Báo cáo y học: "Signatures of human regulatory T cells: an encounter with old friends and new" pdf

... novel antiapoptotic genes by active TP53 can significantly contribute to apoptosis [34]. Controversially, it has been reported that PTTG1 can activate TP53 and BAX to increase apoptotic function, ... is central for their development and function. These cells mature and migrate directly from the thymus and constitute approximately 2-3% of total human CD4 + T cells [3-5]. Apart fr...

Ngày tải lên: 14/08/2014, 16:21

... or more CRM with significant functional annotation. The mod- ule with the strongest GO enrichment in the synergy map con- sists of a telo-box and the UP1 motif and targets protein biosynthesis (p ... two-way clustering (white) procedure. The left and right y- axis show the frequency for the random and the potentially functional TFBSs, respectively. real TFBS nTTCCCGC random TF...

Ngày tải lên: 14/08/2014, 17:22

... statistically significant differences between control (con) culture and cultures with IL-7, with IL-4 or with IL-7 and IL-4. Significant differences between the cytokine treatments are indicated ... Institute, Kenilworth, NJ, USA), or with or without IL-7 and IL-4 (both 10 ng/ml). Cytokine analysis IFN-γ and IL-4 production were analyzed by ELISA upon costimulation with CD3/...

Ngày tải lên: 09/08/2014, 01:23

... associated with positive titers of thyroid autoantibodies (anti-thyroglobulin and/ or anti-thyroid peroxidase) and with or without a palpable goiter. Control group Caucasian females, comprised of ... diseases. Introduction It is postulated that the paternal and maternal antigens will be recognized by the immune system within the thymus, and T cells that have a high affinity f...

Ngày tải lên: 09/08/2014, 14:22

... government publications andtheses),articlesthatweretoooldtobeindexedon electronic databases, and articles without abstracts that were missed by the initial search strategy. Study selection All titles ... University of Queensland) for his statistical advice in this meta-analysis. Authors’ contributions All authors contributed equally to the conception and design of this study. SN carri...

Ngày tải lên: 10/08/2014, 21:24

... culture and CAIA in the animal model. TK and TK carried out most of the in vitro experiments. TK, NM and SY participated in the coordination of the study and manuscript preparation. All authors ... showing strong ability to bind mouse CII and activate the complement may effec- tively induce arthritis in mice; however, the relationship between the development of arthritis and...

Ngày tải lên: 11/08/2014, 03:20

... C2A-12 and/ or C2B-16 to the mAbs (CII-6, CII-3, and C2B-14) to test the arthritogenicity. We predic ted that C2A-12 would exacerbate the arthri- tis because its ability to activate complement and ... participated in the coordination of the study and manuscript preparation. All authors read and approved the manuscript. Competing interests The authors declare that they have no compe...

Ngày tải lên: 11/08/2014, 06:23

... expressed as means ± standard devi- ations. Data were analyzed using one-way analysis of variance and secondary analysis for significance with the Turkey-Kramer post test. All analyses were per- formed ... supernatant. (B) Western blot analysis: Mouse anti-His-tag monoclonal antibody was used for this analysis. The fusion protein was observed in both inclusion body and supernatant....

Ngày tải lên: 25/10/2012, 11:10

... evident to the quite effect of loading process on erythrocytes and/ or protective effect of pravastatin as investigated in previous study stated that the pravastatin protect erythrocytes against ... Osmotic fragility behavior of pravastatin loaded eryth- rocytes Osmotic fragility determines the susceptibility of erythrocytes to osmotic lysis in respect to serial dilu- tion of...

Ngày tải lên: 25/10/2012, 11:10

... ion channel activity [14] and virion incorporation of Vpr [23–25]. This suggests most of the various cellular and viral proteins that are reported to directly interact with Vpr may form hydrophobic ... suggesting an important role in early stages of infection [3–6]. Vpr is involved in the transport of the preintegration complex into the host cell nucleus, which is an importa...

Ngày tải lên: 24/03/2014, 04:21