Báo cáo y học: "Ranked prediction of p53 targets using hidden variable dynamic modeling" potx

... 80 100 120 140 GADD45α p21 GAPDHHDM2 Relative expression 0 Gy 0 Gy 0 Gy 0 Gy 5 Gy5 Gy5 Gy5 Gy 0 Gy 0 Gy 0 Gy 0 Gy 5 Gy5 Gy5 Gy5 Gy ControlControl siRNAp53 siRNAp53 (b) ... Mathematical methodology, below). The inclu- Experimentally determined p53 activity profileFigure 3 Experimentally determined p53 activity profile. The activity profile of p53 was measured by Western blot ... for...

Ngày tải lên: 14/08/2014, 16:21

... year of publication, country of origin, ethnicity, number of cases and con- trols, genotype frequencies for cases and controls. Meta-Analysis. The risk of esophageal cancer associated with p53 ... muta- tions in one p53 allele are highly susceptible to cancer: they develop cancer very early in life and at very high frequencies. [42,43] The functional impact of this p53 p...

Ngày tải lên: 25/10/2012, 11:40

... Vermont Longitudinal Study of Persons With Severe Mental Illness, I: Methodology, Study Sample, and Over all Status 32 Years Later. Am J Psychiatry 1987, 144:718-726. 6. Tyrer P: Evaluation of rehabilitation ... significantly later in the six year study period and had already spent significantly longer in hospital. People who were admitted to rehabilitation within the first ten years of...

Ngày tải lên: 11/08/2014, 15:22

... and total hemolytic complement CH100 by lysis of antibody-coated sheep erythrocytes (The Binding Site). All other parameters were quantified using enzyme- linked immunosorbent assay [IgE, interleukin ... The effect of short-term prophylactic methylprednisolone on the incidence and severity of postpericardiotomy syndrome in children undergoing cardiac surgery with cardiopulmonary bypas...

Ngày tải lên: 12/08/2014, 18:21

... Sempala SD, et al: Syncytium- inducing and non-syncytium-inducing capacity of human immunodeficiency virus type 1 subtypes other than B: phenotypic and Raymond et al. Retrovirology 2011, 8 :56 http://www.retrovirology.com/content/8/1/56 Page ... case of clonal analysis. The entry phenotype of the 67 subtyp e D viruses had been determined with the MT2 assay or with the Trofile ® assay (M...

Ngày tải lên: 13/08/2014, 01:21

... com- parison of pulse dye densitometry and Dill and Costill's meth- ods. Life Sci 2006, 78:1564-1569. 7. He YL, Tanigami H, Ueyama H, Mashimo T, Yoshiya I: Measure- ment of blood volume using indocyanine ... T, Ueyama H, Oi Y, Fukuda I, Ishihara H, Kohase H, Kotake Y, Koyama K, Miyao H, Kobayashi N: Determination of the stand- ard value of circulating blood volume during anes...

Ngày tải lên: 13/08/2014, 11:23

... biosynthesis of pyrimidine ribonucleotides * Salvage pathways of pyrimidine ribonucleotides * De novo biosynthesis of pyrimidine deoxyribonucleotides * Salvage pathways of pyrimidine deoxyribonucleotides ... the lysine degradation and tryptophan degradation pathways. The dihy- drofolate synthase hole in formylTHF biosynthesis was filled by the enzyme (LocusLink ID 2356) catalyzing the...

Ngày tải lên: 14/08/2014, 14:21

... only major defect caused by inhibition of IR internalization was impaired Shc tyrosine phosphorylation and MAPK activation. In summary, most of the acute actions of insulin could be initiated by ... targeting technology to identify physiological substrates of PTPs [26]. CANDIDATE IR PTPs As a first step to identify PTP s that play a regulatory role in insulin signaling pathway, several...

Ngày tải lên: 17/03/2014, 23:20

... the last three steps of the algorithm are concerned, they are closely related to the practical implementation of our methodology, hence they will be described extensively in Section 4. 4 Evaluation In ... kind of regularity and that they can be exploited in order to draw a net of implicit rules by means of a machine learning approach. Section 2 deals with previous work done on...

Ngày tải lên: 31/03/2014, 01:20

... NH, Kwak JY, Lee YC, Cho YS, Kim HC, Chae YM, et al.: Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP. Biochem Biophys Res Commun 2003, ... vivo Yasuo Kunugiza 1,2 , Tetsuya Tomita 2 , Naruya Tomita 3 , Ryuichi Morishita 1 and Hideki Yoshikawa 2 1 Division of Clinical Gene Therapy, Osaka University Graduate School o...

Ngày tải lên: 09/08/2014, 08:22