Báo cáo y học: "Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism" potx

... 7, Issue 11, Article R109 Research Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism Florian M Freimoser * , ... properly cited. Polyphosphate metabolism in yeast& lt;p>A systematic analysis of polyphosphate levels in yeast knockout strains for almost every non-e...

Ngày tải lên: 14/08/2014, 17:22

... high-quality data relating to drug targets in yeast. We collected two high-quality training sets: an expert-curated set of 83 yeast protein-compound interactions, and yeast homologs of 180 human ... resource for systems biology. In the haploinsuffi- ciency profiling (HIP) assay consisting of all 6,000 heterozygous deletions (where one copy of each gene is deleted), most strai...

Ngày tải lên: 09/08/2014, 20:21

... usage, including disease-modifying agents and steroids, and laboratory testing, including rheuma- toid factor (RF) and C-reactive protein (CRP), of the nine RA patients are shown in Table 1. None of ... cells may be where the pathogenesis of RA originates, making the study o f their abnormal regulatory networks very important. In this study, we identify aberrant regulatory network...

Ngày tải lên: 12/08/2014, 17:21

... Thiery JP, Radvanyi F: Inhibition of human bladder tumour cell growth by fibroblast growth factor receptor 2b is independent of its kinase activity. Involvement of the carboxy-terminal region of ... involved in DNA mismatch repair Genetic instability caused by loss of MSH3 in cancers [44] PCGF2 Polycomb group ring finger 2, involved in protein-protein interaction and transcrip...

Ngày tải lên: 09/08/2014, 22:23

... are not in upstream regions but may be physiologically relevant. It may be that there are as yet undiscovered non-coding RNAs present near these binding sites, or that binding within coding regions ... labeled with Cy5 and Cy3 respectively, pooled and hybridized to a custom D. vulgaris tiling array to determine enriched gene targets (Figure 1A). In our study all RRs being examined pr...

Ngày tải lên: 09/08/2014, 23:20

... and likely relate to some of the underlying etiology or pathophysiology of psychiatric disorders. With two exceptions, each of the studies mentioned above has used a unique combination of ingredients. OneexceptionistheworkofSheaandcolleagues[7,8] whohavereportedmorethanonestudyusingasingle Simpson ... person-days) for 231 young offenders receiving a formula with 25 vitamins and mi...

Ngày tải lên: 11/08/2014, 15:22

... sensitivity analysis of the within-subjects analyses using data collected after all participating clinicians had received extensive training in GAF scoring (i.e. after July 2007) yielded very similar results. ... work- ers). In a sensitivity analysis of the BPRS within-patients analyses, in which only the first five years after baseline were included, there was no longer an associat...

Ngày tải lên: 11/08/2014, 16:22

... trials with adults. Beyond the issues of indistinguishability, equivalence and clinical effect, a very serious issue is the lack of deter mination of the level of blinding in the vast major- ity of ... majority of trials do not report on post- intervention blinding. The effect of unmasking of control subjects makes the interpretation of the existing clinical trials chall...

Ngày tải lên: 13/08/2014, 15:21

... pre- viously detected in NB4 cells using genomic tiling arrays. It is thus likely that many (and possibly the majority) of known genes are expressed and spliced in human tissues and cell lines, and ... for 16 novel isoforms. We also analyzed expression of two gene loci, namely SYN3 and TIMP3, in cells in which their expression was not detected by tiling microarray analysis. SY...

Ngày tải lên: 14/08/2014, 08:20

... 7% of children and youth aged 6-19 years participate in at least 60 minutes of moderate- to vigorous-intensity physical activity per day, thus meeting the current physical activity guidelines ... focusing on the relationship between overweight and obesity and time spent watching TV (Table 3). Body composition was measured in a variety of ways including b ody mass index (BMI), sum o...

Ngày tải lên: 14/08/2014, 08:20