Báo cáo y học: "Identifying repeat domains in large genomes" pot

... identify repeat domains by ana- lyzing repeat family libraries that are obtained via other means. The main challenge in the analysis of repeat domains is that repeat family consensus sequences typically ... protein domains is a well-established research area, the study of repeat domains is still in its infancy. Indeed, RepeatGluer [17] is the only existing algo- rithm fo...

Ngày tải lên: 14/08/2014, 16:20

... cardiac injuries, at least partially by shifting the microenvironment at the injury sites from proinflammatory to anti-inflammatory [55-57]. In a murine pulmonary fibrosis model, MSCs inhibited ... study by Friedenstein and colleagues [1] more than 40 years ago, the field of MSC investigation has gained increasing attention and popularity, particularly in the past decade. Using ‘mesenchym...

Ngày tải lên: 09/08/2014, 13:22

... prophylaxis in trauma patients may be the lack of intra-institutional data concerning the inci- dence of clinically important bleeding. Only 27% of the institu- tions surveyed evaluated the incidence ... severe injury as defined by an Injury Severity Score greater than 16 and single-system injuries (e.g. head and spinal cord injuries) of the central nervous system [5]. However, the use of r...

Ngày tải lên: 12/08/2014, 19:21

... decreased in abundance in a ddm1 - mutant background. Interdependent mechanisms involving chromatin remodeling, DNA methy- lation, histone methylation and siRNAs therefore maintain mobile elements in ... RNA-directed DNA methylation that is triggered by a number of loci involving inverted repeats, but DRM proteins have only a partial role in the active maintenance of asymmetric and CN...

Ngày tải lên: 14/08/2014, 14:21

... all sorts. Its interesting and diverse biology and ease of breeding in a variety of con- ditions has made Drosophila a favorite laboratory model organism. As the leading player in its genus, Drosophila melanogaster ... 2000, 287:2185-2195. 2. Dobzhansky T: Genetics and the Origin of Species. New York: Colum- bia University Press; 1937. 3. Lewontin RC, Hubby JL: A molecular approach to the...

Ngày tải lên: 14/08/2014, 14:21

... of dinoflagellates is enriched in genes encoding hydrophobic proteins [14]. These initial observations instigated the ‘hydrophobicity hypothesis’, which was first proposed by von Heijne in 1986 ... less than wild-type plants) [43], possibly as a result of ineffective or inefficient assembly of the cytosolically synthe- sized protein. This example indicates that assembly may define an orga...

Ngày tải lên: 14/08/2014, 14:21

... steadily in the past few decades, as the binding sites for regulatory proteins have become better characterized and algorithms for finding cognate sites have improved. Yet the ability to make inferences ... terminator/anti- terminator mRNA structures in other systems. Yet Tina Henkin (Ohio State University, Columbus, USA) has recently proposed that many Gram-positive bacteria regulate gen...

Ngày tải lên: 14/08/2014, 14:21

... The system employed 274 physicians (6 years of training) and 837 nurses (2 years of training) and feldshers (3 years of training, akin to a physician’s assistant) The NK health system retains ... remaining in NK woul d likely increase the uptake of trainings the p artici- pants deem valuable to the community. • In sum, five key principles for planning training strategies were applied Trai...

Ngày tải lên: 13/08/2014, 15:21

... dataset. This analysis suggests that 1 in 20 proteins are likely to contain tandem repeat copy-number polymorphisms within coding regions; these were prevalent among protein-bind-ing proteins.</p> Abstract Background: ... proteins investigated carrying detectable polymorphisms in the copy-number of protein-coding tandem repeats. We found no evidence that tandem repeat copy-numbe...

Ngày tải lên: 14/08/2014, 14:21

... narrow range. Accordingly, proteins containing domains that consist of significantly larger or smaller numbers of residues than closely related members of the same family may be suspected to be ... 1100:: 201 Review IIddeennttiiffyyiinngg pprrootteeiinn ccooddiinngg ggeenneess iinn ggeennoommiicc sseeqquueenncceess Jennifer Harrow*, Alinda Nagy † , Alexandre Reymond ‡ , Tyler Alioto § , La...

Ngày tải lên: 14/08/2014, 21:20