Báo cáo y học: "Arrestins: ubiquitous regulators of cellular signaling pathways" pdf

... arrestin subtype) regulators of G-protein-coupled receptors (GPCRs), the largest known family of signaling proteins. Arrestins bind to the cytoplasmic side of active phosphorylated forms of their cognate ... probably appeared early in the evolution of eukaryotes, before the separation of animals, plants and fungi. Yeast and several other species of fungi have related protein...

Ngày tải lên: 14/08/2014, 17:22

... patients with systemic sclerosis. Rheumatology 2001, 40:406-409. 68. Henry PA, Atamas, SP, Yurovsky VV, Luzina I, Wigley F, White B: Diversity and plasticity of the anti-DNA topoisomerase I autoantibody response ... the use of tissue sections of murine liver or kidney [10]. ANA can also be measured by enzyme-linked immunosorbent assay (ELISA), a much less cumbersome technique now employ...

Ngày tải lên: 09/08/2014, 01:21

... SLE. Methodology of the analysis of MAPK and NF- κκ B activation by multiparameter intracellular flow cytometry Analysis of MAPK phosphorylation To validate flow cytometric analysis of MAPKs in ... MAPKs Intracellular flow cytometric assays have been developed to assay general phosphorylation of tyrosine (pTyr) as well as to analyze specific amino acid phosphorylation of STATs (ty...

Ngày tải lên: 09/08/2014, 01:23

... utility of the GSG features did not depend heavily of the number of GSGs used, as GSGs of order >5 consistently Table 1 Features used in this study Feature group Characteristic Number of features ... analysis (SGA) [5,6] and dSLAM (heterozygote diploid-based synthetic lethality analy- sis with microarrays) [7,8], have made it possible to screen for negative GIs, namely synthetic...

Ngày tải lên: 09/08/2014, 20:21

... Virtual Difficult Airway Cart – http://anes-som.ucsd.edu/Airway/index.html This site allows visitors to explore a difficult airway cart as they are prepared at the University of California at San ... the American Society of Anesthesiologists presenting the evidence (or lack thereof) and recommendations for different airway management options. Sponsors The GASNet airway tutorial was spons...

Ngày tải lên: 12/08/2014, 20:20

... may mask cer- tain Nef phenotypes. For example, the presence of endo- toxin in some serum preparations may alter the cytokine profile of PBMC. In summary, using freshly isolated rather than cry ... pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity. J Biol Chem 2006, 281(28):19618-19630. 34. Wei BL, Arora VK, Raney...

Ngày tải lên: 13/08/2014, 01:21

... antibodies against cyclin E co-immunoprecipitated only the phosphorylated form of RNAP II from HTLV-I infected cells. Thus, if only indirectly, Tax may increase kinase activity resulting in enhanced ... site specific phosphorylation of the CTD is modified to allow for sequestration of splicing machinery and elongation factors, and release of the cap- ping machinery. Assembly of SWI/...

Ngày tải lên: 13/08/2014, 13:20

... YER190W YEL076WC UTR2 ATR1 HAP4 YOR315W YAP6 SOK2 PDR12 SWI4 RPI1 MSN4 ECM13 CUP9 YIL056W SGA1 YBL029W CLB1 YFR006W YBL113C YPR203W YBL112C YHL049C YML133C YJL225C YER045C YNL339C YLR465C YLR467W YLR463C COX9 QCR2 YJR078W YGR296W YDR545W YPL283C YLR466W NCE102 RPL19B YNR067C YPS4 AAP1 YEL045C YJL217W YEL047C CSI2 EXG1 MNN1 YDR451C YGR086C ERG6 HSC82 PCL7 CCP1, ... YFL027C FUS3 SST2 WSC3 PTR2...

Ngày tải lên: 14/08/2014, 14:21

... polymerization cycles, which corre- sponds to the optimal number during array synthesis. The number of polymerization cycles required to generate oligos on arrays is proportional to complexity, ... similar software We developed a suite of publicly available 5C computer pro- grams to promote mapping of functional interaction net- works in any non-specialized molecular biology laboratory....

Ngày tải lên: 14/08/2014, 21:20

... previously known to be involved in cellular signaling and the discovery of new phos- phorylation sites in known signaling proteins. As enzymatic catalysis by protein kinases is the only known physiological mechanism ... number of protein kinases phospho- rylate many synaptic proteins and that each synaptic phos- phoprotein is phosphorylated by many kinases [35]. This analysis allowe...

Ngày tải lên: 14/08/2014, 14:22