Báo cáo y học: "Towards the visualization of genome activity at nanoscale dimensions" potx
Báo cáo y học: "Towards the visualization of genome activity at nanoscale dimensions" potx
... achieved by inhibiting the fluorescence of molecules at
the outer region of a scanning excitation spot in a saturated
manner. With the use of carefully chosen dyes and focal
intensity conditions, ... calibration (that is, by spectral precision distance
microscopy (SPDM) and spatially modulated illumination
(SMI)). For co-localization studies in fixed cells, the distance
betwee...
Báo cáo y học: "Predicting the future of anti-tumor necrosis factor therapy" potx
... a primary
phase directly after the start of treatment and a secondary
phase that develops in initial responders during the course of
therapy. The latter is explained by the formation of anti-drug
antibodies ... that TNF-blocking therapy is effective for only approxi-
mately two thirds of patients, reflecting that there are ‘responders’
as well as ‘nonresponders’. Given the d...
Báo cáo y học: "Measuring the accuracy of genome-size multiple alignments" pot
... GTTGCtATGC-AAAAATATTATGGCTTTACTAAAATTTATACAAG CATGTCAA TTAACAC
Tenrec
GTTGCCATaC-AAAAATATTATGGCTTTACTAAAATTTATACAAG CATGTCAA TTAACAC
Opossum
GTTGCCATGC-AAAAATATTATGGCTTTACTAAAATTTATACAAG CATaTCAA ... GTTGCCATGC-AAAAATATTATGGCTTTACTAAAATTTATACAAG CATGTCAA TTAACAC
Rhesus
GTTGCCATGC-AAAAATATTATGtCTTTACTAAAATTTATACAAG CATGTCAA TTAACAC
Mouse
GTTGCCATGC-AAAAATATTATGGCTTTACTAAAATTTATACAAG CgTGTC...
Báo cáo y học: "Making the most of high-throughput protein-interaction data" potx
... clearly on
a journey analogous to the one that started 15 years ago
and ended with the first draft of the human genome. At
last year’s meeting, Richard Gibbs, one of the fathers of
the human genome ... warehouses of protein-
interaction data. It was good news indeed to hear that they
have agreed to cooperate within the International Molecular
Exchange (IMEX) consortiu...
Báo cáo y học: " Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1" pot
... multimerization on membranes
thereby modulating HIV-1 assembly. The formation of the HIV-1 RNP is dynamic and likely central to the fate of the
vRNA during the late phase of the HIV-1 replication cycle.
Results: ... expectation because
packaging into virions of the virus-specific RNA harbor-
ing this deletion was less than 2% of that of the wild-type
virus [50]....
Báo cáo y học: "Towards the uniform distribution of null P values on Affymetrix microarrays" doc
... can
examine the effect of cross-hybridization by taking advantage
of the experimental design of the Latin Square dataset. For
each of the 91 possible pairs of experiments in the Latin
Fitting data to ... On the other
hand,
θ
2
is an estimate of the standard error of every gene on
the array. We take as our
θ
2
simply the average of all σ
2
values.
That is...
Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... explanations for the failure of this study to
demonstrate a benefit for MET. The mostly likely
explanation was that the study was underpowered. The
initial power and sample size calculations ... While we
cannot definitively say that MET systems improve
outcomes, it seems self-evident that the goal of identifying
and treating patients early in the course of their illnes...
Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... efficiency of the
enzyme, the cold adaptation of the enzyme could not be
attributed to the presence of the Gly cluster in this element.
The present study supports the idea that the Gly cluster,
in ... compared to the wild-type
enzyme). Interestingly, the activity of the mutant at elevated
temperatures (20–25 °C) exceeded that of the wild-type
protein. Furt...
Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... col-
lapse of the tertiary structure of RNase A coinciding with
the loss of its enzymatic activity. In contrast to the dena-
turation by guanidine hydrochloride, urea or temperature,
the breakdown of the ... indicate a detectable
increase in the content of secondary structure only after the
disruption of the native tertiary structure of RNase A
(Figs 2–4). Inter...
Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx
... and the wild-type FNRs.
Thus, the k
cat
and K
Fd
m
steady-state parameters and the k
obs
for the fast ET processes with Fd suggest that in the case of
the E139Q mutant formation of the alternative ... FNR
mutants at E139 were determined for two reactions
catalysed in vitro by FNR by fitting the experimental data
to the Michaelis–Menten equation.
Diaphorase activity. T...
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