Báo cáo y học: "Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase" potx

... start of the cluster, and between the end of the cluster and the end of the protein. We then took the minimum of these divided by the length of the protein to be the position. We computed the foldedness ... biology of each regulatory system. Indeed, it is perhaps surprising that the proximity of features of the primary amino acid sequence are predic...

Ngày tải lên: 14/08/2014, 17:22

... History and pervasiveness of degeneracy The origin: a physico-mathematical notion The first use of the term degeneracy in the scientific literature can be trac ed to the early days of quantum theory ... finally argue that these concepts should be con- sidered together under the perspective of a unitary hypothesis. The network approach The success of a new par...

Ngày tải lên: 13/08/2014, 16:20

... and a nalyzed the activities of the alter- native complement activation pathways [24]. Serum levels of C3, Factor B and D, hemolytic activity of the alternative pathway, and the inhibitors H and ... nervosa remains poorly understood. The present study was designed to evaluate the role of complement C3 levels, the extent of complement activation and of complem ent h...

Ngày tải lên: 09/08/2014, 01:21

... study, we explored the possibility of using recently identified MMP T-cell epitopes for immunotherapy in AA. First, we monitored T-cell responses to the MMP epitopes during the course of AA. In general, ... inhibits the response to the arthritogenic epitope via bystander suppression. Immunotherapy using agents that induce T-cell-mediated bystander suppression makes it unnece...

Ngày tải lên: 09/08/2014, 03:24

... Sedova 3 1 Laboratory of Cancer Cell Biology of the 1 st Faculty of Medicine, Charles University, Prague and the Institute of Physiology, Academy of Sciences, Prague, Czech Republic 2 Department of Medical ... family members rather than the functionality expressed by a single enzyme in an isolated biochemical framework. The members of the DASH family Initially, DPPIV a...

Ngày tải lên: 09/08/2014, 07:20

... develop OA sponta- neously; therefore, they can be used as a model of primary OA. In STR/ort mice, OA progresses relatively slowly. Therefore, we examined the final result of TGF-β and Smad7 overexpres- sion ... potentially target the mesenchymal stem cells that eventually form the osteophytes after TGF-β exposure. This could be an option when key play- ers of osteophyte for...

Ngày tải lên: 09/08/2014, 07:20

... study, performed the majority of the laboratory work and analysis, and drafted the manuscript. AJF participated in the design of the study and interpretation of data. JAH conceived the study, ... factors [15]. Our data indicate that the senescent phenotype is linked to the increased production of degradation enzymes which may be brought about by the catabolic cyt...

Ngày tải lên: 09/08/2014, 10:20

... properly cited. Abstract Introduction The purpose of this study was to quantitatively evaluate the contribution of synovial lymphoid aggregates to autoantibody (rheumatoid factor [RF] and anti-cyclic ... syno- vial autoantibody production. The local synthesis of immunoglobulins and autoantibodies by rheumatoid synovium is well appreciated but its contribution to the circul...

Ngày tải lên: 09/08/2014, 13:21

... found to better predict retention of TNF inhibitors. The potential bias that these patients were likely to be more refractory can be adjusted for in part, but it is difficult to allow for the clinical ‘gut’ ... ineffectiveness of the drug) can inform the analysis. In contrast to stratification, this is an effective way to incorporate observations on all patient...

Ngày tải lên: 09/08/2014, 14:20

... (combination of lymphocytosis and granulocytosis). Bioplex analysis Cytokine concentrations adjusted according to the recovery rate of BALFs were determined by using the Bio-Plex Protein Array System (Bio-Rad, ... immunosuppressive therapies. Another limi- tation of the study is the low number of patients and the heter- ogeneity of the control group. In conclusion, we...

Ngày tải lên: 09/08/2014, 14:22