Báo cáo y học: "RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals" docx

... reproduction in any medium, provided the original work is properly cited. Antisense- mediated gene regulation& lt;p>The study of two examples of endogenous genes with coding or non-coding natural antisense ... interference is not involved in natural antisense mediated regulation of gene expression in mammals Mohammad Ali Faghihi *† and Claes Wah...

Ngày tải lên: 14/08/2014, 16:21

... moderate in comparison with the intrinsic variability in gene expression. Third, the expression of some genes may not be influenced by the underlying genomic change. For example, copy number gains ... is the proportion of non-influenced genes, that is, the percentage of genes whose expression is not altered by the underlying genetic alteration. The reason for using a...

Ngày tải lên: 14/08/2014, 08:20

... synthetas e arginine deiminase , resistance, RNA interference Background Arginine deiminase depletes arginine by hydrolyzing it to ci trulline. Pegylated recombinant arginine deiminase (rADI) has ... rate-limiting enzyme in synthesis of arginine from citrulline. To understand the efficiency of RNA interfering of AS in sensitizing the resistant cancer cells to rADI, the down regul...

Ngày tải lên: 10/08/2014, 05:21

... medicine. Recently, several clinical trials of RNAi therapies against cancers are ongoing. In this article, we discuss the most recent findings concerning the administration of siRNA against ... Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan. 2 Division of Internal Medicine, Kyoto Second Red Cross Hospital, Kyoto, Japan. 3 Department of Molecular Cell Ph ysiology...

Ngày tải lên: 10/08/2014, 09:22

... reduction in their incidence in some types of surgery however there exist some discrepancies in this respect. The aim of this study was to analyze the relat ionship between PaO 2 values and SSIs in cardiac ... thereby increase the PsqO 2 (tissue oxygen partial pressure), since oxidative killing by neutrophils is the primary defense against sur- gical pathogens. The risk of inf...

Ngày tải lên: 10/08/2014, 09:23

... been linked to preterm birth, inherited genetic diseases, and inflammation and may increase the risk of hypoxic injury to vital organs in new- born infants; such injuries representing ~4% of infant fatalities ... Strang LB: Syn- ergistic action of triiodothyronine and hydrocortisone on epinephrine-induced reabsorption of fetal lung liquid. Pediatr Res 1990, 27:588-591. 42. Finley N,...

Ngày tải lên: 12/08/2014, 15:21

... (RNAi) is a highly conserved mecha- nism for gene silencing in higher eukaryotes [1]. RNAi- based gene silencing utilizes 21-nucleotide duplexes (short interfering RNA or siRNA) consisting of 19 ... miRNAs in mod- ulating host-defenses. The latency-associated transcript (LAT) of herpes simplex virus-1 (HSV-1) is known to inhibit apoptosis and maintain latently infected neurons...

Ngày tải lên: 13/08/2014, 06:20

... interferon-stimu- lated genes. This process is regulated in part by the dsRNA- dependent protein kinase (PKR). As the disruption of ade- noviral VA1 RNA significantly affects the level of adenovi- rus found in infected ... precisely defined, the revelation that small RNA molecules are equipped with this regulatory function has transformed our thinking on the role of RNA in many...

Ngày tải lên: 13/08/2014, 09:21

... the characteris- tics of the individual (e.g. genotype, coping strategy, expectation and previous experiences). Given the com- plexity, it is not surprising that a variety of control inter- ventions ... acu- puncture intervention used was, according to the investi- gators, designed to minimise potential physiological effects by needling superficially at points distant from acu- points...

Ngày tải lên: 13/08/2014, 15:21

... is likely that the reduction effect was mainly caused by the study intervention (PCT algorithm), it remains unclear in how many cases the PCT algorithm was forced into action by the study physicians ... guiding antibiotic treatment decisions and for determining treatment-stopping rules [14]. Finally, it would have been interesting to know whether PCT is now implemented in their ICU as...

Ngày tải lên: 13/08/2014, 16:21