Báo cáo y học: "A novel approach to identifying regulatory motifs in distantly related genomes" pps

... Article R113 Method A novel approach to identifying regulatory motifs in distantly related genomes Ruth Van Hellemont * , Pieter Monsieurs * , Gert Thijs * , Bart De Moor * , Yves Van de Peer † ... successful in the identification of regulatory motifs, phylogenetic footprinting methods still show some shortcomings. To assess these difficulties, most apparent when ap...

Ngày tải lên: 14/08/2014, 16:20

... other factors may explain the failure of MMP inhibitors in clinical trials. For instance, some members of the MMP family were recently shown to exert an anti-inflammatory activity in some physiolog- ical ... stimulated by inflammatory cytokines [21,22]. To assess whether inflammation does cor- relate with the proteolytic activity in arthritic joints, we first compared the NPA with t...

Ngày tải lên: 09/08/2014, 08:22

... later complaining that the pain in his left calf area persisted and could be further aggravated by tiptoeing and weight bearing maneuvers. Again, US examination in the prone position did n ot reveal any ... sonographic findings. However, he still complained of persistent pain in his left calf area. A different ultrasound examination approach was then performed with the patient lying...

Ngày tải lên: 11/08/2014, 17:21

... tensor: K KKK KKK KKK xx zz xy xz yx yy yz zx zy = ⎡ ⎣ ⎢ ⎢ ⎢ ⎤ ⎦ ⎥ ⎥ ⎥ . Considering the mass flux of fluid into an REV, and by further d efining R* Δx y z to be the volumetric inflow rate (with R* > 0 referring to ... soaking in excess water. However , swelli ng does not hint to any permeability property, but simply means that corneocytes contain pro- teins that can bind water mol...

Ngày tải lên: 13/08/2014, 16:20

... used to obtain DNA-microarray data of improved quality. A novel scheme to assess factors involved in the reproducibility of DNA-microarray data Running title: a novel scheme to assess ... due to hybridization and sampling. Some factors are confounded Due to the fact that in our DNA-microarray laboratory validation experiments are only performed when necessary...

Ngày tải lên: 14/08/2014, 14:21

... Symptoms in HCV infection do not appear to be linked to disease activity; neither do appear to be correlated with serum aminotransferase levels or liver histological findings [15,16]. In ... A phase II study indicated a lower rate of anemia induced by viramidine than ribavirin. However, its efficacy remains to be determined by ongoing clinical trials. Several types of HCV-s...

Ngày tải lên: 02/11/2012, 09:51

... hepatic inflammation carry a significantly higher risk of disease progression. Histological staging of HBV disease is clinically very valuable in assessing degree of fibrosis and predicting disease ... liver biopsy may not be necessary. As it will be discussed below, histological assessment is very valuable in determining HBV treatment in patients with persistently normal transaminas...

Ngày tải lên: 03/11/2012, 09:41

... basic indexing methods by presenting a novel approach using a con- cept vector space model for extracting and weighting indexes. Our experiment for semantic indexing sup- ports the validity of ... index term extraction based on the concept vector space, which will be ex- plained in the next section. 3.2 Lexical Chains and Concept Vector Space Model Lexical chains are employed to link...

Ngày tải lên: 23/03/2014, 19:20

... behavior can only yield partial insight into circadian entrainment. It is presently impossible to directly measure SCN activity in vivo, and thus it is impos- sible to measure entrainment in the purest ... they returned the device for data analyses. In addition to wear- ing the Daysimeter, participating nurses provided urine samples, obtained every four hours, for subsequent mela-...

Ngày tải lên: 10/08/2014, 09:20

... mixture of baits. For example, intravenously administered phage display library has been successfully used for in vivo bio-panning in certain animal model systems to identify tissue-specific peptide ... synthetic biotinylated TMG peptide (Fig. 1C, TMG). Conversely, phages displaying the TMG peptide bind to a synthetic biotinylated DSP peptide (Fig. 1C, DSP). In the absence of biotin...

Ngày tải lên: 11/08/2014, 10:23