Báo cáo y học: " Rats go genomic" ppt

... a panel of phenotypically characterized rat recombinant inbred strains. This systematic approach resulted in the mapping of many novel cis- and trans-regulatory control elements. A study of the cis-regulated ... highly linked eQTLs revealed attractive candidate genes for previously mapped QTLs for metabolic and cardio- vascular disease phenotypes. The trans-regulatory eQTL dataset is more lik...

Ngày tải lên: 14/08/2014, 16:21

... are exclusively discovered by each data type. Figure 3B shows the additional sets discovered by integrative and meta-analytic approaches but not by any of the single-data-type analyses (see Methods ... pathway may be sufficient to generate a phenotypic difference. If this hit can occur in any of several components in the pathway, individuals with the same phenotype may show variability i...

Ngày tải lên: 09/08/2014, 23:20

... good test case to study how gene networks change as animals evolve, but they are only one part of a story that will prove yet more complicated. Acknowledgements We are indebted to Pawel Herzyk ... longer, consistently show more Hox- responsive targets than the younger embryos, suggesting that the proportion of secondary targets may be greater in the older embryos. Similarly, it should be ......

Ngày tải lên: 14/08/2014, 18:20

... therefore most commonly performed Monday (day 0), Wednesday (day 2), and Friday (day 4). On day 0, the allergens are applied to rows of aluminum or plastic chambers mounted on hypoaller- genic porous ... reactions occur early and fade quickly, whereas allergic reactions exhibit a crescendo pattern over many days. It is therefore not recommended to perform only one reading at day 2 as many tru...

Ngày tải lên: 08/08/2014, 21:20

... in Otolaryngology: Proceedings of the First International Academic Conference in Immunology and Immunopathology as applied to Otology and Rhinology. Edited by Veldman JE, McCabe JE, Huizing EH, Mygind ... preven- tion by treatment based on antineutrophil cytoplasmic anti- body level. Lancet 1990, ii:709-711. 44. Jayne DRW, Gaskin G, Pusey CD, Lockwood CM: ANCA and predicting relapse in system...

Ngày tải lên: 09/08/2014, 01:21

... nonlinearly over time [7]. Whether the elevated serum COMP levels are influenced by COMP released from ligaments and tendons – the very structures increasingly recognised as being involved in early disease ... of serum cartilage oligomeric matrix protein levels over five years. Arthritis Rheum 2004, 50:2479- 2488. 8. Tan AL, Grainger AJ, Tanner SF, Shelley DM, Pease C, Emery P, McGonagle D: H...

Ngày tải lên: 09/08/2014, 10:22

... URL. Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis<p>By comparing two fully sequenced genomes of <it>Chlamydia trachomatis </it>using competitive hybridization ... identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis.</p> Abstract By comparing...

Ngày tải lên: 09/08/2014, 20:20

... back- grounds that have not yet been assayed. were non-synonymous. Out of 80 variants that Giacomini’s group followed up by individually expressing the corre- sponding synthetic variants in cells, ... the Keystone Symposium ‘Biological Discovery Using Diverse High-Throughput Data’, Steamboat Springs, USA, 30 March-4 April 2004. The 2004 Keystone Symposium meeting ‘Biological Discovery Using ....

Ngày tải lên: 09/08/2014, 20:20

... host jumps by oomycetes, as described by Marco Thines (University of Hohenheim, Germany). His talk highlighted insights gleaned from the study of several species of the clade Hyaloperonospora, ... complementary to the projects in UNICORN, showing how the systematic comparative analysis of core and accessory genes of chytrids can shed light on the origin of complex eukaryotic features...

Ngày tải lên: 09/08/2014, 20:21

... No, Venter and Smith aren’t playing Frankenstein, and they aren’t playing God either. What they’re really playing is omas Edison. ere is no divinity in this work; quite the opposite. ... citizen shouldn’t worry too much about synthetic biology, at least not yet. e ones who should worry are the synthetic chemists, because living organisms can make many polymers and drugs and ... have...

Ngày tải lên: 09/08/2014, 20:22