Báo cáo y học: "Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi" pdf

... 7:231 Genome Biology 2006, 7:231 comment reviews reports deposited research interactions information refereed research Minireview Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi ... mediated by short hairpin RNAs and microRNAs. RNA 2005, 11:220-226. 38. Cao W, Hunter R, Strnatka D, McQueen CA, Erickson RP: DNA constructs designed to produce...

Ngày tải lên: 14/08/2014, 17:22

... are convincingly replicated in independent cohorts. Moreover, although a recent twin study indicated that genetic factors play a role in determining the severity of RA [46], the heritability of ... and cartilage in RA is mediated by proteolytic enzymes that belong to the family of matrix metalloproteinases (MMPs). The most intensively studied proteinases are MMP3 (stromelysin) and MMP1...

Ngày tải lên: 09/08/2014, 10:23

... their trauma insult, after sustaining minor to moderate injuries. Our study supports this theory, dem- onstrating irrespective of age after sustaining a severe trauma insult the majority who die ... authors hypothesise the observed discrepancy may relate to PMC, which were not analysed in their study. Our study supports this theory identifying those patients with PMC being at an increase .....

Ngày tải lên: 13/08/2014, 23:21

... USA. 7 Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia. 8 Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge, CB3 0ES, UK. 9 Institute ... lactation-mediated inhibition, and in the second half of the year by photoperiod-me diated inhibi- tion that is removed as day length decreases [14]. The anatomy, physiology, e mbryology,...

Ngày tải lên: 09/08/2014, 23:20

... attack, characterized by a predominantly lymphocytic infiltration around the IVD in the early phase of the spondylitis [7-9], is most likely elicited by cross-recognition of IVD PG in mice immunized ... protein that regulates early TCR- initiated signaling in Th2 lineage cells. Immunity 2003, 18:403-414. 56. Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F: DEF6, a novel PH- DH-like dom...

Ngày tải lên: 09/08/2014, 01:22

... natu- rally in mice and humans and can regulate the immune response [22]. In the present study, Tg mice carrying a TCR transgene specific for a cII peptide varied widely in the severity of joint inflammation ... protocol for collagen-induced arthritis involving a single injection at the base of the tail of cII in CFA was used, and joint inflammation was noted for some mice begin...

Ngày tải lên: 09/08/2014, 14:22

... significantly increased airway responsiveness to cholinergic agents in Balb/c mice but not C57Bl6 mice (Figure 2A). Allergen inhalation induced increases in the TH2 cytokines IL-5 and IL-13 in both strains ... hyperresponsiveness following sensitization and challenge by intratracheal inhalation, while C57Bl/6 mice only had increases in TH2 cytokine levels, but no increase in I...

Ngày tải lên: 12/08/2014, 15:21

... in this study were arrayed at the National Cancer Institute microarray facility. All slides of each array type were printed in a single batch. The 8.7k slides contain the 8700 Incyte GEM1 clone ... staining, c-Kit pro- tein was barely detectable in normal mammary glands from nontransgenic mice and in hyperplastic mammary glands from MMTV-Wnt-1 transgenic mice, but was readily and w...

Ngày tải lên: 14/08/2014, 14:22

... respectively. Interestingly, an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of thymosin α-1 in this meta-analysis are ... nucleoside analogues, lamivudine and adefovir dipivoxil. The immunomodulators act by promoting cytotoxic T cell activity for lysis of infected hepatocytes and by stimulating cytokine pr...

Ngày tải lên: 02/11/2012, 11:17

... intermediate intermediate No intermediate intermediate intermediate yes DNA arrays na intermediate intermediate no high high low yes Indirect methods Viral load na na na yes intermediate low low yes ... high intermediate low no LiPA 5% low low-intermediate yes intermediate low low yes Florescence nd intermediate intermediate no intermediate intermediate intermediate yes MALDI-TOF <...

Ngày tải lên: 03/11/2012, 09:41