Báo cáo y học: " Advances in the genetics and epigenetics of gene regulation and human disease" pps

... Further evaluation of the effect of genetic variation in MMP3 on the level of joint damage in RA is therefore required. The increasing comprehension of the role of genetics in disease outcome in ... Additionally, erosions often initially present in the small joints of the feet, and appear in the small joints of the hands at a later point in the...

Ngày tải lên: 09/08/2014, 10:23

... asso- ciated with the cyclin/cyclin-dependent kinase pathway was identified. The combination of RNAi and gene- expression profiling pro- vides further insight into gene function and the regulatory networks ... Using flow cytometry, Björklund and col- leagues analyzed the RNAi-induced loss -of- function of 70% of the genes in Drosophila, including those conserved in...

Ngày tải lên: 14/08/2014, 17:22

... technology has been, theoretically, to increase the safety and com- pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health ... with their free hand while maintain- ing the view of the operative field. This paradigm shift, in the form of endoscopic sinus surgery, began in North America in...

Ngày tải lên: 08/08/2014, 20:23

... enzymes involved in the detoxification of a broad range of toxic compounds and carcinogens, including dioxin [48]. Two of the most studied SNPs in detoxification enzymes are in the GST genes ... in discovering the genetic basis of endo- metriosis are early detection and improved treatment of endometriosis-associated symptoms, including infertility and pelvic p...

Ngày tải lên: 11/08/2014, 12:21

... therapeutic strategy. They can inhibit the activity and production of MMPs (MMP-1, MMP-3 and MMP-13, and MMP-2 and MMP-9). This family of agents includes tetracycline, doxycycline, minocycline and the tetracycline ... tightly attached to the matrix by binding to proteoglycans [24]. Adamalysins ADAM The adamalysin family includes the adamalysins (ADAM [a disintegrin an...

Ngày tải lên: 09/08/2014, 10:21

... activity thereby inhibiting the antiviral effects of interferon alpha which ultimately leads to viral persistence. This binding is because of the similarity of this PePHD d omain with phosphorylation ... always succeed in eliminating the virus completely from patient’s body. One of the mechanisms by which virus evades the antiviral effect of interferon alpha involves pro...

Ngày tải lên: 11/08/2014, 21:21

... ring of the sugars into the binding sites of the lectin. The posit ions of mannose observed in the GNA/ Man complex were used as starting positions to anchor mannose in the carbohydrate-binding ... explained by the profound shift in glycan recognition and the disappearance of carbohydrate-binding sites in GNA maize that have high affinity for mannose oligomer...

Ngày tải lên: 13/08/2014, 01:20

... S, Murley D, Toft E: Oxygenation within the first 120 h following coronary artery bypass grafting. Influence of systemic hypothermia (32 degrees C) or normothermia (36 degrees C) during the cardi- opulmonary ... modelling, data analysis and technical interpretation of the results, including statistical anal- ysis. DSK and SER drafted the manuscript, with all other authors bein...

Ngày tải lên: 13/08/2014, 08:21

Ngày tải lên: 13/08/2014, 11:22

... TNFα and IL-6 by macrophages and other cell types [99,100]. Therefore, one of the functions of MAP kinase signaling pathway may be to regulate the levels of cytokines or interleukines, thereby controlling ... kinase-1 and integrin-linked kinase are target genes of PPARβ. The up- regulation of these genes together with the down-regula- tion of PTEN led to an increas...

Ngày tải lên: 13/08/2014, 13:20