Báo cáo sinh học: " AAV2-mediated in vivo immune gene therapy of solid tumours" potx

... ruling out an immune reaction to AAV prevent- ing expression of the immune genes. Furthermore, as indi- cated in Figure 4a, IM delivery of AAV2-Luc resulted in long-term gene expression indicating ... as: Collins et al.: AAV2-mediated in vivo immune gene therapy of solid tumours. Genetic Vaccines and Therapy 2010 8:8. Submit your next manuscript to BioMed Centr...

Ngày tải lên: 14/08/2014, 19:22

... being revealed in increasing detail. An interesting aspect of several of these studies is that they often choose to sequence the mitochondrial cytochrome oxidase gene (COI), sometimes in tandem with ... were glaciated in the Pleistocene. AAbbssttrraacctt Genetic studies of organisms based on coalescent modeling and paleoenvironmental data, including a new study in BMC Biology...

Ngày tải lên: 06/08/2014, 18:21

... phenotype. marker-assisted introgression / Merino sheep / sheep breeding 1. INTRODUCTION The process of introgression in the field of animal breeding describes the transfer of a favourable allele of a gene from ... candidates in the different parts and lines of the breeding structure are summarised in Table I. In Part 1, the breeding structure comprised two lines of sheep:...

Ngày tải lên: 14/08/2014, 13:22

... can have dramatic effects on binding affinities even if the sequence of the binding site is identical. Since the comparison of base pairing patterns is a crucial step in such investigations we provide ... energy and base pairing pattern of a pair of interacting RNA molecules. In contrast to earlier approaches, complex internal structures in both RNAs are fully taken into account...

Ngày tải lên: 12/08/2014, 17:20

... regs in cancer patients undergoing hTERT-pulsed DC vaccination. This novel finding is of substantial significance in hTERT-based immunotherapy in particular, and cancer immuno- therapy in general. Studies ... Schallenberg S, Enk AH: Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune func- tions in vivo and...

Ngày tải lên: 18/06/2014, 15:20

... constant flows of traditional donor financing may not allow substantial initial investment with lower rates of continuing finance. Recent innovation in donor funding may address both shortcomings. On ... monitoring or outsource enforcement to existing institutions); and evaluation (in order to broaden the evidence on the effectiveness of financial incentives in increasing the healt...

Ngày tải lên: 18/06/2014, 17:20

... changes in the dynamics of the labour market. According to this line of reasoning, the present trend towards greater flexibility of salaries and the length of the working day favours women's insertion into ... groups of permanent workers in the health districts to increase may result in lack of competence in respond- ing to job requirements. In general, workers loca...

Ngày tải lên: 18/06/2014, 17:20

... during residency. In recent years, the development of Academic Centers of General Medicine has given general medicine more visibility to candidates. A profound reform of the medical training ... also empha- sized the growing part of inactive doctors, 19% of all registered GPs in 2000 being inactive in the healthcare sector 5 years later (in 2005). The part of inactive GPs w...

Ngày tải lên: 18/06/2014, 17:20

... neuroserpin decrease. All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings. Endpoints The primary endpoint was the decrease of neuroserpin levels ... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome. T he influence of neuroserpin decrease at 24 h on serum levels of molecula...

Ngày tải lên: 18/06/2014, 19:20

... intra-cerebrally injected in newborn mice [37]. Using expression profiling, they identified markers of gliomagenesis, SULF2 appearing among the candidate cancer-causing genes. In addition to its ... rocesses, generating diversity of the chains and thus d iversity of binding. Such mechanisms are regulated by sulfotrans- ferases involved in the biosynthesis of HS. Another class o...

Ngày tải lên: 18/06/2014, 19:20