Báo cáo y học: "Mutation patterns of amino acid tandem repeats in the human proteome" ppt

... we determined that the vast majority of amino acid substitutions could be explained by single non-synonymous nucleotide changes. Inspection of the types of amino acid substitutions in repeats ... deeper insight into the substitution patterns in repeats and adjacent regions can be obtained by the analysis of the types of amino acid substitutions, as we...

Ngày tải lên: 14/08/2014, 16:21

... amino- acid composition of hyperthermophilic proteins is the bias against thermally labile amino- acid residues. This pattern is obvious on examination of the amino- acid compositions of the total protein content of ... As both the E a of inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increase from the apoenzyme t...

Ngày tải lên: 22/02/2014, 07:20

... impulsivity. The P4 was designed by one of the consultant child psychiatrists in the team and has been in use for 15 years as one of the tools available for screening the core symptoms of ADHD. The ... DeCory HH, Hatch SJ: Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day: preliminary indications...

Ngày tải lên: 09/08/2014, 01:21

... 86 sequences of 431 nucleotides within the HBsAg region. The evolutionary history was inferred using the Neighbor-Joining method. The evolutionary distances were computed using the Maximum Composite ... are in the units of the number of base substitutions per site. There were a total of 431 positions in the final dataset. Phylogenetic analyses were conducted in M...

Ngày tải lên: 12/08/2014, 02:20

... impor- tant for the interaction of this domain with negatively charged cellular polymers, replacement of basic lysine amino acid residues by acidic glutamic acid could alter the Virus infecting human cells ... located at the outer part of the protein [19]. Additionally, one non- synonymous mutation leading to a transition from the basic amino acid lysine to the a...

Ngày tải lên: 13/08/2014, 05:22

... residing in the linear spacing and pairing of their six conserved cysteine residues. While α- defensins are expressed by neutrophils and intestinal Paneth cells, β-defensins are mainly produced by epithelia ... genes in the IIPGA. In particular, the 2 kb upstream of the translation initiation site of other innate immunity genes genotyped for AA and EA were retrieved only i...

Ngày tải lên: 14/08/2014, 21:20

... multiplicity testing by con- trolling the false discovery rate [27]. The differences between the transcriptional profiles induced by the six toxicants were less prominent in the datasets from the 4-24 ... of neurons in the brain. In in situ hybridization experiments, strong elevation of thioredoxin-like mRNA levels in response to Cd and MeHg was also noticed in th...

Ngày tải lên: 14/08/2014, 08:20

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... confirmed by sequencing DNA samples of 51 healthy individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20%...

Ngày tải lên: 31/10/2012, 16:49

... of the start of the ORF and downstream of the end of the ORF were taken as the promoter and termina- tor, respectively. These 400-bp windows were divided into ten bins of 40 bp each, and Affymetrix ... midpoint. In order to calculate an average of every exon-intron-exon junction without counting probes multiple times, the last t en bins of every upstream exon, the...

Ngày tải lên: 09/08/2014, 23:20

... this may be the case for the GM-CSF promoter in alveolar macrophages from smokers [46]. Also another interest- ing study investigating the effect of pro-inflammatory cytokines in intestinal alkaline ... acetylation in the Peyer’ s p atches found in the small intestine. Acetylate d histones are indi- cated by the brown colour in the micrographs. Pan acety- lated H3 wa...

Ngày tải lên: 11/08/2014, 03:20