
patterns in the AIT test. This method raises concerns
because it is generally known that i...
Báo cáo y học: "Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trial" ppt
... being exploratory and will not be the focus
of the resulting manuscript
Sample size
It is considered that a minimum clinically important
change in the Oxford Ankle Foot Questionnaire in any
domain ... for the first time. The outcomes of this trial are
therefore likely t o strongly influence practice guidelines
and clinical care in this area.
This trial will be limited by...
Báo cáo y học: "Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report" doc
... vascular
injury [6]. While certain drugs are known to cause spe-
cific types of injury, the type of injury in idiosyncratic
drug reactions can be of variable morphology. A liver
biopsy can be ... idiosyncratic hepatotoxicity.
The main treatment of drug-induced liver toxicity is
withdrawal of the offending agent. Most patients recover
completely; therefore, management involve...
Báo cáo y học: " Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study" ppsx
... stereotyped thinking, and poor attention items of the scale
Psychosis SCAP-HQ Bothered much by feeling that others are spying against you or plotting against you,
hearing voices that other people ... identified
(Table 2) in the first step of the analysis and labeled
from the “best” to “worst” cluster, with severity of symp-
toms and level of functioning influenc ing clus...