Báo cáo y học: "Chromatin remodeling and genome stability" ppsx

... double-strand breaks. Abundant acetylation of lysine 56 (K56) of histone H3 is found predominantly in newly syn- thesized histones that are incorporated into nucleosomes during S phase of the cell cycle, ... facilitate transcription from cryptic promoters. Mellor also introduced the idea that many of the epigenetic marks analyzed by researchers are dynamic, as illustrated by data from the MET...

Ngày tải lên: 14/08/2014, 16:21

... core histones, such as acetylation and phosphorylation, are freely reversible. Enzymes that catalyze these reactions exist and are well studied. Methylation of lysine and arginine residues constitutes ... chemistry of a tetrahedral methyl carbon in methyl lysine differs substantially from the planar carbonyl carbon of acetyl lysine (Fig. 2B). In fact, it is currently unknown whether lys...

Ngày tải lên: 31/03/2014, 21:21

... Central Ltd A decade and genome of change Clare Garvey, Editor, Genome Biology* E D I T O R I A L *Correspondence: Clare.Garvey@genomebiology.com Genome Biology, BioMed Central, Gray’s Inn Road, London, ... [2], Genome Biology’s long-term and beloved-of-many columnist, discusses Genome Biology’s launch, in addition to charting our success and the unique approach that has see...

Ngày tải lên: 09/08/2014, 20:21

... cap analysis gene expression (CAGE) and small RNA sequencing of mouse genome to determine the activity and transcriptional complexity of the whole genome. They subsequently identified thousands ... (University of Queens- land, Australia) and colleagues reported a novel way to map regulatory networks by surveying the transcriptional output in a model system of ES cell differentiation....

Ngày tải lên: 14/08/2014, 08:21

... Escherichia coli. Genome Biol 2004, 5:R87. 252.4 Genome Biology 2004, Volume 5, Issue 12, Article 252 Willenbrock and Ussery http://genomebiology.com/2004/5/12/252 Genome Biology 2004, 5:252 Figure ... with highly expressed genes found by Jeong et al. [1]. However, the majority of cellular DNA is compacted transiently by chromatin proteins, and there are many regions that are not hi...

Ngày tải lên: 14/08/2014, 14:21

... selection”. http://genomebiology.com/2009/10/4/306 Genome BBiioollooggyy 2009, Volume 10, Issue 4, Article 306 Ivics 306.3 Genome BBiioollooggyy 2009, 1100:: 306 Genome BBiioollooggyy 2009, 1100:: 306 Meeting ... shaping genome structure and function for millions of years, and the impact of transposons on eukaryotic genomes was the central theme of a conference held recently...

Ngày tải lên: 14/08/2014, 21:20

... interesting and diverse sympo- sium during a major microbiology conference helped disseminate systems-biology ideas amongst researchers in virology, bacteriology, mycology and parasitology. While ... phagocytosis and development. John McKinney (Swiss Federal institute of Technology, Lausanne, Switzerland) described a powerful combina- tion of microscopy and microfluidics to tempora...

Ngày tải lên: 09/08/2014, 20:21

... lysozyme gene in myeloid cells [67], and for the b-globin gene in erythrocytes [68]. Priming by SWI/SNF complexes may even apply to the myogenic determination genes themselves. It was recently ... comparatively small fraction of the otherwise constitutively hypermethylated frog genome [18]. This hypomethylated state of the XmyoD gene may contribute to a short period of ubiquitous MyoD exp...

Ngày tải lên: 31/03/2014, 21:21

... many phenotypesthatare not shared with CAF-1 mutants, including growth defects, sensitivity to double- strand DNA damage, sensitivity to hydroxyurea, suppres- sor of Ty or Spt phenotype, and ... chromatin assembly factors that have been identified biochemically and may function to mediate chromatin assembly in vivo: histone chaperones for newly synthesized H3 and H4 (ASF1 and CAF-1) a...

Ngày tải lên: 31/03/2014, 21:21

... genome was unimaginable ten years ago. Yet, remarkably, within the past two years, four different technol- ogy platforms (high density tiling arrays, pyrosequencing, sequencing by ligation, and ... by synthesis) have provided high-resolution nucleosome maps of the yeast genome. Each map, and thus each platform (Affymetrix, Roche/454, Illumina/Solexa, and Applied Biosystems), are near...

Ngày tải lên: 09/08/2014, 20:20