... Yoshimoto Y, Tanaka M,Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto H, Iino S, Taniguchi N, Maruyama I: The N-terminaldomain of thrombomodulin sequesters high-mobility group-B1 ... elic-iting an inflammatory response via the activation of theMitogen-activated protein kinases. Finally, the generation of C5b by cleavage of C5 generates the membrane attack com-plex that can lyse ... (HMGB1).These alarmins are endogenous molecules capable of activat-ing innate immune responses as a signal of tissue damage andcell injury. Among the alarmins, HMGB1 is a DNA nuclearbinding protein that...