Báo cáo sinh học: "Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice" pptx
Báo cáo sinh học: "Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice" pptx
... paperTissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal miceChristina A Pacak†, Yoshihisa Sakai†, Bijoy ... muscle following systemic vector administration. Importantly, these promoters provide an added layer of control over transgene activity following systemic gene delivery. FindingsWhen developing gene ... rAAV2/9 -mediated gene delivery using the α-MHC promoter is effective for focal transgene expression in the heart and theDes promoter is highly suitable for achieving gene expression in cardiac...
- 5
- 214
- 0
Báo cáo sinh học: "Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance" ppt
... as aninsulin-binding protein [6]. Although the reportedbinding of IGFBP-7 to insulin awaits confirmation [7,8],it can compete with insulin for binding to the insulinreceptor (InR) and inhibit ... IGFBPs, possibly accounting for the affinity of IGFBP-7 for insulin [6]. Interestingly, Imp-L2 has beenshown to bind human insulin, IGF-I, IGF-II and proinsulin,and its homolog in the moth Spodoptera ... ooff IIIISSWe reasoned that the overexpression of a Dilp-bindingprotein that impinges on the ligand-receptor interactionshould counteract the effects of receptor overexpression.dInR overexpression...
- 11
- 345
- 0
báo cáo sinh học:" A strategy to improve skills in pharmaceutical supply management in East Africa: the regional technical " potx
... Malaria Ini-tiative have significantly increased availability and accessto medicines in some parts of the developing world. How-ever, these increases in the supply of medications arestraining ... medications inventories accurately. In addition, increased supply of medicines often meansincreased opportunity for inappropriate use [1-3]. Inap-propriate patterns of drug use behaviour can result in unsafe ... the skills of staff membersand to hire new staff demonstrates the long-term poten-tial of the model. Following the development of the training materials andthe training of a number of their...
- 6
- 366
- 0
báo cáo hóa học:" Tissue specific characteristics of cells isolated from human and rat tendons and ligaments" pptx
... Inter-estingly, in the Achilles cells, although there was a reduc-tion in the intensity of staining indicating a reduction in cell number, on analysis there was no significant reduc-tion in ... pattern of response was inconsistent in the other markers. In the rat,the intensity of expression of CD90 was also higher in thePT cells as compared to the Achilles and tail cells. Differ-ences in ... developments in tissue engineering, in particular of mesenchymal tis-sues, holds great promise for the treatment of chronic anddebilitating diseases. However, the source of cells for thegeneration of...
- 11
- 342
- 0
Báo cáo sinh học: " A reparameterization to improve numerical optimization in multivariate REML (co)variance component estimation" pdf
... estimation package. In: Proceedings of an ECSymposium on Application of Mixed Linear Models in the Prediction of Genetic Merit in Pigs (E Groeneveld, ed) (in press)Kovac ... number of illegal points prior to reparameterization. Accordingly, run 1finished in less than a 20th of the time converging to the best point, while run 2and 3 finished ... sampling-based procedures like DS(Dennis and Torczon, 1991)) fail increasingly as the dimensionality of the problemincreases. Thus, the problem of undefined parameters arising...
- 9
- 251
- 0
Báo cáo y học: "Tissue-specific spatial organization of genomes" docx
... proba-bility of containing the same number of chromosomes assum-ing a uniform random distribution of 40 sphericalchromosomes of excluding volume with a radius of 10% of thenuclear volume in a spherical ... visualized single chromo-somes by fluorescence in situ hybridization (FISH) usingchromosome -specific probes and analyzed their position in normal interphase cells containing a diploid complement of fluorescent ... The topological organi-zation of chromosomes 9 and 22 in cell nuclei has adeterminative role in the induction of t(9,22) translocationsand in the pathogenesis of t(9,22) leukemias. Chromosoma1999,...
- 9
- 215
- 0
Báo cáo sinh học: "The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression" docx
... levels of transgene expression. From our experience shown onthis study of using single-stranded rAAV2-TTR-RB15 vec-tor in mice, we knew it is necessary to generate an optimalvector to obtain successful ... asequence-nonspecific interferon response [29] and theinduction of gene activation of siRNA appears to be tran-sient. However, using synthetic 21 nucleotides targeted specific to gene Fas in mice ... Tangirala RK, Rubin EM, Palinski W: Quantitation of atheroscle-rosis in murine models: correlation between lesions in theaortic origin and in the entire aorta, and differences in theextent of lesions...
- 11
- 222
- 0
Báo cáo sinh học: "Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery" docx
... design of new delivery strategiesand biosafety.Integration into the host cell genome could produce inser-tional mutagenesis, which would have the potential of activating or inactivating genes. In ... its integrity [32]. In addition, theresults provided by Ledwith et al. (2000), using differentplasmid constructs suggest that the risk of integration of plasmid DNA vaccines following intramuscular ... for vaccination in a clinical setting. In addition, the results of long time biodistribution/doseafter intramuscular delivery were observed and describedfor the first time herein. Accordingly,...
- 10
- 243
- 0
Báo cáo sinh học: "Tissue distribution of DNA-Hsp65/TDM-loaded PLGA microspheres and uptake by phagocytic cells" docx
... involved in the uptake process, micereceived a single dose of an intramuscular injection of 6-coumarin labeled microspheres containing pcDNA3-Hsp65/TDM, pcDNA3/TDM (microspheres containing ... of theseimportant questions in more detail is required to assurethe biosafety of microspheres allowing the advance of thistechnology to a clinical setting against tuberculosis or in veterinary ... vaccines. In this study we first evaluated the dis-tribution of the PLGA microspheres containing DNA-Hsp65/TDM and then addressed the cells involved in theuptake process following the intramuscular...
- 8
- 296
- 0
Báo cáo sinh học: "Altering a-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism" docx
... higher transgene expression than FIV-WE54 in neonatal mice initially (1and 3 weeks post-injection) and subsequently d isplayedsimilar levels of expression for the remaining 13 weeks of observation ... administered in vivo are pre-sented in Table 1. The University of Iowa InstitutionalAnimal Care and Use Committee approved this study.Bioluminescence imaging Following FIV-Luc delivery, in ... expected. Incubating virus with increas-ing concentrations of BSA did not change transduction of any vector. The concentration of soluble a-DGrequired to produce a 50% reduction in binding (C50)forFIV-WE54...
- 13
- 218
- 0
Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘI