Báo cáo y học: "Enigma variations: control of sexual fate in nematode germ cells" docx

... its activity in XO animals, causing male development. Theinactivation of TRA-2 permits three interacting cytoplasmic proteins -FEM-1, FEM-2 and FEM-3 - to direct male fates by inhibiting thetranscription ... proteins work is unclear. FEM-1 contains ankyrinrepeats [8], which often mediate interactions with other pro-teins. In vitro assays show that it binds FEM-2 [9]. FEM-2 isa PP2C-type protein ... Genome Biology 2006, 7:227commentreviewsreports deposited researchinteractionsinformationrefereed researchMinireviewEnigma variations: control of sexual fate in nematode germ cellsRonald...

Báo cáo y học: "Assessing the quantity of pulmonary edema in critically ill children" docx

... Currently, it seems that measurement of EVLW using the transpulmonary thermodilution method routinely in clinical practice may have limited value in young children. Lemson and colleagues’ study, ... accurately determined using this scoring system. e authors are to be commended for completing this study. Overall there are many challenges in the use of this method to measure EVLW in children, ... useful in children, indexing is likely to be relevant in this cohort where the range of reported weights is up to 152 kg. EVLW was inversely correlated with height in this study; this ﬁ nding...

Báo cáo y học: " Prospects for control of emerging infectious diseases with plasmid DNA vaccines" doc

... relatively streamlined period of time. In the case of potentially fatal emerging pathogens, reducing the pro-duction time of an effective vaccine may be critical in pre-venting spread of infection ... withconventional vaccine approaches (Appendix 1) particu-larly in the setting of protecting against potentially lethalemerging infectious diseases. Protecting against a particu-lar pathogen may require ... autoimmunityor anti-DNA antibodies such as those observed in Sys-temic Lupus Erythematosis have not been observed in clinical trials of DNA vaccination [12]. Interestingly, asplasmid DNA vaccines...

Báo cáo y học: "High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis

... Foundation of America. Matthew Lee (Intel Scientific Award winner) currently is in the New York University. He is involved in the investigation of Apoptosis inhibitor expression in the hepatoma ... involved in the investigation of the role of HBV proteins in the up-regulation of apoptosis inhibitor. Timothy Block Ph. D is a Professor, director of Drexel Institute for Biotechnology and Virology ... Biotechnology and Virology Research, School of Medicine, Drexel University, USA. His current researches investigate the entry of hepatitis B virus, pathology of HBV infection and hepatocellular carcinoma...

Báo cáo y học: "Hypoalbuminaemia – A Marker of Cardiovascular Disease in Patients with Chronic Kidney Disease Stages II - IV"

... (p=0.04) of CVD by multiple logistic regression analysis using the above risk factor variables. In conclusion: a) hypoalbuminaemia is an independent predictor of CVD in early CKD stages; b) hypoalbu-minaemia ... events in this population (27). In a re-cent study C-reactive protein and low albumin has been shown to be the predictor of morbidity and mor-tality in CKD 3-5 patients in Spain (31). Our study ... of these patients are on maintenance dialysis (1). CVD is the leading cause of morbidity and mortality in these patients accounting for more than 40% of hospitaliza-tions and almost 50% of...

Báo cáo Y học: Phosphorylation and dephosphorylation of histidine residues in proteins Susanne Klumpp and Josef Krieglstein Abteilung Biochemie und Institut fu¨r Pharmakologie und ppt

... disappearance of phos-phohistidine on P-selectin are very rapid.The next ﬁnding of an intracellular signaling systeminvolving histidine phosphorylation in mammals appeared in 2000 [23]. A 37-kDa protein ... 1, t ype 2 A a nd type 2C, in contrast, a re highly active against phosphohistidine in histone H4 (reviewed in [1]). Intriguingly, none of theserine/threonine phosphatases acting on histidine ... phosphatases,protein tyrosine p hosphatases and the serine/threoninephosphatase type 2B (calcineurin) do not dephosphorylateH4 phosphorylated on histidine. The serine/threonineprotein phosphatases type...

Báo cáo y học: "Evaluating the Safety of Intranasal Steroids in the Treatment of Allergic Rhinitis" docx

... 12 years andolder and in one controlled 12-week study in 558 childrenaged 2 to 11 years.20Intraocular pressure remained withinthe normal range (, 21 mm Hg) in $ 98% of the patients in any ... 42% of children were diagnosedwith AR by the age of 6 years. The prevalence of AR hasincreased dramatically in the past 30 years and continuesto increase. Children with one component of atopy ... greater risk of developinga second component.2 In 1998, the Joint Task Force on Practice Parameters in Allergy, Asthma, and Immunology defined rhinitis as‘‘inflammation of the membrane lining the...

Báo cáo y học: "A cohort study of accidents occurring in mentally handicapped patients living in institutions" pot

... and/or treat predisposing factorssuch as vitamin D deficiency, which is commonly found in this type of patient.The majority of the 1,497 minor injuries consisted of bruising (40%), wounds (35%) ... study of accidents occurring in mentally handicapped patients living in institutions Annals of General Psychi-atry 2010, 9:22Received: 7 November 2009 Accepted: 8 May 2010 Published: 8 May ... strategies.MethodsStudy designAn observational, analytical, longitudinal, prospective,repeated measures study involving accidents occurring in six institutions in the north of Spain, all of which belongto...

Báo cáo y học: "The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin" ppsx

... arginine residues in IS4VHAs reported previously, the presence of the heavy chain of IS4 plays a dominant role in binding to CL [29]. IS4VHbinds CL in combination with six of the 10 light chainstested ... sequence of IS4VH was dominant in con-ferring the ability to bind cardiolipin (CL) while the identity of the VL paired with this heavy chain was important in determining the strength of CL binding ... in IS4 variable heavy chain-region (VH) complementarity determining region 3Effect of arginine to serine point mutations in IS4 variable heavy chain-region (VH) complementarity determining...

Báo cáo y học: "Dynamic magnetic resonance of the wrist in psoriatic arthritis reveals imaging patterns similar to those of rheumatoid arthritis" pps

... significantlyhigher in PsA than in healthy controls, with only one case of overlap between the two conditions.A more efficient way of differentiating PsA from RA by MRI isto study the pattern of joint ... between indexes of severity anddynamic MRI in either PsA and RA. This last finding is surpris-ing in view of our previous results on the high correlationbetween clinical and laboratory indexes of ... intravenous bolus injection of 0.2 ml/kg of Gd-DTPA (gadolinium-diethylenetriaminepentaacetic acid)(Omniscan, Schering, Germany) was given manually in 30 sthrough a 21-mm butterfly needle into...

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