Báo cáo y học: "Partners in dicing" pot

... variety of proteins involved in these pathways. Finding the partners Reasoning that proteins involved in guiding Dicer to the dif- ferent pathways should physically interact with the Dicer protein, ... also physically interacts with the proteins of this group. Interest- ingly, not all mutants in this group affect all types of small RNAs to the same extent, indicating that we are only j...

Ngày tải lên: 14/08/2014, 16:21

... obtained by analytical ultracentrifugation using the direct binding assay as des- cribed in Experimental procedures. Inset: Linearized plot of the binding data for apoE(263–286) (symbols) shown in ... possessing a similar apparent binding affinity (K d ) for the large lipid particles, are notably distinct in their maximum binding capacities (Table 2). In particular, the binding footpri...

Ngày tải lên: 08/03/2014, 09:20

... existense of three dinstict domains, namely: the highly conserved J domain consisting of approximately 70 amino acids a nd known to mediate the hsp70 binding; the glycin e/phenylalanine (G/F) rich ... were used in order to determine the subc ellular localization of the farnesylated and the nonfarnesylated forms of Mydj2 protein by Western blotting analysis, using the same anti-dj2 Ig as in...

Ngày tải lên: 17/03/2014, 17:20

Ngày tải lên: 08/08/2014, 18:20

... Rhinosinusitis Recurrent acute rhinosinusitis Chronic purulent rhinosinusitis Chronic hyperplastic rhinosinusitis Chronic rhinosinusitis with polyposis Samter’s triad 3 Allergic fungal rhinosinusitis 4 Eosinophilic ... (chronic hyperplastic rhinosinusitis) but without polypo- sis and those patients with diffuse sinonasal polyposis with polyps projecting into or com- pletely occluding the nasa...

Ngày tải lên: 08/08/2014, 20:23

... proteins. It is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the antibody responses, inflam- mation, ... sampling they have started to use medication and even after discharge from the hospital continued to use supporting therapy, which may interfere the results of this study. Hemoly...

Ngày tải lên: 08/08/2014, 21:20

... bio- logical function of the enzyme. Indeed, the null mutation in MMP-2 engineered in mice results in a very mild pheno- type, manifested mainly by a decrease in bone length [9]. It has been ... the replacement of a tyrosine by a stop codon (Y2 44X). In another family, there was a missense mutation that predicted the substitution of an arginine by a histidine (R101H). In affected...

Ngày tải lên: 09/08/2014, 01:21

... is being directed towards the role of cytokines and signalling pathways in the regulation of the MMPs in disease. Blocking of certain cytokines or inhibiting the inflammatory cell signalling path- ways ... the cytokine signalling pathways [130]. Finally, there is interest in the synthesis of modified TIMPs that are specifically targeted to inhibit specific enzymes [131–133]. It is inter...

Ngày tải lên: 09/08/2014, 01:21

... homology to other HA-binding link proteins. The two basic clusters (gray segments in Fig. 1A, inset a) are involved in HA binding: the first (located inside the link module and overlapping the ... to HA binding are also shown in Fig. 1A, inset a. Cys-266 in the transmembrane domain (Fig. 1A, inset b) is important for HA binding in Jurkat cells. Cys-266 and Cys-275 can be used for pa...

Ngày tải lên: 09/08/2014, 01:21

... Further RCTs on early SSc are needed to assess the real efficacy of CYC in inducing remission and increasing survival. In a previous issue of Arthritis Research & Therapy, Nannini and colleagues ... by a well-conducted meta-analysis and concluded that cyclophosphamide (CYC) treatment does not induce a statistically significant improve- ment in lung function in systemic sclerosis (...

Ngày tải lên: 09/08/2014, 01:22