Báo cáo y học: "Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer''''''''s disease" pot

... epilepsy samples, 30% is explained by dif- ferences in brain tissue type, and an additional 11% is explained by differences between AD and control samples (combining main and interaction effects ... refereed research interactions information Open Access 2007Heinzenet al.Volume 8, Issue 3, Article R32 Research Alternative ion channel splicing in mesial temporal lobe ep...

Ngày tải lên: 14/08/2014, 18:20

... fluorescence in situ hybridization using cyanine and fluorescein dyes: ultra-rapid chromosome detection by directly fluorescently labeled alphoid DNA probes. Hum Genet 1996, 97:390-398. 47. Yurov YB, ... filtration, and 4) functionalized microparticles [112]. Increased surface affinity and high ionic solutions are helpful in binding DNA to glass fiber and silica, due to low electr...

Ngày tải lên: 10/08/2014, 05:21

... structural integrity. The immunological properties of the recombinant precursor and the natural napin were indistinguishable by immunoblotting and ELI- SA inhibition using polyclonal antisera and sera ... contrast, LMW-napins are mildly polymorphic, but they are barely produced in the seeds, purified with a very low yield and mostly contamin- ated with the HMW-napins. Recombinant pro...

Ngày tải lên: 24/03/2014, 00:21

... Four enzymes participate in the synthesis of riboflavin from GTP and ribulose 5-phos- phate: pyrimidine deaminase/pyrimidine reductase, riboflavin synthase, GTP cyclohydrolase II/3,4-dihydr- oxy-2-butanone ... Francesco, R.D. (1991) Structure, synthesis, and physical properties of covalently bound flavins and 6- and 8-hydroxyflavins. In Chemistry and Biochemistry of Flavoenzymes (M...

Ngày tải lên: 31/03/2014, 08:20

... implications of this novel finding. Background Homocysteine is a non-essential sulfur-containing amino acid derived from methionine by demethylation. Vita- mins B12 and B6 as well as folate play an ... Depression Inventory; EDSS, Extended Disability Status Scale; Hcy, plasma homocysteine; RR-MS, relapsing/remitting MS. Correlation graph between plasma homocysteine (Hcy) and Beck Depressi...

Ngày tải lên: 08/08/2014, 23:21

... activity In an exploratory analysis, we employed the 32-joint counts to calculate disease activity indices using the DAS28 and SDAI formulae and defined remission by the traditional DAS28 and SDAI ... classification into remission. Thus, by indices that employ the 28-JC, there is only a very small number of patients in remission who have joints involved that are not contained in...

Ngày tải lên: 09/08/2014, 10:20

... SNVs were homozygous in gDNA and yet heterozygous in cDNA, and the median coverage for these SNVs in gDNA was only 12×, compared to 28× for SNVs that matched for zygosity. It is likely that many of the ... directly evaluate the sensitivity and specificity of RNA- Seq in identifying coding variants, and to evaluate how key parameters such as the degree of coverage and the ex...

Ngày tải lên: 09/08/2014, 20:22

... example, by blocking target sites [34], or in trans, for example, by changing the secondary structure in the vicinity of the target site. In addition, a number of RNA-binding motifs have been linked ... allows variability in seed region binding, including non-canonical seed base pairing; incorporat- ing a wide range of m icroRNA::site duplex and contex- tual features; training with...

Ngày tải lên: 09/08/2014, 20:22

... response by the recovering immune system, exacerbated production of pro-inflammatory cytokines or a lack of immune regulation due to inability to produce regulatory cytokines remains to be determined. ... may directly kill these cells. Increased LPS-binding protein (LBP) may also increase the host response and potentiate injury. We hypothesize that the excessive pres- ence of LPS in HIV/T...

Ngày tải lên: 10/08/2014, 05:20

... antioxidant glutathione (GSH) plays a key role in detoxifying endogenous and exogenous oxidants and limits the oxidation of cysteine residues in many proteins, thereby regulating redox signaling [9,10]. The ... ("nitrosative stress"). In addition, our evaluation of potential dysregu- lation of inflammation within the alveolar space was restricted to quantification of infla...

Ngày tải lên: 10/08/2014, 05:21