Báo cáo y học: "The next epidemic" doc

... about everything bad that can happen physically. Cancer (most types, anyway) and heart disease are just two of the conditions that afflict the elderly much more fre- quently than the young. Osteoporosis, ... diseases are typically slowly progressing with variable rates of decline and complex symptomology. Picking a suitable clinical end-point is hard enough, but when you add to it the likely...

Ngày tải lên: 14/08/2014, 16:21

... strategy for studying biological systems than as a field of biology. Systems approaches have been very successful in the realms of biochemistry and genetics, especially for genetically tractable ... of most labs. Second, the costs of systems biology scale sub-linearly while the payoffs scale super-linearly. Put simply, screening 100 times as many genes yields more than 100 times the inf...

Ngày tải lên: 09/08/2014, 20:21

... supported by a high posterior probability (>0.9) in the Bayesian analysis; and that partition is also supported by ML analysis. This methodology bears some similarity to that proposed by Hallet ... Information Theory: 1973; Budapest, Hungary Edited by: Institute of Electrical & Electronics Engineers. Piscataway, NJ; 1973:267-281. 21. Ronquist F, Huelsenbeck JP: MrBayes 3: Bayesian phy...

Ngày tải lên: 14/08/2014, 07:21

... that’s true before my own life is over. Wouldn’t you? 116.4 Genome Biology 2005, Volume 6, Issue 8, Article 116 Petsko http://genomebiology.com/2005/6/8/116 Genome Biology 2005, 6:116 hydrogen sulfide ... especially over interplanetary distances, satisfying some nebulous thirst to see and touch for ourselves is enough justification for huge expenditures of public money when we have so many un...

Ngày tải lên: 14/08/2014, 14:21

... either polyethylene glycol (PEG)ylated albumin or a commercially available hydroxyethyl starch-based colloid in a hamster haemorrhage model. PEGylated albumin was superior to hydroxyethyl starch, ... colleagues [1] assessed the effects of haemodilution with either poly- ethylene glycol (PEG)ylated albumin or a commercially avail- able hydroxyethyl starch-based colloid in a hamster haemor- rha...

Ngày tải lên: 13/08/2014, 11:22

... the variability within any given species. It is clear that a species is not adequately represented by a single genome unless the species is evolutionarily young and rela- tively monomorphic. ... discussed on many occasions. As pointed out by W. Ford Doolittle (Dalhousie University, Halifax, Canada), the notion of a bacterial species is classi- cally defined as a “uniform and stable way for na...

Ngày tải lên: 14/08/2014, 14:22

... Holliday junctions The stoichiometry analysis presented here (see Table 1), clearly shows that two RuvA tetramers bind to synthetic Holliday junctions, which is in agreement with the crystal structure ... Molecular Biology and Biotechnology, University of Sheffield, UK; 4 Krebs Institute, Centre for Chemical Biology, University of Sheffield, UK The RuvABC resolvasome of Escherichia coli catalyses...

Ngày tải lên: 21/02/2014, 01:21

... is translocated by an insertion–deinsertion cycle of SecA into the SecYEG translocon [8]. Energy for the translocation process is provided by ATP hydrolysis by SecA [8,9] and by the proton-motive ... membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF. Cell 83, 1171–1181. 9. Duong, F. & Wickner, W. (1997) The SecDFyajC domai...

Ngày tải lên: 08/03/2014, 09:20

... and refolding trials of pig kidney 3,4 dihydroxy phenyl alanine decarboxylase. Biochem. J. 295, 493– 500. 10. Uversky, V.N. & Ptitsyn, O.B. (1994) ‘‘Partly folded state’’, a new equilibrium ... Bhattacharyya, Bose Institute, Kolkata and Prof U. Chowdhury, University of Calcutta for their suggestions and various helps. We also thank Dr B. Sanyal, Department of Physics, Uppsala University f...

Ngày tải lên: 08/03/2014, 23:20

... catalytic action of [NiFe]-hydrogenases [7]. The study of hydrogenases in methanogens led to the discovery of a third class of hydrogenases, not containing any metals [9]. This class of enzyme ... ready and unready hydrogenase from Chromatium vinosum. Biochim. Biophys. Acta 1119, 157–168. 42. Cammack, R., Frey, M. & Robson, R. (2001) Hydrogen as a Fuel. Learning from Nature. Taylor ... th...

Ngày tải lên: 17/03/2014, 10:20