Báo cáo y học: "RNA interference has a role in regulating Drosophila telomeres" potx

... having no effect on HeT -A. For example, several aub alleles increased HeT -A expression in only a fraction of the ovaries, or sometimes only in some ovarioles in a single ovary. Only in one case ... and Tetrahymena [19]. Perhaps this is another case where the variant Drosophila telomere is sharing in a general cellular mechanism. Finally, it is important to keep in mind...

Ngày tải lên: 14/08/2014, 16:21

... 2003, 21:379-386. 4. Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, et al.: Antisense tran- scription in the mammalian transcriptome. Science ... calculated as ∆∆Ct. Additional data files The following additional data are available with the online version of this paper. Additional data file 1 is a table contain- ing sequence infor...

Ngày tải lên: 14/08/2014, 16:21

... essential role in processing small hairpin RNA (shRNA) to generate small interfering RNA (siRNA), and its function in producing mature miRNA from pre-miRNA, depletion of Dicer has proven to be a useful ... whereas a combination of the five miRNA inhibitors substantially increased virus production in sev- eral different HIV strains), it appears from the study by Huang et al. [8]...

Ngày tải lên: 13/08/2014, 06:20

... function has transformed our thinking on the role of RNA in many facets of biology, illustrating the complexity and the dynamic interplay of cellular regulation. As plants and invertebrates lack the ... Biology, Monash University, Clayton, Australia Email: Johnson Mak* - mak@burnet.edu.au * Corresponding author RNA silencingsiRNAmiRNAHIVPFV-1vertebrateimmunityviral invasion Abstract I...

Ngày tải lên: 13/08/2014, 09:21

... deiminase , resistance, RNA interference Background Arginine deiminase depletes arginine by hydrolyzing it to ci trulline. Pegylated recombinant arginine deiminase (rADI) has been used as an anti-cancer ... clinical application of rADI in cancer therapy. Argininosuccinate synthetase (AS), a rate-limit ing enzyme in the citrulline-arginine regeneration pathway, has been reported to...

Ngày tải lên: 10/08/2014, 05:21

... 61:850-862. 14. Ochiya T, Takahama Y, Nagahara S, Sumita Y, Hisada A, Itoh H, Nagai Y, Terada M: New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet. Nat Med 1999, 5:707-710. 15. Song ... liver metastases of lung cancer. Mol Cancer Ther 2008, 7:2904-2912. 52. Nogawa M, Yuasa T, Kimura S, Tanaka M, Kuroda J, Sato K, Yokota A, Segawa...

Ngày tải lên: 10/08/2014, 09:22

... 5'- GCTTTTCCAAAAAATGGAGAGATGAAGAAATAT- TCTCTTGAAATATTTCTTCATCTCTCCACG-3'; pSi-C 2 , forward 5'- ATCCGAAAGTATATGTACCAAGATTCAAGAGATCTTGG- TACATATACTTTCTTTTTTGGAAA-3', pSi-C 2 , reverse 5'- AGCTTTTCCAAAAAAGAAAGTATATGTACCAA- GATCTCTTGAATCTTGGTACATATACTTTCG-3'. ... 5'- GATCCGTTACACTATTAACAACAAATTCAAGAGATTT- GTTGTTAATAGTGTAATTT TTTGGAAA-3', pSi-4, reverse: 5-...

Ngày tải lên: 12/08/2014, 15:21

... the protein kinase Tor is a well known regulator of growth and can alter cell size in both Drosophila and mammals [10]. Activating insulin/Tor signaling increases cell and organism size, whereas inhibiting ... scale. For example, the data generated can be analyzed and presented in various ways to highlight the different phenotypic effects (see the supplementary data accompanying [9])....

Ngày tải lên: 14/08/2014, 16:21

... test has no problem in the detection of anti-ribosomal P La-He Jearn and Think-You Kim Department of Early Arthritis/Laboratory Medicine, The Hospital for Rheumatic Diseases, Hanyang University ... the autoimmune target (AIT) test and it participates in the quality control program run by the Korean Society of Laboratory Medicine [3]. In 1999 and 2007, reports of antinuclear antibody t...

Ngày tải lên: 09/08/2014, 14:21

... antibodies. By contrast, many laboratories rely on HEp-2 cell substrates that are widely available as FDA and CE approved diagnostic kits from a variety of manufacturers. In their study, Jearn and Kim identified ... perform remarkably better. In the context of contemporary diagnostic assays such as WB, ELISA or multiplexed addressable laser bead immuno- assays, therefore, the data prese...

Ngày tải lên: 09/08/2014, 14:22