Báo cáo y học: "umping the shark" pps
... the Marlon Brando character in the movie &apos ;The Wild One'. For those of you not old enough to remember the thin, pre-Godfather Brando, virtually the same charac- ter type appears as the ... male lead in the musical 'Grease' (in the film of which, the part is played by John Travolta). 'Happy Days' ran for 11 years, far longer than its rather silly...
Ngày tải lên: 14/08/2014, 17:22
... AT-islands has led to the emergence of a new class of drugs that specifically alkylate them [67]. These drugs exhibit an extraordinary cytotoxicity, which is likely to be due to their disruption of ... gene, the Chinese hamster dihydrofolate reductase β and β’ genes, the human β-globin gene, the chicken α-globin and lysozyme genes, and the Xenopus and mouse c-myc genes, function as...
Ngày tải lên: 14/08/2014, 08:20
... contrary to widespread opinion, collaboration between industry and academia in proteomics is indeed fea- sible, despite the heterogeneity of the technology used and the complexity of the science. There ... to type-specific subpro- teomes such as the phosphoproteome (phosphorylated pro- teins), the glycoproteome (glycoproteins), the secretome (secreted proteins) and others. Antib...
Ngày tải lên: 14/08/2014, 15:20
Báo cáo y học: "To the Editor: We have diagnosed a patient from Quebec" ppsx
... rare frequency in the par ent popula tion may then have a higher fre- quenc y in the ne w population simply because one or mor e of the founders happened to carry the rare allele. If the new population ... or whether the Japanese mutation arose indepen- dently. In summary, this case illustrates the typical clinical manifestations of hyper-IgM syndrome due to AID deficiency, wh...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "Correction: The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties" ppsx
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis" ppsx
... with the anti-inflammatory cytokine IL-10. They showed the accumulation of this fusion protein at the site of inflammation, good therapeutic efficacy and a safety profile that provides the basis ... signaling? Unfortunately, they did not include in their studies the therapeutic impact of the targeting antibody alone, without Editorial Immunocytokines: the long awaited therapeuti...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Defining the chromatin signature of inducible genes in T cells" pps
... and the data are plotted for the different gene groups. The basal expression levels of the genes are from a matching human CD4+ lymphocyte microarray analysis [GEO:GSE10437]. The bar marks the ... the underlying histone density can vary across the genome, especially at promoter regions, the H3K9 acetylation values were also calculated rel- ative to the total histone H3 sc...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo y học: " Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging" pps
... many subnetworks were identified in only one study; this can be partially accounted for by noise in the individual microarray studies, the fact that the two studies used different microarray plat- forms ... identify the subnetworks that play a role in worm aging, and then explore their connection with known longevity genes. Finally, we apply them to assign putative aging-related funct...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: "When the pie is too small" pps
... is exactly the sum that BP has been forced to pay by the US government as a penalty for the Gulf of Mexico oil spill. I don’t know whether to laugh at that coincidence or just cry. Published: ... some of the pie-hogging big science programs and put the savings into the R01 pool. at’s what we should in fact do, so I guess there really isn’t a hope in hell that we will. By th...
Ngày tải lên: 09/08/2014, 20:22