Báo cáo y học: "Novel gene and gene model detection using a whole genome open reading frame analysis in proteomics" ppt

... identifications made by MS/MS and database search. Anal Chem 2002, 74:5383-5392. 23. Sadygov RG, Yates JR 3rd: A hypergeometric probability model for protein identification and validation using tandem ... this analysis. The collaborative HUPO Plasma Pro- tein study and the data analysis presented here have been supported by a trans-NIH grant supplement 84982 administered by t...

Ngày tải lên: 14/08/2014, 16:21

... hypervariable (HV) genes in patients with juvenile rheumatoid arthritis (JRA). Tabular data from the HV gene analysis was analyzed using Pathway Assist software. The graphical output delineating ... behavior dynamics are modulated in populations (denoted hypervariable gene analysis) , and DFA to identify the genes and molecular pathways involved in the patho- genesis of pol...

Ngày tải lên: 09/08/2014, 01:23

... Belmont AS, Huang S: Upstream binding factor associ- ation induces large-scale chromatin decondensation. Proc Natl Acad Sci USA 2004, 101:15106-15111. 9. Gowrishankar J, Harinarayanan R: Why is transcription ... might vary along the chromosome and also with time, because, for example, an RNA polymerase can wrap DNA around it (a restrained toroidal supercoil) and then release the DNA late...

Ngày tải lên: 14/08/2014, 14:21

... fish, insects and worms, and yeast and plants). A gene with a homolog only in mammals is considered a mam- malian gene, and a gene with a homolog only in the primates is considered a primate gene ... estimate gene age. ER, evolutionary rate. Homo sapiens Pan troglodytes Macaca mulatta Internal Node Human Lineage (a) (b) Homo sapiens Mammals Fish Insects, Wor...

Ngày tải lên: 14/08/2014, 21:20

... was achieved by acid hydrolysis of a known gravimetric quantity of lyophilisate followed by amino acid analysis using an Applied Biosystems PTH-amino acid analyser. cDNA cloning Dorsal skin was ... Bertaccini, G. & Erspamer, V. (1966) Pharmacolo- gical data on phyllokinin (braykinyl-isoleucyl-tyrosine-0-sulphate) and bradykinyl-isoleucyl-tyrosine. Br.J.Pharmacol.27, 479–485. 16. Y...

Ngày tải lên: 21/02/2014, 15:20

... the following scale: 0 = no bone damage, 1 = tissue swelling and edema, 2 = joint erosion, and 3 = bone erosion and osteo- phyte formation. Data analysis Data were analyzed using one-way analysis of variance ... was evaluated for its anti-inflammatory activity against TPA-induced edema formation and inflammatory gene expression as well as NF-κB activity in mice. Topical appl...

Ngày tải lên: 09/08/2014, 14:22

... Kaji K, Saito Y, Matsushita Y, Kawara S, Yasui M, Seishima M, Ozaki S, Kuwana M, Ogawa F, Sato S, Takehara K: Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients ... amino-acyl-tRNA synthetases (ARSs) which catalyze the binding of amino acids to the corres ponding tRNAs. Each amino acid has a separate ARS, and autoantibodies targeting 8 of the 2...

Ngày tải lên: 12/08/2014, 15:22

... COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA Early Edition (accessed at www.pnas.org/cgi/doi/10.1073/pnas.1624688699). 99:13926-13931. Correspondence Marc ... Hochberg Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are the cornerstone of therapy for relief of pai...

Ngày tải lên: 09/08/2014, 01:21

... α-phenyl-N- tert-butyl nitrone (PBN) was originally developed as a means of trapping and detecting free radical intermediates [7]. PBN and related nitrones have a variety of anti-inflam- matory and ... inoculation of bacteria and continued until day 10. Positive values indicate amelioration of arthritis and negative values indicate increased severity of arthritis between days 3...

Ngày tải lên: 09/08/2014, 03:24

... the release of proinflammatory cytokines and leads to a higher expression of TLR2. In ankylosing spondylitis (AS), as in other immune-mediated diseases, an unusual proinflammatory and cytotoxic ... the innate and adaptive immune sys- tems are crucial to promote proinflammatory reactions against pathogens and to ensure maintenance of vital self-tolerance. TLRs are expressed on bo...

Ngày tải lên: 09/08/2014, 07:20