Báo cáo y học: "Deciphering cellular states of innate tumor drug responses" ppt

... which an integrated representation of the molecular pathways involved in innate drug responses can be built. Systems view of molecular pathways underlying innate drug resistance Information obtained ... global systemic view of cellular states, constitutes a helpful starting point to identify by-pass chemotherapy schemes designed to stimulate or inhibit a variety of targets...

Ngày tải lên: 14/08/2014, 16:21

... is utility, in addition to the novelty and feasibility of the prior knowledge states. A technology-based solu- tion may be feasible and novel in a laboratory setting, but utility is only achieved ... of the research knowledge into other states. Their relevance t o health and quality of life require expanding the underlying definition of knowl- edge. By differentiating the various s...

Ngày tải lên: 11/08/2014, 05:21

... macrophage colony-stimulating factor. 281 CFU-M = colony-forming-unit megakaryocyte; COX-2 = cyclooxygenase; ELISA = enzyme-linked immunosorbent assay; GM-CSF = granulocyte–macrophage colony-stimulating ... spontaneously produced in organ cultures of synovial tissues derived from RA patients. Addition of anti-inflammatory cytokines IL-4 and IL-13 completely inhibited the production of I...

Ngày tải lên: 09/08/2014, 06:22

... informa- tive sets of genes whose expression changes during therapy Editorial Predicting the future of anti -tumor necrosis factor therapy Cornelis L Verweij Division of Inflammatory Disease Profiling, ... Essentially, two phases of unresponsiveness might be identified: a primary phase directly after the start of treatment and a secondary phase that develops in initial responders d...

Ngày tải lên: 09/08/2014, 14:21

... community dynamics and predict ecosystem level impacts of changes in community membership and structure. Binning is particularly challenging for lower-abundance organisms, which may play keystone ... * Department of Earth and Planetary Science, University of California, 307 McCone Hall, Berkeley, CA 94720, USA. † Department of Environmental Science, Policy, and Management, Universi...

Ngày tải lên: 09/08/2014, 20:20

... exactly novel miRNAs evolve and what roles they have in the establishment of tissue identity. According to the model of transcriptional control of new miRNA genes suggested by Chen and Rajewsky ... for the maintenance of cells in differentiated states. It is likely, then, that miRNAs facilitate evolution of complexity by stabilizing existing and newly emerging regulatory circui...

Ngày tải lên: 09/08/2014, 20:21

... likelihood ratio of the most likely genotype to the genotype in question and consequently the likelihood ratio of the most likely genotype will be 1. As there are only 16 possible genotypes, it is ... heterozygosity (theta) of 0.001; 2, posi- tions of read depths lower than 4 or higher than 100 were excluded; 3, a Phred-like consensus quality cutoff of no higher than 100. Only uniqu...

Ngày tải lên: 09/08/2014, 22:23

... how viruses t ransform cellular states by their encoded miR- NAs, we adopted KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis to identify pathways regulated by viral miRNAs to provide ... kcal/mol. Functional similarity measurement of viral miRNAs We have previously proposed a method for systematic study of functional similarities among miRNAs by using their target...

Ngày tải lên: 10/08/2014, 09:22

... with mildly delayed hypopharyngeal contraction but no contrast retention. Flexible bronchoscopy showed normal airway anatomy. The BAL fluid contained 16% neutrophils, 35% lym- phocytes, 35% macrophages ... which the symptoms of chronic cough disappeared. Case 2 A 10-year old African-American female with Down syn- drome was evaluated by our pulmonary service for history of chronic daily co...

Ngày tải lên: 13/08/2014, 08:20

... score Average quality score Percent of reads Quality scores are of limited use in predicting accuracy of unknown sequencesFigure 2 Quality scores are of limited use in predicting accuracy of unknown sequences. ... to detect the position of miscalled bases. The interpretation of chromatograms by programs such as PHRED [13] employs quality scores that reflect the probability of...

Ngày tải lên: 14/08/2014, 07:22