Báo cáo y học: "Unraveling the transcriptional network controlling ES cell pluripotency" pot

... is, they have the property of self- renewal. Second, when introduced into a host blastocyst they contribute to all tissues and even the germ cells of the result- ing chimeric animal: they have the ... further functional analysis. Ivanova et al. [2] then assessed the effects of the loss of each of these proteins on the ES cells’ capacity for self-renewal. To do this they devis...

Ngày tải lên: 14/08/2014, 17:22

... to the signal peptide, which mediate delivery inside host plant cells. These effectors interfere with the activity of extracellular plant hydrolases and in some cases suppress plant immunity. ... different lifestyles. For example, respiro-fermentation (the fermentation of glucose in the presence of oxygen) has evolved at least twice in this phylogeny, and in both instances there...

Ngày tải lên: 09/08/2014, 20:21

... inflammatory responses may have a beneficial effect on clinical outcome. Appropriately designed clinical trials will be necessary to answer this question. Competing interests The authors declare that they ... efficacy to diminishing the adjuvant role of HMGB1 in potentiating inflammatory res- ponses through enhanced presentation of bound mediators to their cellular receptors. A similar si...

Ngày tải lên: 13/08/2014, 19:20

... expressed constitutively and only in cell types with rhythmic target miRNA expression. Otherwise, the signal from cells where miRNA are not expressed may obscure a rhythmic signal caused by miRNA ... Figures 1, 2, 3, and 4 we plot the results of the spectral analysis of the expression level time course for individual features on the array. Each of these genes had at least two exon...

Ngày tải lên: 14/08/2014, 21:20

... conjugation process itself involves a three enzyme cascade, namely E1, E2 and E3. Of these, the E1 enzyme usually catalyzes two reactions - ATP-dependent ade- nylation of the carboxylate followed by thiocarboxylate ... core of ESCRT-III, have an archaeal origin, suggesting that many complexes functioning in the cytosol of the archaeal progenitor of eukaryotes were directly inherited b...

Ngày tải lên: 14/08/2014, 21:20

... than the threshold at which the null hypothesis is rejected, then the null hypothesis should not be rejected. The next section shows how to estimate the p- values of Equation 3 without explicitly ... the p- value formulas. The reason for maximization over W is that, if even one context has a p-value greater than the threshold at which the null hypothesis is rejected, then t...

Ngày tải lên: 14/08/2014, 07:21

... binding site Yes Yes Yes Yes Yes Yes In promoter region Yes Yes Yes Yes Yes Yes In 3'-UTR Yes No No No No No Across genomes Human, mouse and rat Human and mouse No No Yes Human Species supported ... binding sites in the T98G dataset Yes No N/A N/A N/A Yes Identified E2F-binding sites in the T98G dataset Yes Yes N/A N/A N/A Yes Search for potential miRNA involved in the dataset Ye...

Ngày tải lên: 14/08/2014, 17:22

... to characterize the participation, if any, of these proteins in the process of entry into the cell cycle of G0, growth arrested cells (G0/G1 transition) and the subsequent steps of progression through early ... either H-ras or N-ras, thus recovering expression of these genes in the corresponding null cell lines (Figures 9a- c). When N-ras expression was restored in either single...

Ngày tải lên: 09/08/2014, 20:20

... file 5Primers employed in expression analyses, and expression esti-mates for pooled samplesPrimers employed in expression analyses, and expression esti-mates for pooled samples.Click here for ... provides mean expression values for queen and worker honey bee tissue-specific samples. Additional data file 5 provides the primers employed in expression analyses, and expression estimates for ......

Ngày tải lên: 14/08/2014, 07:21

... among the physicians and nurses that this approach saves lives and improves the care of our patients. Competing interests The authors declare that they have no competing interests. References ... teams at these hospitals may have essentially functioned as METs. Recommendation Though underpowered, the results of this study provide a reliable basis for the design of future stu...

Ngày tải lên: 25/10/2012, 10:39