Báo cáo y học: "Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways" doc

... necessary because of the immaturity of the current set annotations and the complexity of the underlying biology, and refinement of many of the sets will be required. Second, systematic examination of ... KS, and Z score metrics, and the divergence of the PCA and hypergeometric metrics from the others. It is also clear from these examples and other...

Ngày tải lên: 14/08/2014, 17:22

... follows. Let there be r indirect paths from X h to dN(t), and denote these by P 1 ,P 2 , ,P r . Let the indirect path P i be of the form: where w i is the length of the path. The strength of the indirect effect ... genes and feedback loops [25-29]. Activation of these pathways collectively promotes tumor growth and progression, although expression of the...

Ngày tải lên: 14/08/2014, 08:20

... beginning shortly after the start of VNS therapy and continuing through her pregnancy and delivery. 0 20 40 60 80 100 120 Date of Assessment Score: GAF Initiation of VNS Therapy Pregnancy 1999 2000 ... limited on the effects of VNS therapy during pregnancy, no safety issues were known that would affect the pregnancy. The patient decided to continue receiving VNS therapy...

Ngày tải lên: 08/08/2014, 21:20

... molecular dynamics, that offer the possibi- lity of analyzing the potential effect of the phosphorylation and de-phosphorylation process of each residue in the glo- bal structure and behaviour of the ... In the present work, the molecular dynamics analysis of the phosphoryla- tion of Ser-48 in HuR homodimmer offered a suitable hypothesis of how the phosphor...

Ngày tải lên: 10/08/2014, 09:22

... implementation research can help them understand the tradeoffs and uncertainty involved as they consider ways to roll out new programs. Since only a minority of new programs being implemented in the VA and elsewhere ... to the daily decisions of our key stakeholders. While research cannot be responsive to every need of managers and policymakers, we need to understand their p...

Ngày tải lên: 11/08/2014, 05:21

... motility. There are three general conditions that we know of that contribute to the selection of the mesenchymal or amoeboid mode: MMP activity levels; rigidity of the substratum; and level of integrin ... in controlling many cellular properties, including morpho- genesis, cell motility and the organization of the cyto- skeleton. The activity of these small GTPases...

Ngày tải lên: 14/08/2014, 21:20

... (1969) The genetic aspect of the familial amyloidotic polyneuropa- thy. Portuguese type of paramyloidosis. Humangenetik 7, 163–175. 3 Ando Y, Araki S & Ando M (1993) Transthyretin and familial ... hydrophobic residues in this region that are normally buried on the inside of the protein [98]. Dis- location of the C and D strands from their native edge region may re...

Ngày tải lên: 07/03/2014, 10:20

... Furuse and Hashimoto Annals of General Psychiatry 2010, 9:18 http://www.annals-general-psychiatry.com/content/9/1/18 Page 2 of 4 Given the important role of sigma-1 receptors in the regulation of ... 55 year old (traumatic subarachnoid hemorrhage and brain contusion), a 76 year old (sepsis by pyelonephritis), an 85 year old (cerebral infarction), and an 86 year old (pulmon...

Ngày tải lên: 08/08/2014, 23:21

... hypnotics. Therefore, we cannot exclude a possible contribution of these hypnotics on the efficacy of fluvoxamine for delirium. A further study of fluvoxamine alone will be necessary. Delirium is theorised ... in the mechanism underlying the beneficial effects of fluvoxam- ine against the postoperative delirium of these patients. In order to confirm the role of sigma-1 r...

Ngày tải lên: 08/08/2014, 23:21

... for the Celecoxib Rofecoxib Efficacy and Safety in Comorbidities Evaluation Trial (CRESCENT) Investigators: The effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy ... supported in part by the Oxford Pain Research Trust. Neither the Trust nor Merck Research Laboratories had any role in the design, planning or execution of the study, or in wr...

Ngày tải lên: 09/08/2014, 10:23