Báo cáo y học: "Decoding dosage compensation" ppsx

... early mouse embryos and in marsupials, the paternal X chromosome is always inactivated. In this type of imprinted dosage regulation the paternal X chromosome may be originally identified by its unpaired ... chromosome within a specific nuclear compartment may also play a role for its identification, but all these hypotheses ultimately hinge on the ability to distinguish the DNA of the X chr...

Ngày tải lên: 14/08/2014, 17:22

... Bergen, Norway. † Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden. ‡ Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA. Correspondence: ... inviable hybrids and reproductive isolation by Dobzhansky-Muller incompatibility [12]. Such a proposition is consistent with the loss of proteins not under dosage- balance constraint...

Ngày tải lên: 14/08/2014, 07:21

... the hyperactive X. This occurs at least in part through acetylation of histone H4 lysine 16 of the X chromosome, and this acetylation is believed to be cat- alyzed by the MOF histone acetyltransferase ... even if they do not contain one of the reported entry sites, attract the DCC when translocated into an autosome. This strongly argues that the reported entry sites are not strictly required...

Ngày tải lên: 14/08/2014, 14:21

... vibra- tory urticaria are very rare. In physical urticaria the routine diagnosis is mainly limited to identify the subtype by appropriate standardized challenge tests [68]. The association of physical ... serology for streptococci (antist- reptolysin, antiDNase B), staphylococci (antistaphy- lolysin), yersinia (IgA, IgG, immunoblot). If an infection is identified, it should be appropriately t...

Ngày tải lên: 08/08/2014, 21:20

... ENPP1 variants should be genotyped in patients with severe disease at the hip, knee, or spine. The osteoarthritis research community is relatively fortunate in that many groups have collected OA ... OA cohorts suitable for genetic analyses [6], making confirmatory studies feasible. The genetic investigation of osteoarthritis has had a fillip in recent years, with compelling associations ... r...

Ngày tải lên: 09/08/2014, 07:20

... S. pyogenes infection [2]. One consequence of the cytokine storm induced by superantigens may be to disrupt the development of antibody-mediated immunity. By switching off superantigenicity, the ... synthesized by Staphylococcus aureus and Streptococcus pyogenes, which share the immunological property of being super- antigens. Superantigens are characterized by the ability to bypass normal .....

Ngày tải lên: 12/08/2014, 18:20

... and colleagues examined the dynamics of DNA methylation as mouse embryonic stem cells (ES cells) progress to neural precursors and neurons in vitro. Intriguingly, very little change was found in ... methylation between pluripotent cells and their differentiated derivatives. The alterations observed occurred primarily at CpG-poor promoters, which under- went dynamic methylation and demethylati...

Ngày tải lên: 14/08/2014, 08:21

... liver, kidney, heart, astrocyte cell lines heart, testis, liver, kidney, lung, muscle, and lung and muscle Technique used Affymetrix microarrays Affymetrix microarrays Custom cDNA array RT-PCR Number ... http://genomebiology.com/2004/5/10/244 © 2004 BioMed Central Ltd The gene -dosage hypothesis for Down syndrome The Down syndrome (trisomy 21) phenotype is characterized by abnormalities a...

Ngày tải lên: 14/08/2014, 14:21

... not have xyloglucan endotransgly- cosylase (XET) activity and that XET lacks wall extension activity, either by itself or in the presence of xyloglucan oligosaccharides. 68. Yuan S, Wu Y, Cosgrove ... http://genomebiology.com/2005/6/12/242 Genome Biology 2005, 6:242 Expansins do not have hydrolytic activity or any of the other enzymatic activities yet assayed [64,66,67]. A report that they...

Ngày tải lên: 14/08/2014, 15:20

... University, Cambridge, USA) brought aspects of protein expression, abundance and stability into focus in her talk on yeast physiology, which included an impressive systematic analysis of extremely large ... antifreeze agents - as used by many animals to prevent freezing in winter. Hochstrasser noted that to simplify handling, protein samples can be digested by trypsin immediately after sampli...

Ngày tải lên: 14/08/2014, 15:20