Báo cáo y học: "Evolutionary conservation of sequence and secondary structures in CRISPR repeats" pps

... this CRISPR function involves sampling and maintaining a record of invasive DNA ele- ments, and inhibition of gene functions necessary for inva- sion [12]. Indeed, it was recently shown that CRISPRs ... the stability of each secondary structure. We compared the stability of the pre- dicted secondary structure of repeats and spacers to that of similarly sized sequences...

Ngày tải lên: 14/08/2014, 20:22

... information Genome Biology 2007, 8:R132 pathway, implying increased flux of thiols from methionine to cysteine and GSH [51,55]. Possibly increased GSH production retards aging by supporting a range of mechanisms ... greater certainty the extent of evolutionary conservation of regulation of genes by IIS. For example, there may be differences in the degree of evolution- ary c...

Ngày tải lên: 14/08/2014, 07:22

... two types of interactions: inter- protein DDIs (interactions between domains in two different proteins) and intraprotein DDIs (interacting domains within multidomain proteins). The 3DID and iPfam ... number of interacting amino acids in A, the number of interacting amino acids in B, and the number of amino acid-amino acid interactions between the two domains. Two domains r...

Ngày tải lên: 14/08/2014, 17:22

... (Department of Dermatology, Venerology and Allergol- ogy, University Hospital Charité, Berlin, Germany), Kerstin Steinbrink (Department of Dermatology, University of Mainz, Germany), Annegret ... (Department of Internal Medicine, Uni- versity of Giessen, Germany), Adelheid Maria Müller and Rotraud Meyringer (Department of Internal Medicine, Univer- sity of Regensburg, German...

Ngày tải lên: 09/08/2014, 13:22

... using one of three types of bone staples, two types of memory staple (Memory staple and heat-activated Memoclip) or a standard stainless steel staple (Richards). Constructs were loaded in bending ... and trauma. This in turn leads to improved healing and reduced post-operative pain [2]. Various types of bone staples are available, differing in their shape and physical pr...

Ngày tải lên: 10/08/2014, 21:23

... Register of Criminality at follow-up in July 2007. The crimina l reg- ister has lifetime information about all criminal proceed- ings against everyone residing in Norway. The reported findings are ... description of the offences committed. The offences were classified into violent offences (all offences involving interpersonal aggression and threats, robbery, arson), sexual offences...

Ngày tải lên: 11/08/2014, 15:22

... report of a 44-year-old woman with acquired partial lipodystrophy. To obtain insight into the molecular basis of lipoatrophy in acquired partial lipodystrophy, we examined gene expression in adipose ... JCD performed the analysis and interpretation of mitochon- drial DNA data and JG and MG analyzed the mRNA. FV designed and coordinated the study and was responsible for fin...

Ngày tải lên: 11/08/2014, 21:22

... analyzed by using FlowJo software (Tree Star, Ashland, OR). ELISA and multiplex cytokine assay Plasma was separated from heparinized peripheral blood and stored in -80°C for later cytokine assays. ... Puisieux A, Eliaou JF, Bonnefoy-Berard N: Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythemat...

Ngày tải lên: 12/08/2014, 12:20

... ammatory cytokine production.  is chronic produc- tion of in ammatory cytokines and proteases may lead to thinning of the plaque wall and eventual rupture, which results in exposure of the ... telomere shortening/senescence and cytokines such as TNF [22-24]. Mechanisms of endothelial injury and atherosclerosis in SLE Induction of an imbalance of vascular damage...

Ngày tải lên: 12/08/2014, 15:22

... Meanwhile, inflammatory status induced by proinflammatory cyto- kines, includi ng tumor necrosis factor a,IL-1b, and IL- 6, also results in reduced bile flow via changing gene expression of transporte ... prognosis. The discrepancy between clearance of jaundice and prognosis could be partially explained by a small num- ber of cases. And, prognosis of native liver of BA is als...

Ngày tải lên: 13/08/2014, 13:20