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Báo cáo y học: "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains" pps

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Báo cáo y học: "Patients, their doctors, nonsteroidal anti-inflammatory drugs and the perception of risk" docx

... patients from the use of a given therapy, on the other hand, even very rare seriousevents may play a role in decision-making by patients, by theirhealth care providers and by regulatory authorities. ... decision-making by patients, bytheir health care providers and by regulatory authorities.Risk is inherent to essentially all drug therapy. Anypharmacological therapy is likely to have some risk of adverseeffects ... events of even greater frequency orseverity. When only small incremental benefits accrue to patientsfrom the use of a given therapy, on the other hand, even very rareserious events may play a...
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Báo cáo y học: "Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on" pps

... either by over-expression of HDAC2 or by theophylline-induced enhance-ment of HDAC activity, indicating that strategies aimed atrestoring HDAC activity may enhance the efficacy of GCtherapy ... function of anti-inflammatory thymic-derived natural regulatory T lymphocytes[76]. Systemic treatment of mice with TSA increases the frequency of natural regulatory T cells. Either incubated withTSA ... RA. Recent findings in the study of inflammatorylung diseases demonstrate that HAT activity and HDACactivity significantly impact upon the clinical efficacy of GCtherapy [15]. GC receptor-binding...
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Báo cáo y học: " Ethnobotany, diverse food uses, claimed health benefits and implications on conservation of barley landraces in North Eastern Ethiopia highland" ppsx

... quality, taste and storability of the resultinginjera. The farmers consider the injera from these land-races as tasty and filling, soft, fluffy, spongy with good and well distributed ‘eyes’. ... qualities and other agronomic traits.Table 5 highlights the ethno-botany of some of the landraces grown by farmers, which gives some ideaabout the richness of landraces types and their manage-ment ... practiced, majority of the landraces may be planted either in the belg or meherseason depending on the onset of the rainfall. For exam-ple, the b elg rain occasionally starts very early making itpossible...
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Báo cáo y học: " Immune Restoration Syndrome with disseminated Penicillium marneffei and Cytomegalovirus co-infections in an AIDS patient" pps

... infil-trates of plasma cells and multiple granulomas with epi-theloid histiocytes. Special stains for fungus and acid fastbacilli were negative. Biopsy of the axillary lymph nodeson haematoxylin-eosin ... follicular lysis withareas of follicular hyperplasia and marked histiocytic pro-liferation. The histiocytes revealed dot-like fungal ele-ments. However, Giemsa stained smears of the lymph-BioMed ... opportunisticinfections. When highly effective antiretrovirals are givento these patients, the main focus of the treating physicianis to restore the patient's immune system rapidly. How-ever, while...
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Báo cáo y học: "A woman with diabetes presenting with pyomyoma and treated with subtotal hysterectomy: a case report" pps

... Asubtotal hysterectomy and bilateral salpingo-oophorect-omy were performed; the surgery was difficult and the patient gravely ill with heavy bleeding at surgery. The measured blood loss was 1.9 L. The ... courses of antibiotics and eventually at laparotomy, she was found to have alarge pyomyoma which was successfully removed by subtotal hysterectomy with immediate and complete resolution of her symptoms.Conclusion: ... Soares4Addresses:1Department of Obstetrics and Gynaecology, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies2Department of Pathology, University of the West Indies, Mona, Kingston...
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Báo cáo y học: "A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors Steffen Eikenberry" ppsx

... )]σΠΠ(3) The modeled tumor systemFigure 1 The modeled tumor system. The systemic circulation is connected to the primary tumor mass. The primary mass is composed of a number of individual ... unaffected. Therefore, in this study, it is not nec-essary to consider the effects of hypoxia, and I only con-sider the viable part of the tumor cord. A schematic of the circulation coupled to the ... tobe 0.6, and a body surface area of 1.73 m2 is assumed.Tumor cord geometry parametersVessel and cord radiiTumors can vary greatly in the level of perfusion and in the regularity of their vasculature....
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Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&

... satisfaction with the duration of effect of the study medication on their child'sADHD symptoms.Regarding medication satisfaction with tolerability of MTS, at study endpoint the majority of caregivers ... that the study medication decreased their child'sappetite. The majority of caregivers (88.1%) disagreedthat the study medication made their child feel sleepy dur-ing the day, but 34.8% of ... the study medication, and 91.9% were satisfied with the efficacy of the study medi-cation on their child's attention. The majority of caregiv-ers (93.1%) indicated a high level of satisfaction...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... from all the subjects. This study protocol was approved by the Ethics Committee of the Nagoya University Graduate School of Medicine. Tests for Helicobacer pylori (H. pylori) antibody and pepsinogens ... Conclusions: This study represents that the Gab1 polymorphism was associated with the low risk of H. pylori infection and the high risk of gastric atrophy among seropositive healthy controls, and that seropositive ... atrophy among the seropositive subjects [18]. The present study examined the association of a polymorphism of Gab1 with gastric cancer and gastric atrophy identified as the precursor lesion of...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

... MBP and other fusion protein expression systemshave been widely used, both because the fusions serve asefficient purification tags and because they are able topromote the solubility of the fused ... The Johns Hopkins UniversityBloomberg School of Public Health, Baltimore, Maryland, USA The presence of extra N- and C- terminal residues can play amajor role in the stability, solubility and ... highlight the central issue that solubility of fusion proteins is not necessarily indicative of either properfolding or of increased solubility of the protein of interest.We propose that the success...
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