Báo cáo y học: "The system is broken" pps

... been this bad before. They were about the same in the early 1970s. But it is true that they have never been worse. When a scientist doing work in genomics, or cell biology, or biochemistry, or immunology ... generosity of spirit is in danger of being replaced by unenlightened self-interest. Every funded proposal now is a direct threat to one’s own grants being funded. This mentality ine...

Ngày tải lên: 14/08/2014, 16:21

... Intheirlifetime,noonehaseverpipettedanythingby mouth. • DNAsequencing,peptidesynthesis,chemicalanalysis, and gene synthesis have always been farmed out to specialty companies rather than done in one’s own lab. • ey have ... have almost certainly never seen anyone blow glass. In fact, many of them may not know that test tubes were ever made of anything but plastic...

Ngày tải lên: 09/08/2014, 20:22

... a much higher risk in African Americans (RR approximately 3.5). The associated haplotype is likely to confer risk to myocardial infarction through an upregulation of the leukotriene pathway. As in ... genome-wide geno- typing or technologies for high-density comparative genome hybridization (CGH). A highlight of the meeting was the keynote lecture by Nobel laureate Sydney Brenner (Salk Inst...

Ngày tải lên: 14/08/2014, 17:22

... in the embryonic nervous system, in the adult mammalian CNS netrin 1 is expressed by oligodendrocytes, the myelinating cells of the CNS. It is enriched in non- compact oligodendrocyte membranes ... family are essential chemotropic guidance cues that direct cell and axon migration in the developing nervous system during embryogenesis. The significance of this function is particul...

Ngày tải lên: 09/08/2014, 20:20

... not for citation purposes) tissues may increase lactate production due to an enhanced glycolytic rate. This is regulated by cellular transcription factors such as the hypoxia-inducible factor 1 ... cell type-specific manner. HIF-1 promotes the formation of lactate from pyruvate by activating lactate dehydrogenase and inducing pyruvate dehydrogenase kinase 1, an enzyme that drives pyruvate a...

Ngày tải lên: 13/08/2014, 18:22

... cchhoolleesstteerrooll hhoommee oossttaassiiss aanndd bbeeyyoonndd:: tthhee ooxxyysstteerrooll hhyyppootthheessiiss rreevviissiitteedd aanndd rreevviisseedd Prog Lipid Res 2008, doi:10.1016/j.plipres.2008.04.002. 69. ... Hog proteins are found in many protists, but the Hh family emerged only in early metazoan evolution. HhN is modified by cholesterol at its carboxyl terminus and by palmi...

Ngày tải lên: 14/08/2014, 21:20

... packaging system may comprise the synergistic influences of the Rev/RRE sys- tem and cis elements from the 5’ UTR, as well as nucleocapsid protein. Considering this possibility, we sought to directly ... the Rev/RRE system is a part of the encapsidation mechanism. However, it is well established that encapsidation is primarily mediated through cis elements in the 5’ UT R, predominan...

Ngày tải lên: 13/08/2014, 01:21

... methyl 6-deoxy-6- isothiocyanato-a- D -glucopyranoside (1e)[24],andb- D - glucopyranosyl isothiocyanate (3c)[25]werepreparedby the reported procedures. Methyl 6-O-chloroacetyl-a- D - glucopyranoside ... site. EII Glc is rapidly inactivated by the 6-O-bromoacetyl esters of methyl a- D -glucopyranoside (1a)andmethyla- D -manno- pyranoside (1c), methyl 6-deoxy-6-isothiocyanato-a- D - glucopyra...

Ngày tải lên: 21/02/2014, 01:21

... Genetics, Biochemistry and Ecology of Cellulose Degradation. (Ohmiya, K., Sakka, K., Karita, S., Hayashi, H., Kobayashi, Y. & Kimura, T., eds), pp. 134–143. Uni Publishers Co Ltd, Tokyo. 38. Schopplein, ... pectin. This is in agreement with a previous study in which the synergy of enzymes degrading the pectin side chains was studied [34]. GALA had a positive effect on the activity of t...

Ngày tải lên: 21/02/2014, 01:21

... describe d in Materials a nd methods. Enzyme activity was a nalysed by the standard assay and the i mmunoreactivity was detected by Western blot analysis and quantitated as described i n Materials ... 2002 This amino acid is located in the insert within the catalytic domain, close to the catalytic His264, and the proximity to the active site may explain the effect of oligomerization on enzy...

Ngày tải lên: 21/02/2014, 15:20