Báo cáo y học: "Multiple independent evolutionary solutions to core histone gene regulation" potx

... regulation of core histone genes, little is known about the evolutionary dynamics that have given rise to these regulatory mecha- nisms. We present here an evolutionary analysis of core his- tone gene ... experimentally verified core histone cis-regulatory elements among 24 crown group eukaryotes. The evolution of core histone gene cis-regulatory sites and transcriptio...

Ngày tải lên: 14/08/2014, 17:22

... dominant L90 viruses and to the L90M viruses which later came to dominate the plasma quasis- pecies [9,13,30]. Using Bayesian evolutionary analysis to sample alternative phylogenetic trees we determined ... and the generic gag-pro and L90M specific PCR products, when generated from these samples, were also directly sequenced. Bayesian analysis for monophyletic origin of L90M carrying...

Ngày tải lên: 13/08/2014, 06:20

... P 2Y receptors may interact with another P 2Y sub- type, or with a non-P 2Y receptor, to form a dimer with novel pharmacological properties. Indeed, the P 2Y 1 and P 2Y 2 receptors both appear to ... regional variation in the P 2Y subtype distribution. Thus, multiple subtypes of P 2Y receptor are widely expressed in pulmonary artery smooth muscle and are likely to play a role i...

Ngày tải lên: 12/08/2014, 18:20

... coagulopathy, suffi cient activators seem to be present. Because of the question of activators, the authors see fi brinogen administration as adjunctive therapy to be used concomitantly with replacement ... KM, Tonnesen E, Ingerslev J, Sorensen B: Fibrinogen substitution improves whole blood clot  rmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical c...

Ngày tải lên: 13/08/2014, 20:22

... Saccharomyces cerevisiae, Schizosaccharomyces pombe, Staphylococcus aureus, Streptococcus pyogenes, Sulfolobus solfataricus, Synechocystis sp. PCC6803, Thermoplasma acidophilum, Thermotoga maritima, ... chicken is mainly due to strand-symmetric directional mutation pressures: dGTP-oxidation and symmetric cyto- sine-deamination hypotheses. Gene 2002, 300:141-154. 8. Singer GAC, Hickey DA:...

Ngày tải lên: 14/08/2014, 14:21

... prenatal and early postnatal development may affect gene expression, and subsequently the phenotype, through epigenetic gene regulatory mecha- nisms. Nutrition is important in providing methyl donors ... in humans, on cell-cycle progression by flow cytometry. Genes controlling several cellular processes were identified, includ- ing cell size, cytokinesis, apoptosis and phases of the cell...

Ngày tải lên: 14/08/2014, 17:22

... photoreceptor with similarity to photoactive yellow protein and plant phytochromes. Science 285, 406–409. 14. Davis, S.J., Vener, A.V. & Vierstra, R.D. (1999) Bacter- iophytochromes: Phytochrome-like ... CphB into a ÔnormalÕ cyanobacterial phytochrome. The loss of the phytochrome-like absorbance during affinity chromatogra- phy of the CphB/PCB complex, taken together with the absolute st...

Ngày tải lên: 08/03/2014, 23:20

... and Rheumatology, Georg-August-University, Göttingen, Germany 4 Center of Anatomy, Georg-August-University, Göttingen, Germany 5 Clinic of Orthopedic Surgery, Otto-von-Guericke-University, Magdeburg, ... Rheumatology, Otto-von-Guericke University, Magdeburg, Germany 2 Center of Experimental Rheumatology, Department of Rheumatology, University Hospital, Zurich, Switzerland 3 Division of Nephro...

Ngày tải lên: 09/08/2014, 01:21

... CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003, 423: 506-511. 90. Barton ... costimulatory signals and the presence of negative costimulatory signals. CD28 and cytotoxic T lymphocyte antigen-4 (CTLA-4; CD152), two homologous members of the immunoglobulin superfam...

Ngày tải lên: 09/08/2014, 01:23

... Carrington JC: Evolution of microRNA genes by inverted duplication of target gene sequences in Arabidopsis thaliana. Nat Genet 2004, 36:1282-1290. 45. Addo-Quaye C, Snyder JA, Park YB, Li YF, Sunkar ... closely related functions. For example, miR775.2targetstwogenesin the glycosyl hydrolase family. Different miRNA-like RNAs from the same miRNA precurso r may have tar- getsinthesamegenefamil...

Ngày tải lên: 09/08/2014, 20:22